DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rut and Adcy1

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_033752.1	Gene:	Adcy1 / 432530	MGIID:	99677	Length:	1118	Species:	Mus musculus

Alignment Length:	1254	Identity:	493/1254 - (39%)
Similarity:	690/1254 - (55%)	Gaps:	232/1254 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 FENDELECLYQRYTLKLQRFSVLGVVALVFVLCGVMAALSL------TFNNAATFHNIFNAIVCG 76
            |...|||.|::.|||:|::.:.|..:|::.:|.|.:|...|      ....|...|.:...:...
Mouse    39 FACPELEALFRGYTLRLEQAATLKALAVLSLLAGALALAELLGAPGPAPGLAKGSHPVHCILFLA 103

  Fly    77 LFAVVLV-LLQCSVIKDHHLPTLCYGILLFTASICVVSM--PTLGSVFPVDTKEVMAEGVWQIVF 138
            ||.|..| .||.|.::......|.:. |.|....|..::  |...|........|..:||||::.
Mouse   104 LFVVTNVRSLQVSQLQQVGQLALFFS-LTFALLCCPFALGGPARSSAGGAMGSTVAEQGVWQLLL 167

  Fly   139 VVFLAYAMMPLQIWEAVAFGIALPSVHISLTVYKIFTDALRYLEYNQLIANIVIFIGVNVAGLVV 203
            |.|::||::|::...|:.||:.:.:.|:.:|.  ....|.|...:..|.||.::|.|||:.|:.|
Mouse   168 VTFVSYALLPVRSLLAIGFGLVVAASHLLVTA--ALVPAKRPRLWRTLGANALLFFGVNMYGVFV 230

  Fly   204 NIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDILSPVAGQFHRIYI 268
            .|:.||:||:.||..||||..||.::|||||.||||:|:||::|||:||.|.|.|....||:|||
Mouse   231 RILTERSQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYI 295

  Fly   269 QKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYYCVSGLP 333
            |:|:|||||||||||||.|:|||:|||||:|||||||:||:||.:|||.|||||||||||||||.
Mouse   296 QRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLT 360

  Fly   334 EPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDVTLA 398
            :|:.|||.|.|||||||||.|.:|.|||:|.||||||:||||||||||||||||:||||||||||
Mouse   361 QPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLA 425

  Fly   399 NHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFFIVPPPHRRK--PLMLN 461
            |.||:.|.||:||:|:.||..|:|:||||.|||.||:::||.|.::||||| |.||||  |.:
Mouse   426 NVMEAAGLPGKVHITKTTLACLNGDYEVEPGHGHERNTFLRTHNIETFFIV-PSHRRKIFPGL-- 487

  Fly   462 TLGVRSAIGSRRKLSFRNVSNVVMQLLHTIK-FSEPVPFSNIATGSFPSAASALGGGVSVGGGGG 525
               :.|.|...:::.|:.|..:::||:|..| |...:||||:
Mouse   488 ---ILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNV----------------------- 526

  Fly   526 GGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYGSVVGSGGGVDSGISGGG 590
                     .|||         :...|:.:|
Mouse   527 ---------MTCE---------DDDKRRALR---------------------------------- 539

  Fly   591 GCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRHNHKNNKSQSKVADKFKRPFRKRHSVAAHHQP 655
                                   |||...| :|.:...|                    ..:..|
Mouse   540 -----------------------TASEKLR-NRSSFSTN--------------------VVYTTP 560

  Fly   656 TNRVNRFLSQAINARSVDCDKSEHVDRLTLRFRQSDMEREYHKDFDLGFTTAMGCSLLLLILGAA 720
            ..||||::|:.:.||..:.:.:: ::..||:::..:.|::||:..|..||:|:..:|:|..|...
Mouse   561 GTRVNRYISRLLEARQTELEMAD-LNFFTLKYKHVEREQKYHQLQDEYFTSAVVLALILAALFGL 624

  Fly   721 LQVTALPRTLILLLLFLFAFIWVSAILMLLLAVRLKWIIWDISESFSLRMAITIFTVILIYSVGQ 785
            :.:..:|:::.:|||.:|:..::.|..:.|...|::.....:  :..:|.|:.:|.|:|||||.|
Mouse   625 IYLLVIPQSVAVLLLLVFSICFLVACTLYLHITRVQCFPGCL--TIQIRTALCVFIVVLIYSVAQ 687

