DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rut and Phlpp1

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_598582.3	Gene:	Phlpp1 / 98432	MGIID:	2138327	Length:	1687	Species:	Mus musculus

Alignment Length:	1460	Identity:	247/1460 - (16%)
Similarity:	432/1460 - (29%)	Gaps:	563/1460 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   508 PSAASALGGGVSVGGGGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPP----- 567
            |.|.:.:.....:.|.|.|....:|      |.:.:|.:|..|     |:::.:..|.||
Mouse   377 PKAPTGVDSTGVIAGEGPGDDKAMA------AAAPDVPLSTSG-----RIRETVQKTSPPSLYVQ 430

  Fly   568 -HG----------------------MGYGSVVG-SGGGVDSGISGGGGCVSGGIAGGGGVQVTVG 608
             ||                      :|:|.:.. ...|:||.|    ||:....||
Mouse   431 LHGETTRRLEADEKPLQIQNDYLFQLGFGELWRVQEEGMDSEI----GCLIRFYAG--------- 482

  Fly   609 TNPNSTASTISRIH---RHNHKNNKSQ--------------------SKVAD------------- 637
             .|:||.|: .||.   .:|.:..|.|                    |.|.|
Mouse   483 -KPHSTGSS-ERIQLSGMYNVRKGKMQLPVNRWTRRQVILCGTCLIVSSVKDSVSGKMHVLPLIG 545

  Fly   638 -KFKRPFRKRHSVA-AHHQPTN------------------RVNRFLSQAINARSVDCDKSEHV-- 680
             |.:...:.:|.:| :...|.:                  :|::..||.|::..:.|...||:
Mouse   546 GKVEEVKKHQHCLAFSSSGPQSQTYYICFDTFTEYLRWLRQVSKVASQRISSVDLSCCSLEHLPA 610

  Fly   681 ------DRLTLRFRQS---------------DMER-EYHKDFDL------GFTTAMGCSL----- 712
                  |...|..:|:               :::| ...|..:|      .|.:|: ||:
Mouse   611 NLFYSQDLTHLNLKQNFLRQTPTLPAARGLGELQRFTKLKSLNLSNNHLGAFPSAV-CSIPTLAE 674

  Fly   713 ----------------------LLLILGAALQVTALP------RTLILLLLFLFAFIWVSAILML 749
                                  ..|:.|..||  :||      ..|..|.|....|..:..:|..
Mouse   675 LNVSCNALREVPAAVGDMQNLQTFLLDGNFLQ--SLPAELESMHQLSYLGLSFNEFTDIPEVLEK 737

  Fly   750 LLAVRLKWIIWDISESFSLR------------MAITIFTVILIYSVGQVNVFTCVS--DHPCSGN 800
            |.||....:..:..|:..|:            :.:.|...::...|..|...|.:.  |:.....
Mouse   738 LTAVDKLCMAGNCVETLRLQALRRMPHIKHVDLRLNILRKLMADEVDFVQHVTQLDLRDNKLGDL 802

  Fly   801 GTTSFQNDSHRKCSLPQYVSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQNIF- 864
            ....|.|.....|...|.|:|:....||..        ::.|...|....:|.:...||:.::.
Mouse   803 DAMIFNNIEVLHCERNQLVTLNVCGYFLKA--------LYASSNELAQLDVYPVPNYLSYMDVSR 859

  Fly   865 ECYDNRVNASIPLHLISLARIAIFMIAILVHGRLVEGTARL-------------DFLWQLQASQE 916
            .|.:     |:|..:....::.:..|.   |.::.|..|||             :.|.:|....|
Mouse   860 NCLE-----SVPEWVCESRKLEVLDIG---HNQICELPARLFCNSSLRKLLAGHNRLARLPERLE 916

  Fly   917 KKEMDVLQESNKRILH---NLLPAHVAAHFLDAQ------------------------FRNN--- 951
            :..::||...:.:|..   |||....:..||:|.                        ..||
Mouse   917 RTSVEVLDVQHNQITELPPNLLMKADSLRFLNASANKLETLPPATLSEETSSILQELYLTNNCLT 981

