DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rut and CG34357

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster

Alignment Length:	626	Identity:	146/626 - (23%)
Similarity:	229/626 - (36%)	Gaps:	199/626 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 MMERAQRRTFLDT------------RNCIASRLEIQD-ENEKLERLLLSVLPQHVAMQMKNDI-L 256
            |:...::..|:||            ...|..|.|..| |.:|.|:||..:||..||.::|..: :
  Fly  1037 MLNHGRKVNFVDTMFQMLEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLPSSVAEKLKMGLAV 1101

  Fly   257 SPVAGQFHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKI 321
            .|          ::..:|:|.|:||||||.:::.||..::|.|||:|:..||...:..:..:::.
  Fly  1102 DP----------EEFSDVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVET 1156

  Fly   322 LGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIA--TVVEATDVILNMRVGIHTGRVLCGVLGLR 384
            :||.|..|||||....|||:....|.||::....  .|.....|.|.:|:|:|||....||:||.
  Fly  1157 IGDAYMVVSGLPVKIPDHAEQIATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLT 1221

  Fly   385 KWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDSLS--GEYEVE-------AGHGDERSSY-LR 439
            ..::.::.:.|..|:.|||.|...|:|:::.|.|.|.  |.|.:|       .|.|...:.: |.
  Fly  1222 MPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDRLDARGGYAIEPRGLIDIKGKGMMNTFWLLG 1286

  Fly   440 DHGVDTFFIVPPPHRR-----KPLMLNTLGVRS-------------------------------- 467
            ..|.|.....|||...     :.|:.|::.:::
  Fly  1287 KKGFDKPLPAPPPIGESHGLDESLIRNSITLKAQANKSRTSTNPSSSQSSSLAGESVEVKVEITP 1351

  Fly   468 ------AIGSRRKLSFRNVSNVVMQLLHTI------------------------KFSEPVPFSNI 502
                  |.|:....|:...||..    :||                        |.||..|.:.:
  Fly  1352 PTNADLASGTNLPNSYSLDSNST----NTISPNATLCPEFPGKTTPSSTSPQSRKLSELTPENLL 1412

  Fly   503 ATGSFPSAASALGGGV-----------------------------------------SVGGGGGG 526
            ...||....|:.||..                                         ||.||.||
  Fly  1413 NPNSFNRLPSSTGGSSSRLYKKIEEMMDLSSPYNHYKCLSPSESNLTQFYDGKYLYGSVAGGAGG 1477

  Fly   527 G--GGGVA-----RGSTCEANSGNVQVSEKGSRKVIRLQKIL------------HATPPPHGMGY 572
            |  |||..     .||.|...:.... |:.||.:::|.|..|            |.........|
  Fly  1478 GQAGGGACASIALSGSGCGGGASRFD-SKPGSSRLLRRQFSLDRDDQQAKGEQQHHQHSLQANTY 1541

  Fly   573 GSVVGSGGGVDSGISGGGGCVSGGIAGGGGVQVTVGTNP------NSTASTISRIHRHNHKN-NK 630
            ..:|             |||       ||||:.::...|      .|...|::|.|:.|..: .:
  Fly  1542 SGLV-------------GGC-------GGGVKSSMLDIPLLHDTTRSPKGTLTRSHKQNSASITQ 1586

  Fly   631 SQSKVADKFKRPFRKRHSVAAHHQPTNRVNRFLSQAINARS 671
            ...|:.:....|...:|    |....:.:||.....:.|:|
  Fly  1587 DLEKIEEIPLSPASSQH----HSSLDSNLNRSPPSTLEAQS 1623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	18/61 (30%)
		CYCc	230..425	CDD:214485	68/200 (34%)
		Guanylate_cyc	266..438	CDD:278633	60/183 (33%)
		DUF1053	624..696	CDD:283888	9/49 (18%)
		SLC5-6-like_sbd	<742..>893	CDD:294310
		CYCc	924..1134	CDD:214485
		Guanylate_cyc	954..1151	CDD:278633
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	1/3 (33%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	68/201 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810