DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rut and Phlpp2

DIOPT Version :9

Sequence 1:NP_511156.2 Gene:rut / 32406 FlyBaseID:FBgn0003301 Length:2248 Species:Drosophila melanogaster
Sequence 2:NP_001102601.2 Gene:Phlpp2 / 498949 RGDID:1562857 Length:1359 Species:Rattus norvegicus


Alignment Length:1506 Identity:266/1506 - (17%)
Similarity:429/1506 - (28%) Gaps:587/1506 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   390 VWSNDVTLA--------NHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTF 446
            ::..|.|.|        :...|......:|:...|:::.:.  |:.||.|.| |.||:.|| |..
  Rat    70 LYGADTTTATTTTTSSSSSSSSSSSSSDLHLVLCTVETPAS--EICAGEGRE-SLYLQLHG-DLV 130

  Fly   447 FIVPPPHRRKPLMLNTLGVRSAIGSRRKLSFRNVSNVVMQLLHTIKFSEPVPFSNIAT------- 504
            ..:.|..|  ||                       .:|...|..:.|.:||.....||       
  Rat   131 RRLEPTER--PL-----------------------QIVYDYLSRLGFEDPVRIQEEATNPDLSCM 170

  Fly   505 ----GSFPSAASALGGGVSVGGGGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKILHATP 565
                |..|.....|              ..:..........|..|:.:...|.|:..        
  Rat   171 IRFYGEKPCQMDHL--------------DRILLSGIYNVRKGKTQLHKWAERLVVLC-------- 213

  Fly   566 PPHGMGYGSVVGSGGGVDSGISGGGGCVSG-----GIAGGGGVQVTVGTNPNSTASTISRIHRHN 625
                           |....:|....|.:|     .:.||                .|..:.|..
  Rat   214 ---------------GTCLIVSSVKDCQTGKMHILPLVGG----------------KIEEVKRRQ 247

  Fly   626 HK-NNKSQSKVADKFKRPFRKRHSVAAHHQPTNRVNRFLSQAINARSVDCDKSEHVDR------- 682
            |. ...|....|..:...|   .::|.:.:...:.::.:||.|:...:.|...|.|..       
  Rat   248 HSLAFSSAGAQAQTYHVSF---ETLAEYQRWQRQASKVVSQRISTVDLSCYSLEEVPEHLFYSQD 309

  Fly   683 ---LTLRFRQSDMEREYHKDFDLGFTTAMGCSLLLLILGAALQVTALPRTLILLLLFLFAFIWVS 744
               |.||.....:||....|....|:...|.:|....||                  ||..    
  Rat   310 ITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLG------------------LFPV---- 352

  Fly   745 AILMLLLAVRLKWIIWDISESFSLRMAITIFTVILIYSVGQVNVFTCVSDHPCSGNGTTSFQNDS 809
                         ::.:||....|.::...|..:.......:|:.|...|    ||..|:..::.
  Rat   353 -------------LLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLD----GNVLTALPDEL 400

  Fly   810 HRKCSLPQYVSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIE------LSHQNIFECYD 868
            .   :|.|..||..:|     :.|.::|.:.:.|.:|....:.|..:|      |:..|..:..|
  Rat   401 G---NLQQLTSLGISF-----NNFSQIPEVLEKLTMLDKVVMAGNRLEILNLGVLTRMNHVKHVD 457

  Fly   869 NRV------------------------NASIPLHLISLARIAIF------MIAILVHG----RLV 899
            .|:                        |....|.|.||..:...      :..:.:.|    .|.
  Rat   458 LRMNHLKTVIIENLEGNKHITHMDLRDNQLTDLDLSSLCSLEQLHCERNQLRELTLSGFSLRNLY 522

  Fly   900 EGTARL---------DFLWQLQASQ-----------EKKEMDVLQ-------ESNKRIL------ 931
            ....:|         ..|..|:.|:           |.|::::|.       |...|||      
  Rat   523 ANWNKLTAVNVYPVPSLLTSLELSRNLLECIPDWACEAKKLEILDISYNLLTEVPMRILSSLSLR 587

