DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rut and adcy2a

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	XP_692173.5	Gene:	adcy2a / 563724	ZFINID:	ZDB-GENE-061109-1	Length:	1155	Species:	Danio rerio

Alignment Length:	1209	Identity:	436/1209 - (36%)
Similarity:	621/1209 - (51%)	Gaps:	226/1209 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LYQRYTLKLQRFSVLGVVALVFVLCGVMAALSLTF--------NNAATFHNIFNAIVCGLFAVVL 82
            ||..|....|:..:  :|.|:.::.|...||...|        ::.|....:..|:...|...||
Zfish    92 LYDSYHRMSQQHPL--IVFLLLIVMGACLALLAVFFASGLDIEDHVAFVITVPTALAIFLTIFVL 154

  Fly    83 VLLQCSVIKDHHLPTLCYGILLFTASI----CVVSMPTL-----GSVFPVDTKEVMAEGVWQIVF 138
            |.:: ||.|.          ||...|:    |:|:|..|     |.:.|.|.       |...:|
Zfish   155 VCIE-SVFKK----------LLRVFSLVIWGCLVAMGYLFMFFGGIICPWDQ-------VSFFLF 201

  Fly   139 VVFLAYAMMPLQIWEAVAFGIALPSVH-ISLTVYKIFTDALRYLE--YNQLIANIVIFIGVNVAG 200
            ::|:.|.|:|..:.:|:...:...|.| :.|:|  ..:..:.::|  ..|::||::|||..||||
Zfish   202 IIFVVYTMLPFSMRDAIIASVLTASSHTVVLSV--CLSSTVSHVEPLVWQILANVIIFICGNVAG 264

  Fly   201 LVVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDIL----SPVAG 261
            .....:||.|.::|:.||.|||.|.::::.|..:.||||||:||.|:|..||.:|:    .|..|
Zfish   265 AYHKHLMELALKQTYQDTCNCIKSPIKLEFEKRQQERLLLSLLPAHIARVMKAEIIQRLQGPKFG 329

  Fly   262 Q------FHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIK 320
            |      ||.:|:|:|.|||||:|||||||.|:|.||..|||.:||||||:|||:|.:|.|:|||
Zfish   330 QVENTNNFHNLYVQRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIK 394

  Fly   321 ILGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRK 385
            ||||||||||||||...:|||..|:|||||.:||..|.:||.|.::||||:|:|.|||||:||:|
Zfish   395 ILGDCYYCVSGLPESLPNHAKNCVKMGLDMCEAIKKVRDATGVEISMRVGVHSGNVLCGVIGLQK 459

  Fly   386 WQFDVWSNDVTLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFFIVP 450
            ||:||||:|||||||||:||.|||||:|..||:.|:|.|:||.|||.||..||::|||.|:.::.
Zfish   460 WQYDVWSHDVTLANHMEAGGVPGRVHITSETLEHLNGAYKVEDGHGQERDPYLKEHGVITYLVIN 524

  Fly   451 PPHRRKPLMLNTLGVRSAIGSRRKLSFRNVSNVVMQLLHTIKFSEPVPFSNIATGSFPSAASALG 515
            |...||..........:..|::.:.|.|     :.:.|.:  :....||:|:
Zfish   525 PKVERKSPQHYYRPRHTIDGAKMRASVR-----MTRYLES--WGAAKPFANL------------- 569

  Fly   516 GGVSVGGGGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYGSVVGSGG 580
                                    :..:...:|.|        ||..|..|
Zfish   570 ------------------------HHRDSMTNENG--------KINTADVP-------------- 588

  Fly   581 GVDSGISGGGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIH-RHNHKNNKSQSKVADKFKRPFR 644
                                                 |.:.| :...:..|||.|   :|:....
Zfish   589 -------------------------------------IGQYHFQRRSERTKSQKK---RFEEELN 613

  Fly   645 KRHSVAAHHQPTNRVNRFLSQAINARSVDCDKSEHVDRLTLRFRQSDMEREYHKDFDLGFTTAMG 709
            :|           .:..|  ..||::. ...|||.:.|::|.|....:|:||.......|...:.
Zfish   614 ER-----------MIRTF--DGINSQK-QWLKSEDIQRISLFFHNKALEKEYRATTLPAFKYYIT 664

