Protein Alignment rut and Adcy5

DIOPT Version :10

• Sequence 1: NP_511156.2
• Gene: rut / 32406
• FlyBaseID: FBgn0003301
• Length: 2248
• Species: Drosophila melanogaster
• Sequence 2: NP_072122.2
• Gene: Adcy5 / 64532
• RGDID: 71014
• Length: 1262
• Species: Rattus norvegicus
• Alignment Length: 1206
• Identity: 463/1206 - (38%)
• Similarity: 674/1206 - (55%)
• Gaps: 242/1206 - (20%)

  Fly    17 RFENDELECLYQRYTLKLQRFSVLGVVALVFVLCGVMAALSLTFNNAATFHN-------IFNAIV 74
            :|.:|:||.|||||..:|.:.|:..::|::.::|.||.|          ||.       ::.|::
  Rat   221 KFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLA----------FHAARPPLQVVYLAVL 275

  Fly    75 CGLFAVVLVL-LQCSVIKDH--HLPTLCYGILLFTASICVVSMPTLGSVFPVDTKEVMAEGVWQI 136
            .....|:|:: :.|:....|  |:...||.::....::.||     |.:.|  .....:||:|..
  Rat   276 AAAVGVILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVV-----GLLLP--QPRSASEGIWWT 333

  Fly   137 VFVVFLAYAMMPLQIWEAVAFGIALPSVHISLTVYKIFTDALRYLEYNQLIANIVIFIGVNVAGL 201
            ||.::..|.::|:::..||..|:.|.::|::::::   |:|.......||::|::||...|:.|:
  Rat   334 VFFIYTIYTLLPVRMRAAVLSGVLLSALHLAISLH---TNAQDQFLLKQLVSNVLIFSCTNIVGV 395

  Fly   202 VVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDILSPVAG-QFHR 265
            ..:...|.:||:.|.:||.||.:||..|.||::.|||||||||:||||:||.||.:.... .||:
  Rat   396 CTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHK 460

  Fly   266 IYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYYCVS 330
            ||||||:|||||||||.|||.|:|||:|||||..|||||.|||:||.:|||||||||||||||||
  Rat   461 IYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVS 525

  Fly   331 GLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDV 395
            ||||.|.|||.|.||||:|||:||:.|.|.|.|.:|||||||:|||.||||||||||||||||||
  Rat   526 GLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDV 590

  Fly   396 TLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFFIVPPPHRRKPLML 460
            |||||||:||:.||:|:|:|||:.|:|:||||.|.|.||::||::|.::||.|:....:||.
  Rat   591 TLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKE--- 652

  Fly   461 NTLGVRSAIGSRRKLSFRNVSNVVMQLLHTIKFSEP-----VPFSNIATGSFPSAASALGGGVSV 520
                 ..|:          ::.:..|..::|..:.|     .||.|           .|||.
  Rat   653 -----EKAM----------IAKMNRQRTNSIGHNPPHWGAERPFYN-----------HLGGN--- 688

  Fly   521 GGGGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYGSVVGSGGGVDSG 585
                                    |||::..|                 ||:
  Rat   689 ------------------------QVSKEMKR-----------------MGF------------- 699

  Fly   586 ISGGGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRHNHKNNKSQSKVADKFKRPFRKRHSVA 650
                                                  .:.|:..:|...
  Rat   700 --------------------------------------EDPKDKNAQESA--------------- 711

  Fly   651 AHHQPTNRVNRFLSQAINARSVDCDKSEHVDRLTLRFRQSDMEREYHKDFDLGFTTAMGCSLLLL 715
               .|.:.|:.||.:||:|||:|..:||||.:..|.||:.|:|::|.|..|..|...:.|:.|:.
  Rat   712 ---NPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVF 773

  Fly   716 ILGAALQVTALPRTLILLLLFLFAFIWVSAILML--------LLAVRLKWIIWDISESFSLRMAI 772
            :....:|:|.:|.:|.:|..:|..|:.::.::.:        |....|:.:...|..|......:
  Rat   774 LFICFVQITIVPHSLFMLSFYLSCFLLLALVVFISVIYACVKLFPTPLQTLSRKIVRSKKNSTLV 838

  Fly   773 TIFTVILIYSVGQVNVFTCVS---------DHPCSGNGTTS-----------------FQNDSHR 811
            .:||:.|::....||:|.|.|         :|..:.|...:                 |......
  Rat   839 GVFTITLVFLSAFVNMFMCNSKNLVGCLAEEHNITVNQVNACHVMESAFNYSLGDEQGFCGSPQS 903

  Fly   812 KCSLPQYVSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQNIFECYDNRVNAS-- 874
            .|:.|:|.:.|...:.|:.||||::..|.|.:|:|.:..||.|.:|:....:|:..|..|.|:
  Rat   904 NCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAI 968

  Fly   875 ----------------IPLHLISLARIAIFMIAILVHGRLVEGTARLDFLWQLQASQEKKEMDVL 923
                            :.|.:::...|::|::|:.:|.:.||.||||||||:|||::||:||:.|
  Rat   969 DFSNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEEL 1033

  Fly   924 QESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGLEC 988
            |..|:|:|||:||..|||||| |:.|.|.|||:||...|.|:|||:.||:|||.|::.:::|:||
  Rat  1034 QAYNRRLLHNILPKDVAAHFL-ARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVEC 1097

  Fly   989 LRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEYKIQPND---PNSVRRHMTALIE 1050
            |||||||||||||::.|||||.::||||:||||||..||        ||   ..:.:.|:.||.:
  Rat  1098 LRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGL--------NDSTYDKAGKTHIKALAD 1154

  Fly  1051 YVKAMRHSLQEINSHSYNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYS 1115
            :...:...::.||.||:|||.:::|:||||||||||||||||||||||||||||||||||||...
  Rat  1155 FAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRI 1219

  Fly  1116 QVTQEVVDSLVGSHFEFRCRGTIKVKGKGDMVTYFL 1151
            |||.::...|..:.::..|||.:||||||:|:||||
  Rat  1220 QVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFL 1255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:318454	79/247 (32%)
		Guanylate_cyc	266..428	CDD:425528	125/161 (78%)
		Adcy_cons_dom	624..698	CDD:461877	22/73 (30%)
		AcyC	742..1150	CDD:441717	189/462 (41%)
		Guanylate_cyc	954..1151	CDD:425528	113/199 (57%)
Adcy5	NP_072122.2	AC_N	1..459	CDD:318454	81/257 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..196
		Guanylate_cyc	461..644	CDD:425528	135/182 (74%)
		Adcy_cons_dom	669..762	CDD:461877	37/216 (17%)
		Guanylate_cyc	1063..1257	CDD:425528	115/201 (57%)