DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rut and GUCY1B1

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	XP_011530203.1	Gene:	GUCY1B1 / 2983	HGNCID:	4687	Length:	662	Species:	Homo sapiens

Alignment Length:	189	Identity:	69/189 - (36%)
Similarity:	109/189 - (57%)	Gaps:	17/189 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 LERLLLSVLPQHVAMQMKNDILSPVAGQFHRIYIQKHENVSILFADIVGFTVLSSQCS----AQE 295
            |.|||.||||..||.::::.  .||..       ::::||:|||:.||||....|:.:    |.:
Human   433 LNRLLYSVLPPSVANELRHK--RPVPA-------KRYDNVTILFSGIVGFNAFCSKHASGEGAMK 488

  Fly   296 LVRLLNELFGRFDQLAHDN---HCLRIKILGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIATV 357
            :|.|||:|:.|||.|....   ...:::.:||.|..|||||||...||:....:.|||:: ||..
Human   489 IVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMME-IAGQ 552

  Fly   358 VEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDVTLANHMESGGEPGRVHVTRAT 416
            |:.....:.:.:|||||.|:.||:|.|..::.::.|.|.|.:..|:.||.|:::|:..|
Human   553 VQVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYT 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	10/19 (53%)
		CYCc	230..425	CDD:214485	69/189 (37%)
		Guanylate_cyc	266..438	CDD:278633	57/158 (36%)
		DUF1053	624..696	CDD:283888
		SLC5-6-like_sbd	<742..>893	CDD:294310
		CYCc	924..1134	CDD:214485
		Guanylate_cyc	954..1151	CDD:278633
GUCY1B1	XP_011530203.1	HNOB	2..166	CDD:311572
		HNOBA	207..449	CDD:311573	10/15 (67%)
		Guanylate_cyc	455..648	CDD:306677	58/165 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810