Protein Alignment rut and adcy6a

DIOPT Version :10

• Sequence 1: NP_511156.2
• Gene: rut / 32406
• FlyBaseID: FBgn0003301
• Length: 2248
• Species: Drosophila melanogaster
• Sequence 2: XP_017209219.1
• Gene: adcy6a / 570652
• ZFINID: ZDB-GENE-060221-1
• Length: 1203
• Species: Danio rerio
• Alignment Length: 1219
• Identity: 461/1219 - (37%)
• Similarity: 664/1219 - (54%)
• Gaps: 247/1219 - (20%)

  Fly    11 RPLNTLRFENDELECLYQRYTLKLQRFSVLGVVALVFVLCGVMAALSLTFNNAATFHNIFN---- 71
            |...:.:|::.:||.|||||..:|.:.|:..::.::.::||||          .|||.|..
Zfish   151 RVFQSKKFQSRKLERLYQRYFFRLNQSSLTMLMGVLVIVCGVM----------LTFHCIHGPPDV 205

  Fly    72 ------AIVCGLFAVVLVLLQCSVIKDHHLPTLCY---GILLFTASICVVSMPTLGSVFPVDTKE 127
                  ::...||..::|:...:.....::..:.|   |:|:......|:.:....:
Zfish   206 VYASVLSVAMALFLALMVVCNRNGFHQDYMWMVSYLVIGVLIIVQVFGVLMVAPRSA-------- 262

  Fly   128 VMAEGVWQIVFVVFLAYAMMPLQIWEAVAFGIALPSVHISLTVYKIFTDALRYLEYNQLIANIVI 192
              :||:|..||.:::.|.::|:::..||..|..|.::|: ||.::|..|. .:| :.||.||::|
Zfish   263 --SEGIWWSVFFIYIIYTLLPVRMRAAVLSGGVLSAIHL-LTTWRINQDD-EFL-WKQLSANVLI 322

  Fly   193 FIGVNVAGLVVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDILS 257
            |:..|:.|:..:...|.:||:.|.:||..|.:||.:|.||::.|||||||||:||||:||.||.:
Zfish   323 FLCTNIIGICTHYPAEVSQRQAFQETRGYIQARLHLQRENQQQERLLLSVLPRHVAMEMKADINA 387

  Fly   258 PVAG-QFHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKI 321
            .... .||:||||||:|||||||||.|||.|:|||:|||||..|||||.|||:||.:||||||||
Zfish   388 KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLASENHCLRIKI 452

  Fly   322 LGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRKW 386
            |||||||||||||||.|||.|.||||:|||:||:.|.|.|.|.:|||||||:|||.|||||||||
Zfish   453 LGDCYYCVSGLPEPRADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKW 517

  Fly   387 QFDVWSNDVTLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFFIVPP 451
            ||||||||||||||||:||:.||:|:|:|||..|:|:||||.|.|.||::||:::.::||.:
Zfish   518 QFDVWSNDVTLANHMEAGGKAGRIHITKATLQYLNGDYEVEPGFGGERNAYLKENSIETFLV--- 579

  Fly   452 PHRRKPLMLNTLGVRSAIGSRRKLSFRNVSNVVMQLLHTIKFSEPVPFSNIATGSFPSAASALGG 516
                             :|..:|..........||...|......|| ..:...||
Zfish   580 -----------------LGCSQKRKDEKAMMAKMQRTRTNSNEALVP-RWVPDRSF--------- 617

  Fly   517 GVSVGGGGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYGSVVGSGGG 581
                                          |.....||.|..                      |
Zfish   618 ------------------------------SRTKDSKVFRQM----------------------G 630

  Fly   582 VDSGISGGGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRHNHKNNKSQSKVADKFKRPFRKR 646
            :|                             .|:|          |:|:...:..:
Zfish   631 ID-----------------------------ETSS----------KDNRGAQEALN--------- 647

