Protein Alignment rut and ACXE

DIOPT Version :10

• Sequence 1: NP_511156.2
• Gene: rut / 32406
• FlyBaseID: FBgn0003301
• Length: 2248
• Species: Drosophila melanogaster
• Sequence 2: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Alignment Length: 1317
• Identity: 316/1317 - (23%)
• Similarity: 526/1317 - (39%)
• Gaps: 349/1317 - (26%)

  Fly    23 LECLYQRYTLKLQRFSVLGVVALVFVLCGVMAALSLTF--NNAATFHNIFNAIVCGLFAVVLVLL 85
            ||..::.|.::|.:..:|....|...:..|..||.|..  ..:..:.::..:|.|.|..::::.:
  Fly    32 LESEFRLYRIRLWKSYLLTFFMLHIFVTSVHCALLLATIERRSIIYFDVALSIGCALVLILVLSV 96

  Fly    86 Q-CSVIKDHHLPTLCYGILLFTASICVVSMPTLGSVFPVDTKEVMAEGVWQIVFVVFLAYAMMPL 149
            . |......| ....|...:| ||:.:|......|::.......:. |.:...:::::.|..:|:
  Fly    97 NFCDEFIAKH-TWYMYASSIF-ASLTLVFADLTESIYHTYAHSWIL-GTFYDTYIIYMIYMFLPI 158

  Fly   150 Q-IWEAVAFGIALPSVHISLTVYKI------FTDALRYLEYNQLIANIVIFIGVNVAGLVVNIMM 207
            . |..||...:.:..::|...|..|      |..||  .....:..:||.::.:|:.|:...:|.
  Fly   159 HFISGAVLLALLVSGLYILYFVIFIAQGFAQFASAL--FSVGGMSVDIVHYLCLNLVGIFYRVMN 221

  Fly   208 ERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDILSPVAGQFHRIY----- 267
            :...|.:|||....|..::.:::...:.::||.|:||..:::.::.||...:......|:
  Fly   222 DTVVRSSFLDRHQYIKEKIWLRNARLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAM 286

  Fly   268 -----IQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYY 327
                 ||.|.:||||:||:|.:|.|::..:.:.||::|::|:||||..|:.....|||.||||||
  Fly   287 ERTMAIQIHPDVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYY 351

  Fly   328 CVSGLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWS 392
            ||:||.:|..|||...|.:||.||:.|..|.:...:.:|||:|:|:|.:..||:|..|.|||:|.
  Fly   352 CVAGLSDPDPDHANNCVILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWG 416

  Fly   393 NDVTLANHMESGGEPGRVHVTRATLDSLS-GEYEVEAGHGDERS-SYLRDHGVDTFFIVPPPHRR 455
            .|||:||.:||.|.||.||::.|||::|. ..:::|.|..:.|. ..|:.:.:.::.|      |
  Fly   417 LDVTIANVLESTGVPGCVHISGATLNNLDVNRFDIEDGPEEARDHPLLKKYRIRSYII------R 475

  Fly   456 KPLMLNTLGVRSAIGSRRKLSFRN------VSNVVMQLLHTIKFSEPV--PFSNIATGSFPSAAS 512
            :.|.::.......:|....:|..|      :|:...|.|..: |.|.:  .|..:...:| |...
  Fly   476 QDLHMDDEDSDEFLGDLHSISLCNMGAQPRISDSANQSLRAL-FHEELREEFRKMPVSAF-SPKR 538

  Fly   513 ALGGGVSVGGGGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYGSVVG 577
            .||                    .|..|:|.
  Fly   539 LLG--------------------ICRFNTGK---------------------------------- 549

  Fly   578 SGGGVDSGISGGGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRHNHKNNKSQSKVADKFKRP 642
                                                                             
  Fly   550 ----------------------------------------------------------------- 549

  Fly   643 FRKRHSVAAHHQPTNRVNRFLSQAINARSVDCDKSEHVDRLTLRFRQSDMEREYHKDFDLGF--- 704
                 .|.||            |.:|              :.|.|....:||.|.|..|..:
  Fly   550 -----EVPAH------------QNLN--------------ICLTFTDPILERAYLKQTDYMYKYS 583