  Fly   952 ------------MELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGLECL-------RLLNEIIA 997
                        :::.|.:|.::....||.....|...|:|.|...|:.:       |.::.:||
Mouse   982 DKCVPLLTGHPRLKILHMAYNRLQSFPASKMAKLEELEEIDISGNKLKAIPTTIMNCRRMHTVIA 1046

  Fly   998 D------FDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEY---KIQPND----PNSVRRHMT-AL 1048
            .      |.|:::....:.:|    :....::.:.| ||.   |:|..|    |.....|.: .|
Mouse  1047 HSNCIEVFPEVMQLPEVKCVD----LSCNELSEITL-PENLPPKLQELDLTGNPRLALDHKSLEL 1106

  Fly  1049 IEYVKAMR---------HSLQEINSHSY-----------------NNF----------------- 1070
            :..::..:         .....:.||.|                 |||
Mouse  1107 LNNIRCFKIDQPSAGDASGAPAVWSHGYTEASGVKNKLCVAALSVNNFRDNREALYGVFDGDRNV 1171

  Fly  1071 ----MLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDST------GVPGYSQVTQEVVDSL 1125
                :|:  ..:..::|..:...|.:.:...||..|..|...|      |......:..:.||
Mouse  1172 EVPYLLQ--CTMSDILAEELQKTKNEEEYMVNTFIVMQRKLGTAGQKLGGAAVLCHIKPDPVD-- 1232

  Fly  1126 VGSHFEF------RCRGTIKVKGKGDMV--TYFL-CDSGNKSL---------NGEVRNAMSLPQS 1172
            :|..|..      :|:..:...||...:  :|.: |:...|.:         :|:|.   .:.:|
Mouse  1233 LGGSFTLTSANVGKCQTVLCRNGKPLSLSRSYIMSCEEERKRIKQHKAIITEDGKVN---GVTES 1294

  Fly  1173 LHAPDY-YMKVSQFPENRVNTDTYSKKENGHLYAGNGV----------------------EEQQL 1214
            .....| ::..|..|...|.:...:.::...:....|:                      .::..
Mouse  1295 TRILGYTFLHPSVVPRPHVQSVLLTPQDEFFILGSKGLWDSLSIDEAVEAVRNVPDALAAAKKLC 1359

  Fly  1215 LLQHQHKQHD-------------------------PLPLPAP---PPPVHHHLHQQQQQRLNSKL 1251
            .|...:..||                         .:|.|:|   ||.|            |..:
Mouse  1360 TLAQSYGCHDSISAVVVQLSVTEDSFCCCELSAGGSMPPPSPGIFPPSV------------NMVI 1412

  Fly  1252 QKQPIFMANG-GLPNIRENGNGHNGEHQQQQQQQQQHQQQQQQQQQHGGFMVATTTPPAAV---A 1312
            :.:|   ::| |:|:   :.:|...|...:....:...:...         .|:..||:.|   :
Mouse  1413 KDRP---SDGLGVPS---SSSGMASEISSELSTSEMSSEVGS---------TASDEPPSGVLNES 1462

  Fly  1313 VPLQPQHHQLQFQHPHQHPLPSAVSVPVQHQILLHHQLQLQ-------------------HQPVP 1358
            .|..|...:...                 |.:.|.:..|.|                   .:|:.
Mouse  1463 SPAYPNEQRCML-----------------HPVCLSNSFQRQLSSATFSSAFSDNGLDSDDEEPIE 1510

  Fly  1359 SVMLR------EFNI-IENPTSGGRHQQMEQLPPH--------HGSLDLSGMGMGVGAGVLGSDC 1408
            .|...      |.:| ........|.|.:.|:|..        ..:.|.||:........:|:
Mouse  1511 GVFSNGSRVEVEVDIHCSRAKEKERQQHLLQVPAEASDEGIVISANEDESGLSKKADFSAVGT-- 1573

  Fly  1409 FMMPRRDRERTYVPPLNQHGHHPPHHLHSNLNLNQSQHPPSFTSLGYGQCRESEPLLHASSVAPV 1473
              :.||....:..|....|.                                   ::..::.||:
Mouse  1574 --IGRRRANGSVAPQERSHN-----------------------------------VIEVAADAPL 1601

