DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rut and adcy5

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_001165056.1	Gene:	adcy5 / 562619	ZFINID:	ZDB-GENE-081104-470	Length:	1186	Species:	Danio rerio

Alignment Length:	1199	Identity:	467/1199 - (38%)
Similarity:	675/1199 - (56%)	Gaps:	219/1199 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 RFENDELECLYQRYTLKLQRFSVLGVVALVFVLCGVMAALSLTFNNAA-----TFHNIFNAIVCG 76
            :|::::||.|||||..:|.:.|:..::|::.::|.||    |.|:.|.     ||..:|.|.:..
Zfish   150 KFQSEKLERLYQRYFFRLNQSSLTMLMAVLVLVCAVM----LGFHCAGGMCQLTFVLVFTAAIVL 210

  Fly    77 LFAVVLVLLQCSVIKDHHLPTLCYGILLFTASICVVSMPTLGSVFPVDTKEVMAEGVWQIVFVVF 141
            :..:::|..:.|..:| |:..:||.::|...::.||     |.:| |..:.. :||:|..||.:.
Zfish   211 ILTLMVVCNRNSFHQD-HMWIVCYLLILLVLAVQVV-----GVLF-VKPRSA-SEGIWWTVFFIH 267

  Fly   142 LAYAMMPLQIWEAVAFGIALPSVHISLTVYKIFTDALRYLEYNQLIANIVIFIGVNVAGLVVNIM 206
            :.|.::|:::..||..||.|.::|: |..::: .|...:| :.||::|::||...|:.|:..:..
Zfish   268 VIYTLLPVRMRAAVITGIILSAIHV-LISWRL-NDMDVFL-WKQLVSNVLIFSCSNIVGVCTHYP 329

  Fly   207 MERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDILSPVAG-QFHRIYIQK 270
            .|.:||:.|.:||.||.:||..|.||::.|||||||||:|||::||.||.:.... .||:|||||
Zfish   330 AEGSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVALEMKADINAKQEDMMFHKIYIQK 394

  Fly   271 HENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYYCVSGLPEP 335
            |:|||||||||.|||.|:|||:|||||..|||||.|||:||.:|||||||||||||||||||||.
Zfish   395 HDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEA 459

  Fly   336 RKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDVTLANH 400
            |.|||.|.||||:|||:||:.|.|.|.|.:|||||||:|||.|||||||||||||||||||||||
Zfish   460 RADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANH 524

  Fly   401 MESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFFIVPPPHRRKPLMLNTLGV 465
            ||:||:.||:|:|:|||:.|:|:|:||.|.|.||:.||:.|.::|:.||....:||
Zfish   525 MEAGGKAGRIHITKATLNYLNGDYDVEPGSGGERNVYLKKHNIETYLIVGCSQKRK--------- 580

  Fly   466 RSAIGSRRKLSFRNVSNVVMQLLHTIKFSEPVPFSNIATGSFPSAASALGGGVSVGGGGGGGGGG 530

Zfish   581 ----------------------------------------------------------------- 580

  Fly   531 VARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYGSVVGSGGGVDSGISGGGGCVSG 595
                            .||.  .:.::.:
Zfish   581 ----------------EEKA--MIAKMNR------------------------------------ 591

  Fly   596 GIAGGGGVQVTVGTNPNSTASTISRIHRHNHKNNKSQSKVADKFKRPFRKRHSVAAHHQPTNRVN 660
                    |.|.....|||..|....:.|.:.|:.|:......|:.|  |..:...:..|.:.|:
Zfish   592 --------QRTNSVTHNSTHWTDRPFYNHLNANSVSKEMKRMGFEDP--KDKNTQENLNPEDEVD 646

  Fly   661 RFLSQAINARSVDCDKSEHVDRLTLRFRQSDMEREYHKDFDLGFTTAMGCSLLLLILGAALQVTA 725
            .||.:||:|||:|..:||||.:..|.||:.|:|::|.|..|..|...:.|:.|:.:....:|:..
Zfish   647 EFLGRAIDARSIDRLRSEHVKKFLLTFREPDLEKKYSKQVDSSFGAYVACASLVFLFICFIQIII 711