  Fly   932 -----HN---LLPA---HVAAHFLDAQFRNNMELYHQSYAK---VGVIFASVPNFNEFYTEMDGS 982
                 ||   :|||   |:....||.|......|....::|   :..:.||..:.....:...| 
  Rat   588 KLMVGHNHIHVLPALVEHIPLEVLDVQHNTLSRLPDTLFSKALNLRYLNASANSLESLPSACAG- 651

  Fly   983 DQGLECLRLL---NEIIAD------------------------FD-------ELLKEDRFRGIDK 1013
            ::.|..|:||   |.::.|                        |.       |.|:|....| :|
  Rat   652 EESLSVLQLLYLTNNLLTDQCIPVLVGHPHLRVLHLANNQLQTFPASKLNKLEQLEELNLSG-NK 715

  Fly  1014 IKTVGST------------YMAVVGLIPEYKIQPNDPNSVRRHMTALIEYVKAMRHSLQEINSHS 1066
            :|.:.:|            :...:.:.||....|.            |::|....:.|.||    
  Rat   716 LKAIPTTIANCKRLHTLVAHANNISIFPEILQLPQ------------IQFVDLSCNDLTEI---- 764

  Fly  1067 YNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVAS-------------RMDSTGVPGYSQVT 1118
                          ::...:.|.....|:.|||..|..             ::|...:|    .|
  Rat   765 --------------LIPETLPATLQDLDLTGNTNLVLEHKTLDMFSHITTLKIDQKPLP----TT 811

  Fly  1119 QEVVDSLVGSHFEFRCRGTIKVKGKGDMVTYFLCDSGNKSLN-----GEV-------RNAMSLPQ 1171
            ...|.|...||      |..::.|:.:.    ||.|.....|     |.|       ||. .||:
  Rat   812 DSTVTSTFWSH------GLAEMAGQRNK----LCVSALAMDNFAEGVGAVYGMFDGDRNE-ELPR 865

  Fly  1172 SLHA--PDYYMKVSQFPEN----RVNTDTYSKKENGHLYAGNGVEEQQLLLQHQHKQHDPLP--- 1227
            .|..  .|..::..|...:    ..||...|.::.|  .||..:....||...:....||..   
  Rat   866 LLQCTMADVLLEEVQHSTSDTVFMANTFLVSHRKLG--MAGQKLGSSALLCYIRPDTADPTSSFS 928

  Fly  1228 -----------------LPAPPPPVHHHLHQ-QQQQRLNSKLQKQPIFMAN--GGL--------- 1263
                             .|.|...|....|. ::.||:  |.||..|...|  .|:         
  Rat   929 LTVANVGTCQAVLCRGGKPVPLSKVFSLEHDPEEAQRV--KDQKAIITEDNKVNGVTCCTRMLGC 991

  Fly  1264 ----------PNIREN-----------GNGHNGEHQQ--QQQQQQQHQQ-------------QQQ 1292
                      |:|...           ||....||..  :.....:|.|             |..
  Rat   992 TYLYPWILPKPHISSTPLTIQDELLILGNKALWEHLSYLEAVSAVRHVQDPLAAAKKLCTLAQSY 1056

  Fly  1293 QQQQHGGFMV----------------------------AT-------TTPPAA------------ 1310
            ..|.:.|.||                            ||       |||.::            
  Rat  1057 GCQDNVGAMVVYLNIGEEGCTCEMHGLALPGPVGFASTATIKDAPKPTTPSSSSGIASELSSEVS 1121

  Fly  1311 -------VAVPLQPQHHQLQFQ-----HPHQ----HPLPSAVSVPVQHQILLHHQLQLQH----- 1354
                   |......:|:.:..:     .|.:    ||:|||.:...|.........|..:     
  Rat  1122 TSEVSSEVGSTASDEHNTVGLETSLLPRPERRCSLHPVPSAGTFQRQPSCATFSSNQSDNGLDSD 1186

