DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rut and adcy1b

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_001161822.1	Gene:	adcy1b / 569499	ZFINID:	ZDB-GENE-100805-1	Length:	1114	Species:	Danio rerio

Alignment Length:	1274	Identity:	506/1274 - (39%)
Similarity:	715/1274 - (56%)	Gaps:	232/1274 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VKATRGR---PLNTLRFEND----ELECLYQRYTLKLQRFSVLGVVALVFVLCGVMAALSLTFNN 62
            ||..|.|   |..|:..|::    |||.|::||.|||::.:.|..::::.:|...::.|.|..:.
Zfish     9 VKTRRRRSHCPPGTIACEDEFDCAELEALFRRYRLKLEQTATLKALSVLILLSCSLSLLELLLSG 73

  Fly    63 -----AATFHNIFNAIVCGLFAV--VLVLLQCSVIKDHHLPTLCYGILLFTASICVVSMPTLGSV 120
                 |...|.:.:.:...||.|  |..||...:.:..|| :|.:|   ||.::....:|.:...
Zfish    74 TGLSVAQGSHPVHSVLFISLFIVTNVQYLLVTQLQQIAHL-SLLFG---FTFAVPCCPLPQVSRA 134

  Fly   121 FPVDTKEVMAEGVWQIVFVVFLAYAMMPLQIWEAVAFGIALPSVHISLTVYKIFTDALRYLEYNQ 185
            ...:      :|||.::.:.|:||.::|::...|:.||:.||..|..:|...:..:..|.  :..
Zfish   135 AGPE------QGVWPLLLLTFMAYCLLPVRTGLALLFGLLLPLAHTLITASTLPDNTQRL--WRS 191

  Fly   186 LIANIVIFIGVNVAGLVVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQ 250
            |:||.::|.||||:||.|.|:.|||||:.||..||||..||.::|||||.||||:|:||::|||:
Zfish   192 LVANTLLFTGVNVSGLFVRILTERAQRKAFLQARNCIEERLRMEDENEKQERLLMSLLPRNVAME 256

  Fly   251 MKNDILSPVAGQFHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNH 315
            ||.|.|.|....||:||||:|:|||||||||||.|.|:|||:|||||:|||||||:||:||.:||
Zfish   257 MKEDFLKPPERIFHKIYIQRHDNVSILFADIVGSTSLASQCTAQELVKLLNELFGKFDELATENH 321

  Fly   316 CLRIKILGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGV 380
            |.|||||||||||||||.:|:.|||.|.|||||||||.|.:|.|||:|.||||||:|||||||||
Zfish   322 CRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGV 386

  Fly   381 LGLRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDT 445
            |||||||:|||||||||||.||:||.||:||:||:||:.|:|:||||.|:|.||.::|..|.::|
Zfish   387 LGLRKWQYDVWSNDVTLANMMEAGGLPGKVHITRSTLECLNGDYEVEPGNGRERHAFLLKHDIET 451

  Fly   446 FFIVPPPHRRK--PLMLNTLGVRSAIGSRRKLSFRNVSNVVMQLLHTIK-FSEPVPFSNIATGSF 507
            |||| ||||||  |.:     :.|.|...:|:.|:.|..:::||:|..| |...:||||:
Zfish   452 FFIV-PPHRRKIFPGL-----ILSDIKPAKKMKFKTVCYLLVQLMHCRKMFRAEIPFSNV----- 505

  Fly   508 PSAASALGGGVSVGGGGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRL--QKILHATPPPHGM 570
                                       ..||         :...|:|:|.  :|:.:.||
Zfish   506 ---------------------------MNCE---------DGDKRRVLRSAPEKLRNRTP----- 529

  Fly   571 GYGSVVGSGGGVDSGISGGGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRHNHKNNKSQSKV 635
                                               |..:.|.|:
Zfish   530 -----------------------------------TAASAPQSS--------------------- 538

  Fly   636 ADKFKRPFRKRHSVAAHHQPTNRVNRFLSQAINARSVDCDKSEHVDRLTLRFRQSDMEREYHKDF 700
                               |..||||::::.|.||..:.|.:: ::.|||.:|.|:.||.||:..
Zfish   539 -------------------PGTRVNRYINRLIEARQTESDTAD-LNYLTLMYRDSERERRYHQLN 583