  Fly   726 LPRT------LILLLLFLFAFIWVSAILML--LLAVRLKWIIWDISESFSLRMAITIFTVILIYS 782
            :|.:      .:|.|:.|...:::|||...  ...:.|:.:...|.:|......:.:||::|::.
Zfish   712 VPHSGLMVGFYVLCLVVLMVVMFISAIYSCFGFFPIPLQTLSKRIVQSRLNSTLVGVFTIVLVFI 776

  Fly   783 VGQVNVFTCVSD----------------------HPCSGNGTTSFQ----NDSHRKCSLPQYVSL 821
            ...:|:|||.:|                      |..|.|.|...|    |.|...|:.|:|.|.
Zfish   777 SAFINIFTCSTDDLKTCLGQEFNISPSNVNACHAHFSSLNYTLWSQNRLCNSSSPTCNFPEYFSS 841

  Fly   822 SAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQNIFECYDNRVNAS------------ 874
            ....:.|:.||||::..|.|..|:|.:..:|.|.:|:...::|:..|..|.|:
Zfish   842 CVLLSLLACSVFLQVSSIGKLFLMLFIEILYVLIMEVPEVSLFDNVDLLVMANALAPNNGTCIVD 906

  Fly   875 --IPLHLISLARIAIFMIAILVHGRLVEGTARLDFLWQLQASQEKKEMDVLQESNKRILHNLLPA 937
              :||.:::...|.:|::|:.:|.:.||.||||||||:|||::||:||:.||..|:|:|||:||.
Zfish   907 TRVPLKIVTPVVITVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPK 971

  Fly   938 HVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGLECLRLLNEIIADFDEL 1002
            .|||||| |:.|.|.|||:||...|.|:|||:.||:|||.|::.:::|:|||||||||||||||:
Zfish   972 DVAAHFL-ARERRNDELYYQSCECVAVMFASISNFSEFYVELEANNEGVECLRLLNEIIADFDEI 1035

  Fly  1003 LKEDRFRGIDKIKTVGSTYMAVVGLIPEYKIQPND---PNSVRRHMTALIEYVKAMRHSLQEINS 1064
            :.||:||.::||||:||||||..||        ||   ..:.|.|:.||.:|...:...::.||.
Zfish  1036 ISEDQFRQLEKIKTIGSTYMAASGL--------NDSTYDKAGRSHIRALADYAMRLMDQMKYINE 1092

  Fly  1065 HSYNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYSQVTQEVVDSLVGSH 1129
            ||:|||.:::|:|:||||||||||||||||||||||||||||||||||...|||.::...|...:
Zfish  1093 HSFNNFKMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPERIQVTTDLYQVLSSYN 1157

  Fly  1130 FEFRCRGTIKVKGKGDMVTYFLCDSGNKS 1158
            :....||.:||||||:|:||||....|.|
Zfish  1158 YTLEYRGVVKVKGKGEMMTYFLNGGPNNS 1186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	83/242 (34%)
		CYCc	230..425	CDD:214485	142/195 (73%)
		Guanylate_cyc	266..438	CDD:278633	129/171 (75%)
		DUF1053	624..696	CDD:283888	25/71 (35%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	46/192 (24%)
		CYCc	924..1134	CDD:214485	119/212 (56%)
		Guanylate_cyc	954..1151	CDD:278633	112/199 (56%)
adcy5	NP_001165056.1	AC_N	1..388	CDD:292831	85/252 (34%)
		CYCc	354..548	CDD:214485	142/193 (74%)
		Guanylate_cyc	390..574	CDD:278633	134/183 (73%)
		DUF1053	598..687	CDD:283888	31/90 (34%)
		CYCc	961..1155	CDD:214485	118/202 (58%)
		Guanylate_cyc	987..1181	CDD:278633	114/201 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I5105
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.710