DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rut and NPR3

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_001191304.1	Gene:	NPR3 / 4883	HGNCID:	7945	Length:	541	Species:	Homo sapiens

Alignment Length:	691	Identity:	119/691 - (17%)
Similarity:	211/691 - (30%)	Gaps:	246/691 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   514 LGGGVSVGG-GGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKI---------------LH 562
            |.||...|| ||||||.|:..|              :..|:.:..|||               |.
Human    20 LAGGTGGGGVGGGGGGAGIGGG--------------RQEREALPPQKIEVLVLLPQDDSYLFSLT 70

  Fly   563 ATPPPHGMGYGSVVGSGGG-------------VDSGISGGGGCVS----GGIAGGGGVQVTVGTN 610
            ...|.......||.|:|.|             .:....|.....|    ...|.|....:.:|..
Human    71 RVRPAIEYALRSVEGNGTGRRLLPPGTRFQVAYEDSDCGNRALFSLVDRVAAARGAKPDLILGPV 135

  Fly   611 PNSTASTISRIHRH---------------NHKNNKSQ--SKVADKFKRPFRKRHSVAAHHQPTNR 658
            ....|:.::|:..|               .||:::..  ::||..:.:......::..||
Human   136 CEYAAAPVARLASHWDLPMLSAGALAAGFQHKDSEYSHLTRVAPAYAKMGEMMLALFRHH----- 195

  Fly   659 VNRFLSQAINARSVDCDKSEHVDRLTLRFRQSDMEREYHKDFDLGFTTAMGCSLLLLILGAALQV 723
                                |..|..|.:....:||..       :.|..|...:....|....:
Human   196 --------------------HWSRAALVYSDDKLERNC-------YFTLEGVHEVFQEEGLHTSI 233

  Fly   724 TALPRTLILLLLFLFAFIWVSAILMLLLAVRLKWIIWDISESFSLRMAITIFTVILI-------- 780
            .:...|..|.|..:...|..|..::::.|                 .:.||.:::|:
Human   234 YSFDETKDLDLEDIVRNIQASERVVIMCA-----------------SSDTIRSIMLVAHRHGMTS 281

  Fly   781 --YSVGQVNVFTCVSDHPCSGNGTTSFQNDSHRKCSLPQYVSLSAAFAFLSVS-VFLRLPIIFKS 842
              |:...:.:|...|    .|:|:.. :.|.|...:...|.||.......:|. .|.:..:..||
Human   282 GDYAFFNIELFNSSS----YGDGSWK-RGDKHDFEAKQAYSSLQTVTLLRTVKPEFEKFSMEVKS 341

  Fly   843 LLV---LGMGTIYGLFIELSHQNIFECYDNRVNASIPLHLISLARIAIFMIAILVHGRLVEGTAR 904
            .:.   |.|.....:|:|..|.            :|.|::::|..:
Human   342 SVEKQGLNMEDYVNMFVEGFHD------------AILLYVLALHEV------------------- 375

  Fly   905 LDFLWQLQASQEKKE-MDVLQESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFAS 968
                  |:|...||: ..::|::..|.... :...|:   :||.        ...|....||
Human   376 ------LRAGYSKKDGGKIIQQTWNRTFEG-IAGQVS---IDAN--------GDRYGDFSVI--- 419

  Fly   969 VPNFNEFYTEMDGSDQGLECLRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEYKI 1033
                  ..|:::...|         |:|.|:  ..||.||.....:|
Human   420 ------AMTDVEAGTQ---------EVIGDY--FGKEGRFEMRPNVK------------------ 449

  Fly  1034 QPNDPNSVRRHMTALIEYVKAMRHSLQEINSHSYNNFMLRVGINIGPVVAGVIGA---------R 1089
            .|..|..:|.....::|:..         :|...::..|......|.||..::||         |
Human   450 YPWGPLKLRIDENRIVEHTN---------SSPCKSSGGLEESAVTGIVVGALLGAGLLMAFYFFR 505

  Fly  1090 KPQYDIWGNTVNVASRMDSTGVPGYSQVTQEVVDSLVGSHF 1130
            | :|.|   |:...::.:.:.:..:    :|:.:..:.|||
Human   506 K-KYRI---TIERRTQQEESNLGKH----RELREDSIRSHF 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831
		CYCc	230..425	CDD:214485
		Guanylate_cyc	266..438	CDD:278633
		DUF1053	624..696	CDD:283888	12/88 (14%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	27/164 (16%)
		CYCc	924..1134	CDD:214485	38/216 (18%)
		Guanylate_cyc	954..1151	CDD:278633	33/186 (18%)
NPR3	NP_001191304.1	PBP1_NPR_C_like	54..446	CDD:107381	81/514 (16%)
		ANF_receptor	71..422	CDD:279440	71/462 (15%)
		TM_EphA1	476..507	CDD:214014	8/31 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900