DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rut and CG32305

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster

Alignment Length:	1324	Identity:	316/1324 - (23%)
Similarity:	529/1324 - (39%)	Gaps:	369/1324 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 CGVMAALSLTFNNAATFHNIFNAIVCGLFAVVLVLLQCSVIKDHHLPTLC--YGILLFTASICVV 112
            |..:..|:|..|......::      .|..|..|:|..:::||..|.|:.  :.::||:..|.::
  Fly    42 CSRLRELALMSNVVQIIWHV------ELLMVAHVILLLALVKDIILVTMVPYFAVMLFSPFIMLL 100

  Fly   113 SMP-TLGSVFPVDTKEVMAEGVWQIVFVVFLAYAMMPLQIWEAVAFGIALPSV----HISL-TVY 171
            ||. .:|.:    |..:::   |  :..:||....:...:...:..|.|.|:|    |:.| :||
  Fly   101 SMQNNVGMI----TNTLIS---W--LMALFLTSMDLVSDLLGTIYSGAAYPTVPCYDHVVLVSVY 156

  Fly   172 K---------------------IFTDALRYLEYNQ------LIANIVIFI-GVNVAGLVVNIMME 208
            .                     |:.....|::|..      |:|:..|:: .:|:......|:.:
  Fly   157 MTLPIAFYQGSSVYVLGMVVSIIYIGYAFYMQYLNDQVSFYLLASYAIYLFTLNLIFSFFTIIRD 221

  Fly   209 RAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDILSPVAGQ----------F 263
            ...||..|.....:...:..|...:|...||.|:||:.:...::.:|.|.:..|          .
  Fly   222 YGLRRAILSRYQLVYQNIVYQLVMKKENGLLESILPRKMIRTLQEEICSRIEDQDKNFTPSKAGL 286

  Fly   264 HRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYYC 328
            .:::::.:.|||||.||:|.:|.|::...|.:||.:|::||..||..|:.|..:|||.|||.|.|
  Fly   287 RKLFLEPYPNVSILVADMVNYTHLTTTLEAPQLVEILHDLFVNFDLAANRNRAMRIKFLGDSYNC 351

  Fly   329 VSGLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSN 393
            |:|:|.....||.|.|:..|:||.....|....::.:|:|:|:|:|.|..|::|..|||||:||.
  Fly   352 VAGIPNYFPAHASCCVDQALEMIHITQGVSSRRELDINLRIGVHSGEVFAGIIGHTKWQFDIWSK 416

  Fly   394 DVTLANHMESGGEPGRVHVTRATLDSLSGEYEVEAG-HGDERSSYLRDHGVDTFFIVPPPHRRKP 457
            ||.:.|.:||.|.||.|||::.||..|...|....| ...:....|:..|:.||.
  Fly   417 DVDITNRLESSGLPGLVHVSQRTLSMLDEHYIFREGTEAAKNDPILQQAGIRTFL---------- 471

  Fly   458 LMLNTLGVRSAIGSRRKLSFRNVSNVVMQLLHTIKFSEPVPFSN-IATGSFPSAASALGGGVSVG 521
                                  |||.:...:      ||....: :::.|..|...:.||...
  Fly   472 ----------------------VSNRLPDAV------EPGELDDELSSASINSCRLSYGGYYE-- 506

  Fly   522 GGGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYGSVVGSGGGVDSGI 586
                                   ::..|..|::::                        .||
  Fly   507 -----------------------EIQIKAQREIMK------------------------EVD--- 521

  Fly   587 SGGGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRHNHKNNKSQSKVADKFKRPFRKRHSVAA 651
                             |:.||             |........|..|     |:.|.:.:..
  Fly   522 -----------------QMAVG-------------HCFIEWRRSSSMK-----KQDFNEEYLF-- 549

  Fly   652 HHQPTNRVNRFLSQAINARSVDCDKSEHVDRLTLRFRQSDMEREYHK--DFDLGFTTAMGCSLLL 714
                :|:::..|..                     ||....|.|:|.  |..:.:|       :|
  Fly   550 ----SNQIHLVLGV---------------------FRSWKREWEFHNLPDLMIKYT-------ML 582

  Fly   715 LILGAALQVTAL--------PRTLILLLLFLFAFIWVSAILMLLLA----VRLKW---------- 757
            |:|.|.|.:.::        |..|:||.:.|.      .:::.:||    :||:|
  Fly   583 LVLCAGLAIMSINLIEEATYPDILVLLGILLI------LLILCILAGYKKLRLQWKKLTPMSQPS 641