  Fly   647 HSVAAHHQPTNRVNRFLSQAINARSVDCDKSEHVDRLTLRFRQSDMEREYHKDFDLGFTTAMGCS 711
                    |.:.|:.||.:||:|||:|..:.:||.:..|.|:.|.:|::|.|..|..|...:.|:
Zfish   648 --------PEDEVDEFLGRAIDARSIDQLRKDHVKKFLLTFQTSSLEKKYAKKVDDRFGGYVACT 704

  Fly   712 LLLLILGAALQVTALPRTLILLLLFLFAFIWVSAILML--------LLAVRLKWIIWDISESFSL 768
            ||:....:.:|:...|.||::|.:::..||.::.||.:        |....::.:...|.:|.:.
Zfish   705 LLVFCFISFIQIVVFPHTLVMLGIYISIFIILANILFICAIYSCVKLFPAAMQTVSKKIVQSRTN 769

  Fly   769 RMAITIFTVILIYSVGQVNVFTCVSDH-----------------PC--------SGNGTTSFQND 808
            ...:.:||:||::....||:|:|.:..                 ||        ..:|.:...|:
Zfish   770 STLVGVFTIILVFISAFVNMFSCDTQKLVDCVAKQLNWSSEMVTPCIIHNMSRSVADGLSICPNN 834

  Fly   809 SHRKCSLPQYVSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQNIFECYDNRVNA 873
            : ..|..|:|.|.|.....|:.||||::..|.|..|:|.:...:.|.:|.....:|:..|..|.|
Zfish   835 T-PSCPFPEYFSYSVLLTLLACSVFLQISSIGKLALMLLIQLTFLLLVEWPEVALFDNADLFVTA 898

  Fly   874 S--------------------------IPLHLISLARIAIFMIAILVHGRLVEGTARLDFLWQLQ 912
            :                          :.|.:::...:.:|::|:.:|.:.||.||||||||:||
Zfish   899 NALVFNETLQWSNFNTTTEQCTFRVTKVSLKVMTPVILTVFVLALYLHAQQVESTARLDFLWKLQ 963

  Fly   913 ASQEKKEMDVLQESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYT 977
            |::||:||:.||..|:|:|||:||..|||||| |:.|.|.|||:||...|.|:|||:.||:|||.
Zfish   964 ATEEKEEMEELQAYNRRLLHNILPKDVAAHFL-ARERRNDELYYQSCECVAVMFASISNFSEFYV 1027

  Fly   978 EMDGSDQGLECLRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEYKIQPND---PN 1039
            |::.:::|:|||||||||||||||::.|:::|.::||||:||||||..||        ||   ..
Zfish  1028 ELEANNEGVECLRLLNEIIADFDEIISEEKYRQLEKIKTIGSTYMAASGL--------NDSTYDK 1084

  Fly  1040 SVRRHMTALIEYVKAMRHSLQEINSHSYNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVAS 1104
            ..|.|:|||.:|...:|..::.||.||:|||.:::|:||||||||||||||||||||||||||||
Zfish  1085 EGRSHITALADYAMHLREQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVAS 1149

  Fly  1105 RMDSTGVPGYSQVTQEVVDSLVGSHFEFRCRGTIKVKGKGDMVTYFLCD 1153
            ||||||||...|||.::...|....::..|||.|||||||:|.||||.|
Zfish  1150 RMDSTGVPDRIQVTTDLHQVLHSKGYQLECRGVIKVKGKGEMTTYFLND 1198

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:318454	77/250 (31%)
		Guanylate_cyc	266..428	CDD:425528	126/161 (78%)
		Adcy_cons_dom	624..698	CDD:461877	19/73 (26%)
		AcyC	742..1150	CDD:441717	191/469 (41%)
		Guanylate_cyc	954..1151	CDD:425528	115/199 (58%)
adcy6a	XP_017209219.1	AC_N	<97..395	CDD:318454	80/266 (30%)
		Guanylate_cyc	397..559	CDD:425528	126/161 (78%)
		Adcy_cons_dom	609..697	CDD:461877	32/205 (16%)
		Guanylate_cyc	1004..1197	CDD:425528	116/200 (58%)