DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rut and adcy6a

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	XP_017209219.1	Gene:	adcy6a / 570652	ZFINID:	ZDB-GENE-060221-1	Length:	1203	Species:	Danio rerio

Alignment Length:	1219	Identity:	461/1219 - (37%)
Similarity:	664/1219 - (54%)	Gaps:	247/1219 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RPLNTLRFENDELECLYQRYTLKLQRFSVLGVVALVFVLCGVMAALSLTFNNAATFHNIFN---- 71
            |...:.:|::.:||.|||||..:|.:.|:..::.::.::||||          .|||.|..
Zfish   151 RVFQSKKFQSRKLERLYQRYFFRLNQSSLTMLMGVLVIVCGVM----------LTFHCIHGPPDV 205

  Fly    72 ------AIVCGLFAVVLVLLQCSVIKDHHLPTLCY---GILLFTASICVVSMPTLGSVFPVDTKE 127
                  ::...||..::|:...:.....::..:.|   |:|:......|:.:....:
Zfish   206 VYASVLSVAMALFLALMVVCNRNGFHQDYMWMVSYLVIGVLIIVQVFGVLMVAPRSA-------- 262

  Fly   128 VMAEGVWQIVFVVFLAYAMMPLQIWEAVAFGIALPSVHISLTVYKIFTDALRYLEYNQLIANIVI 192
              :||:|..||.:::.|.::|:::..||..|..|.::|: ||.::|..|. .:| :.||.||::|
Zfish   263 --SEGIWWSVFFIYIIYTLLPVRMRAAVLSGGVLSAIHL-LTTWRINQDD-EFL-WKQLSANVLI 322

  Fly   193 FIGVNVAGLVVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDILS 257
            |:..|:.|:..:...|.:||:.|.:||..|.:||.:|.||::.|||||||||:||||:||.||.:
Zfish   323 FLCTNIIGICTHYPAEVSQRQAFQETRGYIQARLHLQRENQQQERLLLSVLPRHVAMEMKADINA 387

  Fly   258 PVAG-QFHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKI 321
            .... .||:||||||:|||||||||.|||.|:|||:|||||..|||||.|||:||.:||||||||
Zfish   388 KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLASENHCLRIKI 452

  Fly   322 LGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRKW 386
            |||||||||||||||.|||.|.||||:|||:||:.|.|.|.|.:|||||||:|||.|||||||||
Zfish   453 LGDCYYCVSGLPEPRADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKW 517

  Fly   387 QFDVWSNDVTLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFFIVPP 451
            ||||||||||||||||:||:.||:|:|:|||..|:|:||||.|.|.||::||:::.::||.:
Zfish   518 QFDVWSNDVTLANHMEAGGKAGRIHITKATLQYLNGDYEVEPGFGGERNAYLKENSIETFLV--- 579

  Fly   452 PHRRKPLMLNTLGVRSAIGSRRKLSFRNVSNVVMQLLHTIKFSEPVPFSNIATGSFPSAASALGG 516
                             :|..:|..........||...|......|| ..:...||
Zfish   580 -----------------LGCSQKRKDEKAMMAKMQRTRTNSNEALVP-RWVPDRSF--------- 617

  Fly   517 GVSVGGGGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYGSVVGSGGG 581
                                          |.....||.|..                      |
Zfish   618 ------------------------------SRTKDSKVFRQM----------------------G 630

  Fly   582 VDSGISGGGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRHNHKNNKSQSKVADKFKRPFRKR 646
            :|                             .|:|          |:|:...:..:
Zfish   631 ID-----------------------------ETSS----------KDNRGAQEALN--------- 647

  Fly   647 HSVAAHHQPTNRVNRFLSQAINARSVDCDKSEHVDRLTLRFRQSDMEREYHKDFDLGFTTAMGCS 711
                    |.:.|:.||.:||:|||:|..:.:||.:..|.|:.|.:|::|.|..|..|...:.|:
Zfish   648 --------PEDEVDEFLGRAIDARSIDQLRKDHVKKFLLTFQTSSLEKKYAKKVDDRFGGYVACT 704

