DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rut and gucy1a1

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_001296458.1	Gene:	gucy1a1 / 550420	ZFINID:	ZDB-GENE-050417-230	Length:	679	Species:	Danio rerio

Alignment Length:	494	Identity:	112/494 - (22%)
Similarity:	194/494 - (39%)	Gaps:	154/494 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 TLKLQRFSVLGVVALVFVLC-----GVMAALSLTFNNAATFHNIFNAIVCGLFAVVLVLLQCSVI 90
            |.::||:     :....:||     |:   |::.|.|......:|   ..|:......||.|:.:
Zfish   179 TPEIQRY-----IHQASILCLDKDPGL---LTVYFFNPLPSTELF---FSGIIQAAACLLYCTRV 232

  Fly    91 --------KD------HHLPTLCYGIL-----------LFTASICVVSMPTLGSVFPVDTKEVMA 130
                    ||      .|.|.|.|.::           :.|.:...:.:..|.|.||
Zfish   233 EVRMDVGGKDSGALQADHQPHLLYSVVVRDGRSLTPSPMRTHTSGDIPLSLLYSTFP-------- 289

  Fly   131 EGVWQIVFVVFLAYAMMPLQIWEAVA------------------FGIALPSVHISLTVYKIFTDA 177
                   |.:.|...|..|||.:.:.                  |.|..|.:..|      |.|.
Zfish   290 -------FHILLDQEMGLLQIGDGLRRRLGRCRDGQRRPAFNEHFAIVSPEIRAS------FQDI 341

  Fly   178 LRYLEYNQLI----------------------------ANIVIFIG---------VNVAGLVV-N 204
            |..|....|:                            .:.::|:|         :...||.: :
Zfish   342 LTMLNTQFLLRVKQHGASSADSPGKHMDLKGQMIFMSEMSALLFLGSPCVDKLEELTGRGLYLSD 406

  Fly   205 IMMERAQRRTFL-----DTRNCIASRL------------EIQDENEKLERLLLSVLPQHVAMQMK 252
            |.:..|.|...|     ..::.:..||            .:::|..:...||.::.|.:||.::.
Zfish   407 IPIHNALRDVVLVGEQTKAQDGLKKRLGKAKAALEQAHQALEEEKRRTVELLFTIFPGNVAQRLW 471

  Fly   253 NDILSPVAGQFHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHC- 316
            ..:  ||..       :|.::|::||:||||||.:.|:|:..::|.:|:||:.||     |:||
Zfish   472 QGL--PVQA-------KKFDHVTVLFSDIVGFTAICSRCTPMQVVNMLSELYTRF-----DHHCG 522

  Fly   317 ----LRIKILGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVL 377
                .:::.:||.|....||.:....||.....|.|.|::....|......::.||:|||:|.||
Zfish   523 ELDVYKVETIGDAYCVAGGLHKESPTHAVQIALMALKMMELSDEVTTPMGEVIRMRIGIHSGSVL 587

  Fly   378 CGVLGLRKWQFDVWSNDVTLANHMESGGEPGRVHVTRAT 416
            .||:|::..::.::.|:|||||..||...|.:::|:..|
Zfish   588 AGVVGVKMPRYCLFGNNVTLANKFESCSLPRKINVSPTT 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	56/326 (17%)
		CYCc	230..425	CDD:214485	62/192 (32%)
		Guanylate_cyc	266..438	CDD:278633	54/156 (35%)
		DUF1053	624..696	CDD:283888
		SLC5-6-like_sbd	<742..>893	CDD:294310
		CYCc	924..1134	CDD:214485
		Guanylate_cyc	954..1151	CDD:278633
gucy1a1	NP_001296458.1	HNOBA	279..470	CDD:285003	35/211 (17%)
		CYCc	449..635	CDD:214485	62/192 (32%)
		Guanylate_cyc	476..647	CDD:278633	55/163 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810