DRSC/TRiP Functional Genomics Resources

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Protein Alignment rut and GUCY2D

DIOPT Version :9

Sequence 1:NP_511156.2 Gene:rut / 32406 FlyBaseID:FBgn0003301 Length:2248 Species:Drosophila melanogaster
Sequence 2:NP_000171.1 Gene:GUCY2D / 3000 HGNCID:4689 Length:1103 Species:Homo sapiens


Alignment Length:337 Identity:93/337 - (27%)
Similarity:156/337 - (46%) Gaps:81/337 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   162 PSVHISLTVYK---------IFTDALRYLEYNQLIANIVIFIGVNVAGLVVNIMMERAQRRTFLD 217
            ||:..:..::|         |....||.||  |..:|:            .:::.||.:      
Human   796 PSMDHTFDLFKNINKGRKTNIIDSMLRMLE--QYSSNL------------EDLIRERTE------ 840

  Fly   218 TRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDILSPVAGQFHRIYIQKHENVSILFADIV 282
                     |::.|.:|.:|||..:||..||..:|..  :||..::       .|.|::.|:|||
Human   841 ---------ELELEKQKTDRLLTQMLPPSVAEALKTG--TPVEPEY-------FEQVTLYFSDIV 887

  Fly   283 GFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYYCVSGLPEPR-KDHAKCAVEM 346
            |||.:|:.....|:|.|||:|:..||.:...:...:::.:||.|...||||:.. :.||.....|
Human   888 GFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANM 952

  Fly   347 GLDMIDAIAT--VVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDVTLANHMESGGEPGR 409
            .||::.|:.|  :....:|.:.:|:|:|:|..:.||:||...::.::.:.|..|:.|||.|.|.|
Human   953 SLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYR 1017

  Fly   410 VHVTRAT---LDSLSGEYEVE-------AGHGDERSSYL--------------------RDHGVD 444
            :||..:|   |.:|...|:||       .|.|.|.:.:|                    .:||: 
Human  1018 IHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVGRRGFNKPIPKPPDLQPGSSNHGI- 1081

  Fly   445 TFFIVPPPHRRK 456
            :...:||..|||
Human  1082 SLQEIPPERRRK 1093

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rutNP_511156.2 AC_N <17..255 CDD:292831 23/101 (23%)
CYCc 230..425 CDD:214485 66/200 (33%)
Guanylate_cyc 266..438 CDD:278633 60/184 (33%)
DUF1053 624..696 CDD:283888
SLC5-6-like_sbd <742..>893 CDD:294310
CYCc 924..1134 CDD:214485
Guanylate_cyc 954..1151 CDD:278633
GUCY2DNP_000171.1 PBP1_sensory_GC_DEF-like 55..431 CDD:380594
PK_GC-2D 536..811 CDD:270945 3/14 (21%)
HNOBA <820..865 CDD:369471 18/73 (25%)
CYCc 846..1036 CDD:214485 65/198 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1065..1103 7/30 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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