DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rut and si:dkey-37g12.1

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	XP_021333677.1	Gene:	si:dkey-37g12.1 / 796669	ZFINID:	ZDB-GENE-090312-145	Length:	882	Species:	Danio rerio

Alignment Length:	449	Identity:	107/449 - (23%)
Similarity:	185/449 - (41%)	Gaps:	129/449 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 LQCSVIKD----HHLPTLCYGILLFTASICVVSMP--------TLGSVFPVDTKEVMAEGVW--- 134
            |...::|.    ||.|...:|.|  ::|.|||...        .|.||..:||::......|
Zfish   463 LMLDIVKGMDYLHHSPLQYHGHL--SSSSCVVDSRFVLKVTDFGLNSVRRLDTEQSPGSDPWTAL 525

  Fly   135 --------------------QIVFVVFLAYAMM--------------PLQIWEAVAFGIALPSVH 165
                                .:.....:|..::              |.:|.|.|..|...||
Zfish   526 LWRAPELLRQSIPANGTQKGDVYSFAIIAQEVVYRRGPFYIPNSHFSPREIVERVRAGGCSPS-- 588

  Fly   166 ISLTVYKIFTDALRYLEYNQLIANIVIFIGVNVAGLVVNIMMER-AQRRTFLDTRNCI------- 222
                  :.:.|....:|              .:..|||:...|. |:|..|...|..|
Zfish   589 ------RPYIDRAECVE--------------ELESLVVSCWRETPAERPDFSYIRTAIKKNSPHG 633

  Fly   223 ---------ASRL----------------EIQDENEKLERLLLSVLPQHVAMQMKNDILSPVAGQ 262
                     .||:                |:|:|.::.|.||..:||:.||.|:       :||:
Zfish   634 VSENILDDLLSRMEQYACNLEEIVSERTAELQEEKKRAEGLLTQMLPRSVASQL-------IAGK 691

  Fly   263 FHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYY 327
              .:..:.::.|:|.|:||.|||.:|:..:..::|.:||:|:..||.:...::..:::.:||.|.
Zfish   692 --TVRAETYDCVTIYFSDIEGFTAMSASLTPMQVVNVLNDLYTYFDNIIDYHNVYKVETIGDAYM 754

  Fly   328 CVSGLP-EPRKDHAKCAVEMGLDMIDAIATV--VEATDVILNMRVGIHTGRVLCGVLGLRKWQFD 389
            .||||| ....||||....|.|.::..:.:.  ....:..|.:|:|:|:|..:.||:||:..::.
Zfish   755 VVSGLPIRNGDDHAKEIARMSLAIVQGLRSFHSPHVPEQQLRVRIGVHSGPCVAGVVGLKMPRYC 819

  Fly   390 VWSNDVTLANHMESGGEPGRVHV---TRATLDS-------LSGEYEVEAGHGDERSSYL 438
            ::.:.|..|:.|||.|.|.::||   |::.||:       |.|:..:: |.|..|:.:|
Zfish   820 LFGDTVNTASRMESYGLPLKIHVSSSTKSLLDTFRNFRCELRGDIHIK-GKGWVRTFWL 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	49/251 (20%)
		CYCc	230..425	CDD:214485	63/207 (30%)
		Guanylate_cyc	266..438	CDD:278633	55/184 (30%)
		DUF1053	624..696	CDD:283888
		SLC5-6-like_sbd	<742..>893	CDD:294310
		CYCc	924..1134	CDD:214485
		Guanylate_cyc	954..1151	CDD:278633
si:dkey-37g12.1	XP_021333677.1	Periplasmic_Binding_Protein_Type_1	<59..258	CDD:324556
		PKc_like	355..628	CDD:328722	36/188 (19%)
		HNOBA	<641..687	CDD:311573	12/45 (27%)
		CYCc	666..850	CDD:214485	59/192 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900