  Fly   701 DLGFTTAMGCSLLLLILGAALQVTALPRTLILLLLFLFAFIWVSAILMLLLAVRLKWIIWDISES 765
            |..||.|:..||||::|...|.:..:|:..::|:|.:|...::...:|.|...|::.....:  :
Zfish   584 DEYFTGAVVLSLLLVVLLGFLYLLIIPQGTVVLVLLVFCICFLVVCIMYLHITRVQCFPGCL--T 646

  Fly   766 FSLRMAITIFTVILIYSVGQVNVFTCVSDHP--CSGNGTTSF----------QNDSHRKCSLPQY 818
            ..:|.|:.:|.|:|||:|.|..|..|:   |  ...|.|.|.          :..:...|:..||
Zfish   647 IQIRTALCVFIVLLIYAVAQACVVGCM---PWLWPSNSTRSIVIIDAAAGLNRTMAELPCAGAQY 708

  Fly   819 VSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQNIFECYDNRVNASIPLHLISLA 883
            ..|......||:::|||:..|.|::|:|.:..:|...:|||.   |.........|: ..|..|.
Zfish   709 AFLCCMLGTLSMALFLRVSWIPKTILLLLLLVLYITILELSG---FRRASGWALLSV-RGLEPLL 769

  Fly   884 RIAIFMIAILVHGRLVEGTARLDFLWQLQASQEKKEMDVLQESNKRILHNLLPAHVAAHFLDAQF 948
            .:.:|..|:.:|.|.::...||||||..||.:|:..|:.::..|||||.||||.|||.|||.:..
Zfish   770 SLLLFSTAVALHSRQLDLKLRLDFLWATQAEEERDGMEKVKLDNKRILFNLLPVHVAQHFLLSNP 834

  Fly   949 RNNMELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGLECLRLLNEIIADFDELLKEDRFRGIDK 1013
            | ||:||:||||:|||:|||:||||:||.|:||::.|:||||||||||||||||:.::.::.|:|
Zfish   835 R-NMDLYYQSYAQVGVLFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMDKECYKDIEK 898

  Fly  1014 IKTVGSTYMAVVGLIPEYKIQPNDPNSVRRHMTALIEYVKAMRHSLQEINSHSYNNFMLRVGINI 1078
            |||:|||||:.|||:|  .|......|...|::.:.::...|...|.|||..|||:|:||||||:
Zfish   899 IKTIGSTYMSAVGLVP--TIGTKAKKSTATHLSTIADFAIEMFDVLDEINYQSYNDFVLRVGINV 961

  Fly  1079 GPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYSQVTQEVVDSLVGSHFEFRCRGTIKVKGK 1143
            |||||||||||:|||||||||||||||||||||||..|||::|. .|:.::::..|||.:.||||
Zfish   962 GPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVPGKIQVTEDVY-RLLQNNYDLMCRGNVSVKGK 1025

  Fly  1144 GDMVTYFL--------------------------CDSGNKSLNGEVRNAMS-------LPQSLHA 1175
            |.|:||||                          ..|..::..|.|.:|.|       |..|.|.
Zfish  1026 GQMLTYFLEGKAQDPGIRAPHHTGGLERRVHAIARTSSTQTKAGSVSSATSGLAVRVGLSSSFHG 1090

  Fly  1176 PDYYMKVSQFPENRVNTDTYSKKENGHLYAGNGVEEQQL 1214
            |..:       .|..|..|..::|.        .:||::
Zfish  1091 PHGH-------SNTTNVPTVGEEEE--------TKEQEV 1114

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	86/248 (35%)
		CYCc	230..425	CDD:214485	144/194 (74%)
		Guanylate_cyc	266..438	CDD:278633	130/171 (76%)
		DUF1053	624..696	CDD:283888	16/71 (23%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	41/162 (25%)
		CYCc	924..1134	CDD:214485	127/209 (61%)
		Guanylate_cyc	954..1151	CDD:278633	120/196 (61%)
adcy1b	NP_001161822.1	AC_N	<128..270	CDD:292831	61/149 (41%)
		CYCc	236..431	CDD:214485	144/194 (74%)
		Guanylate_cyc	272..454	CDD:278633	134/181 (74%)
		DUF1053	498..585	CDD:283888	33/208 (16%)
		CYCc	806..1012	CDD:214485	128/209 (61%)
		Guanylate_cyc	839..1035	CDD:278633	122/198 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	273	1.000	Domainoid score	I1755
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	840	1.000	Inparanoid score	I426
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D46761at33208
OrthoFinder	1	1.000	-	-		FOG0006927
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9671
SonicParanoid	1	1.000	-	-		X5020
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.860