  Fly   712 LLLLILGAALQVTALPRTLILLLLFLFAFIWVSAILML--------LLAVRLKWIIWDISESFSL 768
            ||:....:.:|:...|.||::|.:::..||.::.||.:        |....::.:...|.:|.:.
Zfish   705 LLVFCFISFIQIVVFPHTLVMLGIYISIFIILANILFICAIYSCVKLFPAAMQTVSKKIVQSRTN 769

  Fly   769 RMAITIFTVILIYSVGQVNVFTCVSDH-----------------PC--------SGNGTTSFQND 808
            ...:.:||:||::....||:|:|.:..                 ||        ..:|.:...|:
Zfish   770 STLVGVFTIILVFISAFVNMFSCDTQKLVDCVAKQLNWSSEMVTPCIIHNMSRSVADGLSICPNN 834

  Fly   809 SHRKCSLPQYVSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQNIFECYDNRVNA 873
            : ..|..|:|.|.|.....|:.||||::..|.|..|:|.:...:.|.:|.....:|:..|..|.|
Zfish   835 T-PSCPFPEYFSYSVLLTLLACSVFLQISSIGKLALMLLIQLTFLLLVEWPEVALFDNADLFVTA 898

  Fly   874 S--------------------------IPLHLISLARIAIFMIAILVHGRLVEGTARLDFLWQLQ 912
            :                          :.|.:::...:.:|::|:.:|.:.||.||||||||:||
Zfish   899 NALVFNETLQWSNFNTTTEQCTFRVTKVSLKVMTPVILTVFVLALYLHAQQVESTARLDFLWKLQ 963

  Fly   913 ASQEKKEMDVLQESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYT 977
            |::||:||:.||..|:|:|||:||..|||||| |:.|.|.|||:||...|.|:|||:.||:|||.
Zfish   964 ATEEKEEMEELQAYNRRLLHNILPKDVAAHFL-ARERRNDELYYQSCECVAVMFASISNFSEFYV 1027

  Fly   978 EMDGSDQGLECLRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEYKIQPND---PN 1039
            |::.:::|:|||||||||||||||::.|:::|.::||||:||||||..||        ||   ..
Zfish  1028 ELEANNEGVECLRLLNEIIADFDEIISEEKYRQLEKIKTIGSTYMAASGL--------NDSTYDK 1084

  Fly  1040 SVRRHMTALIEYVKAMRHSLQEINSHSYNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVAS 1104
            ..|.|:|||.:|...:|..::.||.||:|||.:::|:||||||||||||||||||||||||||||
Zfish  1085 EGRSHITALADYAMHLREQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVAS 1149

  Fly  1105 RMDSTGVPGYSQVTQEVVDSLVGSHFEFRCRGTIKVKGKGDMVTYFLCD 1153
            ||||||||...|||.::...|....::..|||.|||||||:|.||||.|
Zfish  1150 RMDSTGVPDRIQVTTDLHQVLHSKGYQLECRGVIKVKGKGEMTTYFLND 1198

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	77/250 (31%)
		CYCc	230..425	CDD:214485	144/195 (74%)
		Guanylate_cyc	266..438	CDD:278633	131/171 (77%)
		DUF1053	624..696	CDD:283888	18/71 (25%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	40/209 (19%)
		CYCc	924..1134	CDD:214485	120/212 (57%)
		Guanylate_cyc	954..1151	CDD:278633	115/199 (58%)
adcy6a	XP_017209219.1	AC_N	<97..395	CDD:318454	80/266 (30%)
		Guanylate_cyc	397..570	CDD:306677	132/172 (77%)
		DUF1053	609..696	CDD:310728	32/204 (16%)
		Guanylate_cyc	1004..1197	CDD:306677	116/200 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I5105
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.710