DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rut and Ac76E

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster

Alignment Length:	1329	Identity:	428/1329 - (32%)
Similarity:	616/1329 - (46%)	Gaps:	283/1329 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ENDELECLYQRYTLKLQRFSVLGVVALVFVLCGVMAALSLTFNN--AATFHNIFNAIVCGLFAVV 81
            |:..|..||.||..:|::......:....:.|.|...:.:.:..  ..|...:..|::.|   .:
  Fly    63 EDIHLNDLYTRYRQRLRKSLFRSGLLTSLLACVVSIIIGIVYGQHLVQTMLLVLAALISG---SI 124

  Fly    82 LVLLQCSVIKDHHLPTLCYGILLFTASICVVSMPTLGSVFPVDTKEVMAEGVWQIVFVVFLA-YA 145
            |..||...:.......|.:.|:. |.|:..::..|...:.|:.            ::.:||. ::
  Fly   125 LTALQFPAVLSSPAAALAFAIVT-TFSLGTIAAITGDELAPLP------------MYALFLCIHS 176

  Fly   146 MMPLQIWEAVAFGIALPSVHISLTVYKIFTDALRYLEYNQLIANIVIFIGVNVAGLVVNIMMERA 210
            |:|:....:|...:.:.::||   ||:|.|..........|...||:....:|:||...||.:.|
  Fly   177 MLPISWPVSVVLALFMTAIHI---VYRIGTSPDYAPNLPMLFGEIVMLASASVSGLYYRIMSDAA 238

  Fly   211 QRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDIL--------------SPVAG 261
            ..||...||..|..|::::.|.|:.|:|||||:|.::|.::|..|:              |..|.
  Fly   239 HNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSAT 303

  Fly   262 QFHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCY 326
            :||.:::|:|.||:|||||||.||.|||..:|.:||:.||:|||||||:|.:|.|||||||||||
  Fly   304 RFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCY 368

  Fly   327 YCVSGLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVW 391
            |||||||..|..||...|.|||.|||||..|.|||.:.::||:|||||.||||||||||||||||
  Fly   369 YCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVW 433

  Fly   392 SNDVTLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFFIVPP----- 451
            |:||||||||||||..||||:|:.|||.|..::|||.|.|..|.:||.||.|:::.||||
  Fly   434 SDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPAYT 498

  Fly   452 -----------------------------------------------------PHRRKPLMLNT- 462
                                                                 ..:..|..:|:
  Fly   499 YSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPTSINSQ 563

  Fly   463 -LGVRSAIGSRRKLSFRNVSNVVMQLLHTIKFSEPV------------PFSNIA-TGSFPSAAS- 512
             ..:.:.:.|...:|.:.:|....:.......:||:            |.:|.. .||..||||
  Fly   564 EAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHRGSGDSAASE 628

  Fly   513 ----------------ALGG---GVSVGGG-------------GGGGGGGVARGSTCEANSGNVQ 545
                            ::.|   |:|..|.             .....||.|..|...|     :
  Fly   629 SVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVA-----E 688

  Fly   546 VSEKGSRKVIRLQKILHATPPPHGMGYGSVVGSGGGVDSGISGGGGCVSGGIAGGGGVQVTVGTN 610
            ..|:..||:                   ||.|.....|...|      ||....|..:.:..|.:
  Fly   689 APERSRRKL-------------------SVQGLMSFADRRRS------SGAFIEGRKLSIHSGES 728

  Fly   611 PNSTASTISRIHRHNHKNNKSQSKV--------ADKFKRPFRKRHSVAAHHQPTNRVNRFLSQAI 667
            ..|.|..::|        |:..||:        ||   |||            .|.....|.:.|
  Fly   729 FRSHAGHVTR--------NRPSSKMTKYVECWGAD---RPF------------ANIAESKLVKNI 770