  Fly   705 ---TTAMGCSLLLLILGAALQVTA----LPRTLILLLLFLFAFIWVSAILMLLLAVRLKWIIW-- 760
               :.::||||:.:.|.....:.:    ||.::..:...|....|            .|...|
  Fly   584 IILSASVGCSLVYIELMDTQMICSSCFVLPASVATIQCILALIAW------------YKKYCWTR 636

  Fly   761 ----------------------DISESFSLRMAITIFTVILIYSVGQVNVFTCVSD--------- 794
                                  .|..|..:|:.|.:|.:|..:.|..:.|.:|..:
  Fly   637 YGRNNVPHHYNGFSCFIFRIHDKILNSLPIRICIYLFLMISSFFVMCLIVMSCQREEFEMAYIEE 701

  Fly   795 ---HPCSGNGTTSFQNDSHRKCSLP----QYVSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIY 852
               |         ::.::| .|..|    ..:||.....|    .|..:||:.|:.:.:.....|
  Fly   702 RLFH---------YEQEAH-ICFHPWVTTNMLSLMICLTF----TFAHIPIMVKTAVAILETLAY 752

  Fly   853 GLFIELSHQNIFECYDNRVNASIPLHLISLARIAIFMIAILVHGRLVEGTARLDFLWQLQASQEK 917
            .|.|......:|. :....|............|.|..:.:.|..|.:|.|.:::|.|::...:|:
  Fly   753 LLLIFFQFDFVFH-HSVTTNPYFKSEYAHALLICITFLIMFVKERQIEFTNKVNFNWRVDLRKEE 816

  Fly   918 KEMDVLQESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYTEMDGS 982
            ....:...|...||:|:||:|:...:|::..::  |||.::|..|.|:||.:.||     |||
  Fly   817 NAASLTNHSIIIILNNILPSHIVDVYLNSLAKH--ELYFENYRMVSVMFAMLINF-----EMD-- 872

  Fly   983 DQGLECLRLLNEIIADFDELL---KEDRFRGIDKIKTVGSTYMAVVGLIPEY----------KIQ 1034
               |..||:||||||:||.||   ||  :..::|||.||.||||..||...:          .|.
  Fly   873 ---LRSLRVLNEIIAEFDTLLLFYKE--YYTVEKIKIVGCTYMAACGLDLNFAGSTSTNRKESIP 932

  Fly  1035 PNDPNSVRRH--------------MTALIEYVKAMRHSLQEINSHSYNNF---------MLRVGI 1076
            |.:.|..:..              :..:..|...|..:|.:.| .:|.:.         .:.:||
  Fly   933 PTEFNEEQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKSN-EAYQSIAGDRNITDGTIAIGI 996

  Fly  1077 NIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYSQVTQEVVDSLVGSHFEFRC--RGTIK 1139
            :.|.|:||::||.:|.||||||.||:||||:|||:||:..||:|..:.|  ..|...|  ||...
  Fly   997 SSGEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEETSEIL--QQFGITCSYRGMTF 1059

  Fly  1140 VKGKGDMVTYFLCDSGNKSLNGEVRNAMSLPQSLHAPDYYMKVSQFPENRVNT------DTYSKK 1198
            |||:|.:.||         |.|...|...:||         |.::||.::..:      .||:..
  Fly  1060 VKGRGKIPTY---------LVGIDENLNFIPQ---------KATRFPSHQERSTVISLQSTYTHA 1106

  Fly  1199 ENGHLYAGNGVEEQQLL 1215
            ||.:..|.......|.|
  Fly  1107 ENNNSIASTSRHTLQSL 1123

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:318454	48/241 (20%)
		Guanylate_cyc	266..428	CDD:425528	76/172 (44%)
		Adcy_cons_dom	624..698	CDD:461877	10/73 (14%)
		AcyC	742..1150	CDD:441717	131/485 (27%)
		Guanylate_cyc	954..1151	CDD:425528	86/234 (37%)
ACXE	NP_652601.3	AcyC	65..453	CDD:441717	118/392 (30%)
		Nucleotidyl_cyc_III	290..459	CDD:448371	77/168 (46%)
		Nucleotidyl_cyc_III	851..1071	CDD:448371	86/243 (35%)