DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rut and Adcy5

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_072122.2	Gene:	Adcy5 / 64532	RGDID:	71014	Length:	1262	Species:	Rattus norvegicus

Alignment Length:	1206	Identity:	463/1206 - (38%)
Similarity:	674/1206 - (55%)	Gaps:	242/1206 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 RFENDELECLYQRYTLKLQRFSVLGVVALVFVLCGVMAALSLTFNNAATFHN-------IFNAIV 74
            :|.:|:||.|||||..:|.:.|:..::|::.::|.||.|          ||.       ::.|::
  Rat   221 KFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLA----------FHAARPPLQVVYLAVL 275

  Fly    75 CGLFAVVLVL-LQCSVIKDH--HLPTLCYGILLFTASICVVSMPTLGSVFPVDTKEVMAEGVWQI 136
            .....|:|:: :.|:....|  |:...||.::....::.||     |.:.|  .....:||:|..
  Rat   276 AAAVGVILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVV-----GLLLP--QPRSASEGIWWT 333

  Fly   137 VFVVFLAYAMMPLQIWEAVAFGIALPSVHISLTVYKIFTDALRYLEYNQLIANIVIFIGVNVAGL 201
            ||.::..|.::|:::..||..|:.|.::|::::::   |:|.......||::|::||...|:.|:
  Rat   334 VFFIYTIYTLLPVRMRAAVLSGVLLSALHLAISLH---TNAQDQFLLKQLVSNVLIFSCTNIVGV 395

  Fly   202 VVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDILSPVAG-QFHR 265
            ..:...|.:||:.|.:||.||.:||..|.||::.|||||||||:||||:||.||.:.... .||:
  Rat   396 CTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHK 460

  Fly   266 IYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYYCVS 330
            ||||||:|||||||||.|||.|:|||:|||||..|||||.|||:||.:|||||||||||||||||
  Rat   461 IYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVS 525

  Fly   331 GLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDV 395
            ||||.|.|||.|.||||:|||:||:.|.|.|.|.:|||||||:|||.||||||||||||||||||
  Rat   526 GLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDV 590

  Fly   396 TLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFFIVPPPHRRKPLML 460
            |||||||:||:.||:|:|:|||:.|:|:||||.|.|.||::||::|.::||.|:....:||.
  Rat   591 TLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKE--- 652

  Fly   461 NTLGVRSAIGSRRKLSFRNVSNVVMQLLHTIKFSEP-----VPFSNIATGSFPSAASALGGGVSV 520
                 ..|:          ::.:..|..::|..:.|     .||.|           .|||.
  Rat   653 -----EKAM----------IAKMNRQRTNSIGHNPPHWGAERPFYN-----------HLGGN--- 688

  Fly   521 GGGGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYGSVVGSGGGVDSG 585
                                    |||::..|                 ||:
  Rat   689 ------------------------QVSKEMKR-----------------MGF------------- 699

  Fly   586 ISGGGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRHNHKNNKSQSKVADKFKRPFRKRHSVA 650
                                                  .:.|:..:|...
  Rat   700 --------------------------------------EDPKDKNAQESA--------------- 711

  Fly   651 AHHQPTNRVNRFLSQAINARSVDCDKSEHVDRLTLRFRQSDMEREYHKDFDLGFTTAMGCSLLLL 715
               .|.:.|:.||.:||:|||:|..:||||.:..|.||:.|:|::|.|..|..|...:.|:.|:.
  Rat   712 ---NPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVF 773

  Fly   716 ILGAALQVTALPRTLILLLLFLFAFIWVSAILML--------LLAVRLKWIIWDISESFSLRMAI 772
            :....:|:|.:|.:|.:|..:|..|:.::.::.:        |....|:.:...|..|......:
  Rat   774 LFICFVQITIVPHSLFMLSFYLSCFLLLALVVFISVIYACVKLFPTPLQTLSRKIVRSKKNSTLV 838

  Fly   773 TIFTVILIYSVGQVNVFTCVS---------DHPCSGNGTTS-----------------FQNDSHR 811
            .:||:.|::....||:|.|.|         :|..:.|...:                 |......
  Rat   839 GVFTITLVFLSAFVNMFMCNSKNLVGCLAEEHNITVNQVNACHVMESAFNYSLGDEQGFCGSPQS 903

  Fly   812 KCSLPQYVSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQNIFECYDNRVNAS-- 874
            .|:.|:|.:.|...:.|:.||||::..|.|.:|:|.:..||.|.:|:....:|:..|..|.|:
  Rat   904 NCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAI 968

  Fly   875 ----------------IPLHLISLARIAIFMIAILVHGRLVEGTARLDFLWQLQASQEKKEMDVL 923
                            :.|.:::...|::|::|:.:|.:.||.||||||||:|||::||:||:.|
  Rat   969 DFSNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEEL 1033

  Fly   924 QESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGLEC 988
            |..|:|:|||:||..|||||| |:.|.|.|||:||...|.|:|||:.||:|||.|::.:::|:||
  Rat  1034 QAYNRRLLHNILPKDVAAHFL-ARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVEC 1097

  Fly   989 LRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEYKIQPND---PNSVRRHMTALIE 1050
            |||||||||||||::.|||||.::||||:||||||..||        ||   ..:.:.|:.||.:
  Rat  1098 LRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGL--------NDSTYDKAGKTHIKALAD 1154

  Fly  1051 YVKAMRHSLQEINSHSYNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYS 1115
            :...:...::.||.||:|||.:::|:||||||||||||||||||||||||||||||||||||...
  Rat  1155 FAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRI 1219

  Fly  1116 QVTQEVVDSLVGSHFEFRCRGTIKVKGKGDMVTYFL 1151
            |||.::...|..:.::..|||.:||||||:|:||||
  Rat  1220 QVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFL 1255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	79/247 (32%)
		CYCc	230..425	CDD:214485	143/195 (73%)
		Guanylate_cyc	266..438	CDD:278633	130/171 (76%)
		DUF1053	624..696	CDD:283888	21/71 (30%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	40/202 (20%)
		CYCc	924..1134	CDD:214485	119/212 (56%)
		Guanylate_cyc	954..1151	CDD:278633	113/199 (57%)
Adcy5	NP_072122.2	AC_N	1..459	CDD:318454	81/257 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..196
		Guanylate_cyc	461..634	CDD:306677	131/172 (76%)
		DUF1053	669..761	CDD:399378	37/215 (17%)
		Guanylate_cyc	1063..1257	CDD:306677	115/201 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.710