  Fly  1474 AK-----IMPMQHAPKYE---PPRYTSPHTMLSQQHQQQQQQQHQHQQPQSQSAQDQQTHPAQDP 1530
            .|     ..|.|..|..:   ||........:.:.||:|||||.|.|.|.          |.|.|
Mouse  1602 RKPGGYFAAPAQPDPDDQFIIPPELEEEVKEIMKHHQEQQQQQQQQQLPP----------PPQPP 1656

  Fly  1531 HPLQRQYAMYSQQPQLPPKPVLRTYMKPLP 1560
            .| |.|     .|||..|:|.....|..||
Mouse  1657 QP-QPQ-----PQPQPQPQPQRHFQMDHLP 1680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831
		CYCc	230..425	CDD:214485
		Guanylate_cyc	266..438	CDD:278633
		DUF1053	624..696	CDD:283888	21/148 (14%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	28/165 (17%)
		CYCc	924..1134	CDD:214485	52/331 (16%)
		Guanylate_cyc	954..1151	CDD:278633	47/278 (17%)
Phlpp1	NP_598582.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..96
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..406		7/34 (21%)
		PH_PHLPP-like	491..587	CDD:270131	12/95 (13%)
		PH	511..592	CDD:278594	8/80 (10%)
		LRR_RI	581..885	CDD:238064	56/322 (17%)
		LRR_8	594..659	CDD:290566	10/64 (16%)
		LRR 1	594..615		4/20 (20%)
		leucine-rich repeat	597..617	CDD:275380	3/19 (16%)
		LRR 2	617..638		3/20 (15%)
		leucine-rich repeat	618..648	CDD:275380	3/29 (10%)
		LRR_8	647..726	CDD:290566	15/81 (19%)
		LRR 3	648..669		5/21 (24%)
		LRR 4	671..692		0/20 (0%)
		leucine-rich repeat	672..694	CDD:275380	0/21 (0%)
		LRR 5	694..715		6/22 (27%)
		leucine-rich repeat	695..717	CDD:275380	6/23 (26%)
		LRR 6	717..739		5/21 (24%)
		leucine-rich repeat	718..740	CDD:275380	6/21 (29%)
		LRR 7	740..760		4/19 (21%)
		leucine-rich repeat	741..764	CDD:275380	3/22 (14%)
		LRR 8	764..785		2/20 (10%)
		LRR_RI	768..1030	CDD:238064	50/277 (18%)
		leucine-rich repeat	768..788	CDD:275380	3/19 (16%)
		LRR 9	788..809		3/20 (15%)
		leucine-rich repeat	789..809	CDD:275380	3/19 (16%)
		leucine-rich repeat	810..851	CDD:275380	9/48 (19%)
		LRR 10	829..850		5/28 (18%)
		LRR 11	851..872		5/25 (20%)
		leucine-rich repeat	852..874	CDD:275380	5/26 (19%)
		LRR 12	874..895		6/23 (26%)
		leucine-rich repeat	875..897	CDD:275380	6/24 (25%)
		LRR_8	896..954	CDD:290566	12/57 (21%)
		LRR 13	897..918		3/20 (15%)
		leucine-rich repeat	898..919	CDD:275380	3/20 (15%)
		LRR 14	919..940		6/20 (30%)
		leucine-rich repeat	920..943	CDD:275380	6/22 (27%)
		LRR 15	943..964		3/20 (15%)
		leucine-rich repeat	944..967	CDD:275380	3/22 (14%)
		LRR 16	969..989		2/19 (11%)
		LRR_8	970..1028	CDD:290566	10/57 (18%)
		leucine-rich repeat	970..993	CDD:275380	2/22 (9%)
		LRR 17	993..1014		4/20 (20%)
		leucine-rich repeat	994..1017	CDD:275380	4/22 (18%)
		LRR 18	1017..1038		4/20 (20%)
		LRR 19	1040..1061		4/20 (20%)
		LRR 20	1062..1083		4/25 (16%)
		leucine-rich repeat	1063..1085	CDD:275380	4/26 (15%)
		LRR 21	1085..1106		5/20 (25%)
		PP2Cc	1124..1376	CDD:214625	36/258 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1414..1465		10/65 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1604..1687		29/93 (31%)
		PDZ-binding	1685..1687
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900