DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rut and Adcy7

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_445848.1	Gene:	Adcy7 / 84420	RGDID:	619966	Length:	1100	Species:	Rattus norvegicus

Alignment Length:	1234	Identity:	414/1234 - (33%)
Similarity:	593/1234 - (48%)	Gaps:	259/1234 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ENDELECLYQRYTLKLQRFSVLGVVALVFV-LCGVMAALSLTFN------NAATFHNIFNAIVCG 76
            |..:...||::|.|..|...:|.::.||.| .|  :|.:|:.|:      :.|.....|  .:..
  Rat    14 EGPKQAALYEKYRLTSQHGPLLLLLLLVAVATC--IALVSIVFSHEDLRRHQAVLGTAF--FMLT 74

  Fly    77 LFAVVLVLLQCSVIKDHHLPTLCYGILLFTASICVVSMPTLGSVFPVDTKEVMAEGVWQ----IV 137
            ||..:.||:....:....|..|.   ||..|.:.:     ||||...|:.|..|. .|:    .:
  Rat    75 LFVALYVLVYVECLAQRWLRVLA---LLTWACLMI-----LGSVLMWDSLENEAY-AWEQVPFFL 130

  Fly   138 FVVFLAYAMMPLQIWEAVAFGIALPSVHISL--TVYKIFTDALRYLEYN-QLIANIVIFIGVNVA 199
            |:||:.|.::||....|:|.|:|....|:.:  .|.:.|..::...:.. ||:||.||.:|.|..
  Rat   131 FIVFVVYVLLPLSTRAAIAVGVASTISHLLVFGAVTRAFKTSMSSTQLGLQLLANAVILLGGNFT 195

  Fly   200 GLVVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDILSPVA---- 260
            |......::.|.|..|:.|..||..|.:::.|..:.|.|||||||.|::|.||..|:..:.
  Rat   196 GAFHKHQLQDASRDLFIYTVKCIQIRRKLRVEKRQQENLLLSVLPAHISMGMKLAIIERLKEGGD 260

  Fly   261 ------GQFHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRI 319
                  ..||.:|:::|:|||||:|||||||.|:|.||.:|||.:||||||:|||:|..|.|:||
  Rat   261 RHYTPDNNFHSLYVKRHQNVSILYADIVGFTRLASDCSPKELVVVLNELFGKFDQIAKANECMRI 325

  Fly   320 KILGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLR 384
            ||||||||||||||.....||:..|:||||:.:||..|.|||.|.::||||||:|.|||||:|||
  Rat   326 KILGDCYYCVSGLPVSLPTHARNCVKMGLDICEAIKQVREATGVDISMRVGIHSGNVLCGVIGLR 390

  Fly   385 KWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFFIV 449
            |||:||||:||:|||.||:.|.|||||:|.|||:.|...||||.|||::|..||::..:.|:.::
  Rat   391 KWQYDVWSHDVSLANRMEAAGVPGRVHITEATLNHLDKAYEVEDGHGEQRDPYLKEMNIRTYLVI 455

  Fly   450 PPPHRRKPLMLNTLGVRSAIGSRRKLSFRNVSNVVMQLLHTIKFSEPVPFSNIATGSFPSAASAL 514
            .|..::.||..:.|                              |:|
  Rat   456 DPRSQQPPLPSHHL------------------------------SKP------------------ 472

  Fly   515 GGGVSVGGGGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYGSVVGSG 579
                                      .|:..:..:.|.:|.|..:
  Rat   473 --------------------------KGDATLKMRASVRVTRYLE-------------------- 491

  Fly   580 GGVDSGISGGGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRH-NHKNNKSQSKVADKFKR-- 641
                          |.|.|                     |...| ||:.:.|.|::.....|
  Rat   492 --------------SWGAA---------------------RPFAHLNHRESVSSSEIPIPNGRRQ 521