  Fly   668 NARSVDCDKSE------------------HVDRLTLRFRQSDMEREYHKDFDLGFTTAMGCSLLL 714
            ...|:...:|.                  .:...|:.:|.:..|..|....|..|...:.|:.:|
  Fly   771 GLASIAMIESNLLPPERKCFNFNFFGPPTELKPFTMWYRNTPREAMYRAQPDTHFRFDLICAFVL 835

  Fly   715 LILGAALQVTALPRTLILLLLFLFAFIWVSAILMLLLAVRLKWIIWDISESFS------------ 767
            .:..|.:|:..:...|.||...|.:|  ||..|.|.|:   ...:.|:..|.:
  Fly   836 FLSLAVVQLIVIELNLALLGSLLASF--VSLALFLYLS---NMSVPDVHASTTERNGPGQVVASS 895

  Fly   768 --LRMAITIFTVILI-----YSVGQVNVFTCVSDHPCS------GNGTTSFQNDSHRKCSL---- 815
              ||:|:.:...|||     :||....|...||..|.|      .|.::.|.|.:.....|
  Fly   896 RYLRLAMFVVVNILISSCAVFSVINYTVPDGVSKEPSSNQTILESNFSSVFVNSTLEDVQLWEID 960

  Fly   816 ------PQY-----VSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQNIFECY-D 868
                  |.:     :||:|..|||.....|:|  |...:.|:...|:.|      :.::||.| |
  Fly   961 YAIPIAPVFLYCCAISLAAISAFLRSGFILKL--IAMLVAVIAQVTVLG------YSDLFEMYND 1017

  Fly   869 NRVNASIPLHLISLARIAIFMIAILVHGRLVEGTARLDFLWQLQASQEKKEMDVLQESNKRILHN 933
            ..:...:||.:.....:.:.::.:....|..|..||.||||:.:...|::|::.::..||.:|.|
  Fly  1018 ANITHGLPLEIKGFLLLLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLEN 1082

  Fly   934 LLPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGLECLRLLNEIIAD 998
            :||||||.|||  ....:.||||:||:.|.|:|||:||:.|||.|.|.:.|||||||||||||.|
  Fly  1083 ILPAHVATHFL--HLERSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICD 1145

  Fly   999 FDELLKEDRFRGIDKIKTVGSTYMAVVGLIP------EYKIQPNDPNSVRRHMTALIEYVKAMRH 1057
            ||:||.:.:|.||:||||:.||||...||.|      ..:...::..:...::..|:|:..|:..
  Fly  1146 FDKLLLKPKFSGIEKIKTIASTYMCASGLRPGKEDGATSRSFADEKRTEEHNVVILVEFAIALMS 1210

  Fly  1058 SLQEINSHSYNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYSQVTQEVV 1122
            .|..||..|:..|.||:|:|.|||:||||||:|||||||.|||||||||||.||.|..|.|:...
  Fly  1211 ILDSINRESFQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTA 1275

  Fly  1123 DSLVGSHFEFRCRGTIKVKGKGDMVTYFL 1151
            ..|:.:.:|..|||...|||||::||||:
  Fly  1276 KILMTAGYECECRGLTYVKGKGNLVTYFV 1304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	58/238 (24%)
		CYCc	230..425	CDD:214485	125/208 (60%)
		Guanylate_cyc	266..438	CDD:278633	115/171 (67%)
		DUF1053	624..696	CDD:283888	16/97 (16%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	43/191 (23%)
		CYCc	924..1134	CDD:214485	109/215 (51%)
		Guanylate_cyc	954..1151	CDD:278633	106/202 (52%)
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	58/240 (24%)
		CYCc	259..467	CDD:214485	125/207 (60%)
		Guanylate_cyc	311..469	CDD:278633	110/157 (70%)
		BASP1	510..667	CDD:283191	19/156 (12%)
		CYCc	1079..1283	CDD:214485	106/205 (52%)
		Guanylate_cyc	1101..1305	CDD:278633	107/204 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	205	1.000	Domainoid score	I1709
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D57794at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	P	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.820