  Fly   710 CSLLLLILGAALQVTALPRTLILLLLFLFAFIWVSAILMLLL---------AVRLKWIIWDISES 765
            |:.|:......:|:..||:|.||.:.|..:|:.:|.||::..         .....| :|.:..|
Zfish   665 CACLIFFCIFIVQILVLPKTAILGVSFGMSFLILSVILLVCFIGHFLQCKKTASASW-VWILRSS 728

  Fly   766 FSL------RMAITIFTVILIYSVGQVNVF-----TCVSDHPCSGNGTTSFQNDSH-------RK 812
            ..:      |:.:|:.|..||..:...|:|     ..:.:...:.:..|..|.|..       ..
Zfish   729 GIIASKPWPRITLTMATTALILIMAVFNMFFIEDNLTLMETVYNTSNETLLQPDGQPIPYLDKNT 793

  Fly   813 CSLPQYVSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQNIFECYD--------- 868
            ..||.:: .|.....:|.|||||:....|.|::|....:|.:.|..:|.::.:.|.
Zfish   794 FYLPYFI-YSCILGLISCSVFLRINYELKMLIMLTAVVLYSVIILQTHASLLDEYSKFLYKTEVI 857

  Fly   869 NRVNASIPLHLISLARIAIFMIAILVHGRLVEGTARLDFLWQLQASQEKKEMDVLQESNKRILHN 933
            .|......|..:....:.||.|.:||..|..|...||||||:.:..:|.:|::.::..|:.:|.|
Zfish   858 ERPGVLKDLKTMGSVSLFIFFITLLVLARQNEYYCRLDFLWKNKFKKECEEIETMENLNRVLLEN 922

  Fly   934 LLPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGLECLRLLNEIIAD 998
            :||||||.|||...::|. :||||||..|.|:|||:|:|.|||||.|.:.:||||||||||||||
Zfish   923 VLPAHVAEHFLARNWKNE-DLYHQSYDLVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIAD 986

  Fly   999 FDELLKEDRFRGIDKIKTVGSTYMAVVGLI----PEYKIQPNDPNSVRRHMTALIEYVKAMRHSL 1059
            |||||.:.:|.|::||||:||||||..||.    ||| .|.:|...:  |:..::|:..|:...|
Zfish   987 FDELLSKPKFSGVEKIKTIGSTYMAATGLNATPGPEY-TQEHDRQYM--HIGTMVEFAFALVGKL 1048

  Fly  1060 QEINSHSYNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYSQVTQEVVDS 1124
            ..||.||:|:|.||||||.|||.||||||:||||||||||||||||||||||.|..|||:|....
Zfish  1049 DVINKHSFNDFKLRVGINHGPVKAGVIGAQKPQYDIWGNTVNVASRMDSTGVLGKIQVTEETSCI 1113

  Fly  1125 LVGSHFEFRCRGTIKVKGKGDMVTYF----LCDS---GN 1156
            |....:...|||.|.|||||::.|||    :|.|   ||
Zfish  1114 LQTLGYTCSCRGIINVKGKGELKTYFVHTEMCRSLSQGN 1152

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	74/248 (30%)
		CYCc	230..425	CDD:214485	126/204 (62%)
		Guanylate_cyc	266..438	CDD:278633	115/171 (67%)
		DUF1053	624..696	CDD:283888	16/71 (23%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	37/186 (20%)
		CYCc	924..1134	CDD:214485	123/213 (58%)
		Guanylate_cyc	954..1151	CDD:278633	122/204 (60%)
adcy2a	XP_692173.5	AC_N	<92..319	CDD:292831	74/248 (30%)
		CYCc	295..498	CDD:214485	126/202 (62%)
		Guanylate_cyc	340..524	CDD:278633	121/183 (66%)
		DUF1053	554..658	CDD:283888	30/218 (14%)
		CYCc	912..1120	CDD:214485	123/211 (58%)
		Guanylate_cyc	942..1141	CDD:278633	122/201 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.710