  Fly   642 ---PFRKRHSVAAHHQPTNRV-----NRFLS--QAINARSVDCDKSEHVDRLTLRFRQSDMEREY 696
               |.|:..:......|..|:     :..||  :.:::....|.||:........|.:...||||
  Rat   522 KAIPLRRHRAPDRSASPKGRLEDDCDDEMLSAIEGLSSTRPCCSKSDDFHTFGPIFLEKGFEREY 586

  Fly   697 --------HKDFDLGFTTAMGCSLLLLILGAALQVTALPRTLILLLLFLFAFIWVSAILMLLLAV 753
                    ..||        .|:.|:.:....:.:..:||...|.|.|......:..:|....|.
  Rat   587 RLVPIPRARYDF--------ACASLVFVCILLVHLLVMPRMATLGLSFGLVACLLGLVLSFCFAT 643

  Fly   754 RL------KWIIWDISESFS----LRMAITIFTVILIYSVGQVNV---FTCVSDHPCSGNGTTS- 804
            ..      :..:..||||..    ||:::.:.||..:.:|..:|:   |....:.|  |:..||
  Rat   644 EFSRCLPARSTLQAISESVETQPLLRLSLVVVTVGSLLTVAIINMPLTFNPGPEQP--GDNETSP 706

  Fly   805 --FQNDSHRKCSLPQYVSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQNIFECY 867
              .:|.....|.|..|.:.|....|::.|||||:.:..|::|:......|.|...||     .|:
  Rat   707 LAARNRVGTPCELLPYYTCSCVLGFIACSVFLRMSLELKAMLLTVALVAYLLLFNLS-----PCW 766

  Fly   868 DNRVNA-----------------SIPLHLISLAR----------------------IAIFMIAIL 893
            ....|:                 |:..|.::|..                      :.:|...::
  Rat   767 QVSGNSTETNSTHRTRRLLSAEQSMNSHTLALGAQMTAPSPSSCLERDLKTMINFYLVLFYATLI 831

  Fly   894 VHGRLVEGTARLDFLWQLQASQEKKEMDVLQESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQS 958
            :..|.::...|||.||:.:..:|.:|.:.::..|:.:|.|:|||||||||:..:...  :.||||
  Rat   832 LLSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKAAE--DWYHQS 894

  Fly   959 YAKVGVIFASVPNFNEFYTEMDGSDQGLECLRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMA 1023
            |..|.|:|||||:|..||||.|.:.:|||||||||||||||||||.:.:|.|::||||:||||||
  Rat   895 YDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMA 959

  Fly  1024 VVGLIPEYKIQPNDPNSVRRHMTALIEYVKAMRHSLQEINSHSYNNFMLRVGINIGPVVAGVIGA 1088
            ..||......:..|......|:..|:|:..|:...|..||.||:|:|.||||||.|||:||||||
  Rat   960 AAGLSVPSGHENQDLERKHVHIGVLVEFSMALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGA 1024

  Fly  1089 RKPQYDIWGNTVNVASRMDSTGVPGYSQVTQEVVDSLVGSHFEFRCRGTIKVKGKGDMVTYFLC 1152
            ||||||||||||||||||:|||..|..|||:|....|.|..:...|||.|.|||||::.|||:|
  Rat  1025 RKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVC 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	75/249 (30%)
		CYCc	230..425	CDD:214485	119/204 (58%)
		Guanylate_cyc	266..438	CDD:278633	111/171 (65%)
		DUF1053	624..696	CDD:283888	18/84 (21%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	40/205 (20%)
		CYCc	924..1134	CDD:214485	118/209 (56%)
		Guanylate_cyc	954..1151	CDD:278633	117/196 (60%)
Adcy7	NP_445848.1	AC_N	<21..251	CDD:318454	74/242 (31%)
		Guanylate_cyc	272..422	CDD:306677	99/149 (66%)
		DUF1053	487..593	CDD:399378	25/160 (16%)
		Guanylate_cyc	891..1087	CDD:306677	117/195 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.710