  Fly   758 ---------IIWDISESFSLRMAITIFTVILIYSVGQVNVFTC-VSDHPCSGNGTTSFQNDSHRK 812
                     |...|.:|..:|:.:|:..::|:|.:....||:| |:....|......:...|:.:
  Fly   642 CFLSRWLLRISERIEDSLFVRIPLTMVVLLLLYVMSSQAVFSCDVAKLELSIIEAHLYNEKSYAE 706

  Fly   813 CSLPQYVSLSAAFAFLSVSVFLRLPIIFK---SLLVLG--MGTI---YGLFIELSHQNIFECYDN 869
            |..|..|:.........:.|....|::.|   .||:||  :||:   ||...|.|     |..|.
  Fly   707 CFGPWTVTYCVVIVISLLFVVPGCPLVIKILAGLLILGLHLGTVHLYYGFAFERS-----ETTDL 766

  Fly   870 RVNASIPLHLISLARIAIFMIAILVHGRLVEGTARLDFLWQLQASQEKKEMDVLQESNKRILHNL 934
            .:.:.. .|...|  :|:|::.:| ..|.|....:.::..::...:..::.|....|.|.|:.|:
  Fly   767 GLKSDY-AHTWYL--VALFIVLVL-RERHVNYLRKFNYFMRVCYEEAHQQTDEKLRSIKIIMANI 827

  Fly   935 LPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGLECLRLLNEIIADF 999
            ||.|||..:  ...|.:.:||:::::||.|:|||:.|||   .:..|       ||:|:|||..|
  Fly   828 LPTHVAQVY--KVRRPHDQLYYENFSKVAVMFASIENFN---ADTAG-------LRILHEIICCF 880

  Fly  1000 DELLKEDRFR-GIDKIKTVGSTYMAVVGL----IPEYKI-----QPNDPNSVRRHMTAL------ 1048
            |:||.:.:.| .|:|||.:|.|||...||    ..::.|     ||...:.:||..:.|
  Fly   881 DDLLVDYQTRYKIEKIKVMGWTYMVACGLETDHYTDFSIDIPVKQPEADSEIRRGSSVLTVHFGS 945

  Fly  1049 --------------------------IEYVKAMRHSLQEINSH----SYNNFM---LRVGINIGP 1080
                                      .|:...:...:.:|..:    .|:.|:   |::||:.|.
  Fly   946 TEDDEMSGDNVSQPYAQVQDVAVLVMTEFALDLLRIMHDIRYNYVFSEYDTFLTGSLKIGISHGS 1010

  Fly  1081 VVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYSQVTQEVVDSLVGSHFEFRC--RGTIKVKGK 1143
            |:|||:|..||.|||||:|||:||||.|||:....|||:.....|  ..|..||  ||..:|||.
  Fly  1011 VMAGVVGLSKPHYDIWGHTVNMASRMSSTGLLDNIQVTRHTAKVL--RQFNIRCNYRGHTEVKGV 1073

  Fly  1144 GDMVTYFLC----------DSGNKSLNGE---VRNAMSL-------PQSLHAPDYYMKVSQFPEN 1188
            |.:.||.:.          |..:.|:...   |.:.:||       |......|......:..||
  Fly  1074 GKVPTYLVVVDPDLTFQDHDQVSMSMKDSKSWVIDTLSLSFTPSFVPPKSSTSDEEEAEGELEEN 1138

  Fly  1189 -----RVNTDTYSKKENGHLYAGN 1207
                 .:....:.:::.|...|||
  Fly  1139 VSEGDELEVSIHERQKGGIFLAGN 1162

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	48/240 (20%)
		CYCc	230..425	CDD:214485	77/204 (38%)
		Guanylate_cyc	266..438	CDD:278633	70/172 (41%)
		DUF1053	624..696	CDD:283888	9/71 (13%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	40/182 (22%)
		CYCc	924..1134	CDD:214485	84/258 (33%)
		Guanylate_cyc	954..1151	CDD:278633	84/247 (34%)
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	77/197 (39%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	68/152 (45%)
		CYCc	814..1056	CDD:214485	84/255 (33%)
		Nucleotidyl_cyc_III	845..1081	CDD:299850	84/247 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D57794at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920