  Fly   786 VNVFTCVSDHPCSGNGTTSFQNDSH--------RKCSLPQYVSLSAAFAF-------LSVSVFLR 835
            ..|..|:.       ...|.|::|.        |:..||.....||..|.       |.:::|||
Mouse   688 GCVVGCLP-------WAWSSQSNSSLVVLAAGGRRTVLPALPCESAHHALLCCLVGTLPLAIFLR 745

  Fly   836 LPIIFKSLLVLGMGTIYGLFIELSHQNIF-------ECYDNRVNASIPLHLISLARIAIFMIAIL 893
            :..:.|.:|:.|:.|.|.|.:|||.....       ..|:            .:..|.:|...:.
Mouse   746 VSSLPKMILLSGLTTSYILVLELSGYTKVGGGALSGRSYE------------PIMAILLFSCTLA 798

  Fly   894 VHGRLVEGTARLDFLWQLQASQEKKEMDVLQESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQS 958
            :|.|.|:...|||:||..||.:|:.:|:.::..|||||.||||||||.|||.:..| ||:||:||
Mouse   799 LHARQVDVRLRLDYLWAAQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLMSNPR-NMDLYYQS 862

  Fly   959 YAKVGVIFASVPNFNEFYTEMDGSDQGLECLRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMA 1023
            |::|||:|||:||||:||.|:||::.|:||||||||||||||||:.:|.::.::||||:||||||
Mouse   863 YSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMDKDFYKDLEKIKTIGSTYMA 927

  Fly  1024 VVGLIPEYKIQPNDPNSVRRHMTALIEYVKAMRHSLQEINSHSYNNFMLRVGINIGPVVAGVIGA 1088
            .|||.|....:..  .|:..|:..|.::...|...|.|||..|||:|:||||||:||||||||||
Mouse   928 AVGLAPTAGTRAK--KSISSHLCTLADFAIDMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGA 990

  Fly  1089 RKPQYDIWGNTVNVASRMDSTGVPGYSQVTQEVVDSLVGSHFEFRCRGTIKVKGKGDMVTYFL-- 1151
            |:|||||||||||||||||||||.|..|||:||...|....::|.|||.:.|||||:|:||||
Mouse   991 RRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLKRCSYQFVCRGKVSVKGKGEMLTYFLEG 1055

  Fly  1152 CDSGNKSLNGEVRNAMSLPQSLHAPDYYMKVSQFPENRVNTDTYSKKENGHLYAGNGVEEQQLLL 1216
            ...||.|               |...:.::....|..|                |.|
Mouse  1056 RTDGNSS---------------HGRTFRLERRMCPYGR----------------GGG-------- 1081

  Fly  1217 QHQHKQHDPLPLPAPPPPV 1235
               ..:..|| .||..|||
Mouse  1082 ---QARRPPL-CPAAGPPV 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	86/245 (35%)
		CYCc	230..425	CDD:214485	143/194 (74%)
		Guanylate_cyc	266..438	CDD:278633	130/171 (76%)
		DUF1053	624..696	CDD:283888	12/71 (17%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	40/172 (23%)
		CYCc	924..1134	CDD:214485	129/209 (62%)
		Guanylate_cyc	954..1151	CDD:278633	121/196 (62%)
Adcy1	NP_033752.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		AC_N	<158..291	CDD:292831	58/134 (43%)
		CYCc	257..452	CDD:214485	143/194 (74%)
		Guanylate_cyc	293..475	CDD:278633	135/181 (75%)
		Interaction with calmodulin. /evidence=ECO:0000250	492..519		8/26 (31%)
		CYCc	825..1036	CDD:214485	130/213 (61%)
		Guanylate_cyc	858..1055	CDD:278633	123/198 (62%)
		Interaction with calmodulin. /evidence=ECO:0000250	1023..1046		9/22 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1079..1118		9/30 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	266	1.000	Domainoid score	I1869
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41419
Inparanoid	1	1.050	833	1.000	Inparanoid score	I452
Isobase	1	0.950	-	0	Normalized mean entropy	S11743
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006927
OrthoInspector	1	1.000	-	-		oto94488
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	LDO	PTHR45627
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9671
SonicParanoid	1	1.000	-	-		X5020
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.800