  Fly  1355 --QPVPSVMLREFNI---IENPTSGGRHQQMEQLPPHHGSLDLS-----GMGMG------VGAGV 1403
              |||..|:.....:   ::.....||..:.....|.:.|...|     |:|.|      |.:|:
  Rat  1187 DDQPVEGVITNGSRVEVEVDIHCCRGRESENSPTLPKNSSYPCSEEHARGLGFGIRRQNSVNSGI 1251

  Fly  1404 LGSDCFMMPRRDRERTYVPPLNQHGHHPPHHLHSNLNLNQSQHPPSFTSLGYGQCRESEPLLHAS 1468
            |                              |..|.:..:.|..|| ||..||:      .|...
  Rat  1252 L------------------------------LPVNKDKMELQKSPS-TSCLYGK------KLSNG 1279

  Fly  1469 SVAPVAKIMPM----QHAPKYEPPRYTSPHTMLSQQHQ-----------QQQQQQHQHQQPQSQS 1518
            |:.|:...:.:    ..|||.:...:.:| |.|..:.|           ::|.:|||..:|:.:.
  Rat  1280 SIVPLEDSLNLIEVATEAPKRKTGYFAAP-TQLEPEDQFVVPRDLEDEVKEQMKQHQESRPEPEP 1343

  Fly  1519 AQDQQTHPAQD 1529
            .::.:|.|.|:
  Rat  1344 REEDRTEPLQE 1354

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rutNP_511156.2 AC_N <17..255 CDD:292831
CYCc 230..425 CDD:214485 6/42 (14%)
Guanylate_cyc 266..438 CDD:278633 12/55 (22%)
DUF1053 624..696 CDD:283888 16/82 (20%)
SLC5-6-like_sbd <742..>893 CDD:294310 30/186 (16%)
CYCc 924..1134 CDD:214485 53/295 (18%)
Guanylate_cyc 954..1151 CDD:278633 42/258 (16%)
Phlpp2NP_001102601.2 RA_PHLPP2 66..178 CDD:340761 29/136 (21%)
PH_PHLPP-like 185..279 CDD:270131 17/135 (13%)
PLN00113 284..>762 CDD:215061 95/538 (18%)
leucine-rich repeat 289..309 CDD:275380 3/19 (16%)
leucine-rich repeat 310..336 CDD:275380 7/25 (28%)
leucine-rich repeat 337..359 CDD:275380 7/56 (13%)
leucine-rich repeat 360..382 CDD:275380 2/21 (10%)
leucine-rich repeat 383..405 CDD:275380 6/28 (21%)
leucine-rich repeat 406..428 CDD:275380 6/26 (23%)
leucine-rich repeat 429..452 CDD:275380 4/22 (18%)
leucine-rich repeat 453..476 CDD:275380 2/22 (9%)
leucine-rich repeat 477..497 CDD:275380 5/19 (26%)
leucine-rich repeat 498..517 CDD:275380 1/18 (6%)
leucine-rich repeat 518..539 CDD:275380 2/20 (10%)
leucine-rich repeat 540..562 CDD:275380 4/21 (19%)
leucine-rich repeat 563..584 CDD:275380 5/20 (25%)
leucine-rich repeat 586..607 CDD:275380 6/20 (30%)
leucine-rich repeat 608..631 CDD:275380 5/22 (23%)
leucine-rich repeat 632..681 CDD:275380 9/49 (18%)
leucine-rich repeat 682..705 CDD:275380 1/22 (5%)
leucine-rich repeat 706..728 CDD:275380 6/22 (27%)
leucine-rich repeat 751..772 CDD:275380 5/38 (13%)
PP2Cc 820..1069 CDD:238083 52/263 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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