DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rut and Gucy1a2

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_076446.1	Gene:	Gucy1a2 / 66012	RGDID:	621655	Length:	730	Species:	Rattus norvegicus

Alignment Length:	433	Identity:	111/433 - (25%)
Similarity:	185/433 - (42%)	Gaps:	105/433 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 TFNNAATFHNIF--NAIVCGLFAVVLVLLQCSVIKDHHLPTLCYGILLFTASICVVSMPTLGSVF 121
            ||.....||.:|  |.:|..|...:...|:|    |:|      .:|.|.....:|| |.:.:.|
  Rat   320 TFCRTFPFHLMFDPNMVVLQLGEGLRKQLRC----DNH------KVLKFEDCFEIVS-PKVNATF 373

  Fly   122 P--------------------VDTKEVMAEGVWQIVFV------VFLAYAMMPLQIWEAVAFGIA 160
            .                    .|.::.:.|...|::.|      :||....:. ::.|.:..|:.
  Rat   374 DRVLLRLSTPFVIRTKPEASGTDNEDKVMEIKGQMIHVPESNAILFLGSPCVD-KLDELIGRGLH 437

  Fly   161 LPSVHISLTVYKIFTDALRYLEYNQLIANIVIFIGVNVAGLVVNIMMERAQRRTFLDTR-NCIAS 224
            |..:.|.        ||.|          .||.:|            |:|:.:..|..| :.:.:
  Rat   438 LSDIPIH--------DATR----------DVILVG------------EQAKAQDGLKKRMDKLKA 472

  Fly   225 RLE-----IQDENEKLERLLLSVLPQHVAMQMKNDILSPVAGQFHRIYIQKHENVSILFADIVGF 284
            .||     :::|.:|...||.|:.|..||.|:         .|..::..:|.::|::||:|||||
  Rat   473 TLEKTHQALEEEKKKTVDLLYSIFPGDVAQQL---------WQRQQVQARKFDDVTMLFSDIVGF 528

  Fly   285 TVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYYCVSGLPEPRKDHAKCAVEMGLD 349
            |.:.:||:..:::.:||||:.|||.........:::.:||.|...|||......|||....|.|.
  Rat   529 TAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVASGLHRKSLCHAKPIALMALK 593

  Fly   350 MIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDVTLANHMESGGEPGRVHVTR 414
            |::....|:......:.||:|||:|.||.||:|:|..::.::.|:||||:..|||..|.|::::.
  Rat   594 MMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINISP 658

  Fly   415 ATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFFIVPPPHRRKP 457
            .|...|..|                    |:|..:|......|
  Rat   659 TTYQLLKRE--------------------DSFTFIPRSREELP 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	49/229 (21%)
		CYCc	230..425	CDD:214485	67/194 (35%)
		Guanylate_cyc	266..438	CDD:278633	57/171 (33%)
		DUF1053	624..696	CDD:283888
		SLC5-6-like_sbd	<742..>893	CDD:294310
		CYCc	924..1134	CDD:214485
		Guanylate_cyc	954..1151	CDD:278633
Gucy1a2	NP_076446.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53
		HNOB	<157..268	CDD:285002
		HNOBA	314..501	CDD:285003	46/222 (21%)
		CYCc	483..672	CDD:214485	69/217 (32%)
		Guanylate_cyc	512..696	CDD:278633	61/190 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810