DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rut and Adcy6

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_001257714.1	Gene:	Adcy6 / 25289	RGDID:	2035	Length:	1180	Species:	Rattus norvegicus

Alignment Length:	1203	Identity:	456/1203 - (37%)
Similarity:	637/1203 - (52%)	Gaps:	238/1203 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 RFENDELECLYQRYTLKLQRFSVLGVVALVFVLCGVMAALSLTFNNAATFHNIFNAIVCGLFAVV 81
            :|.:.:||.|||||..::.:.|:..::|::.:|..|:    |||:.|.....          ...
  Rat   142 QFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLMAVL----LTFHAAPALPQ----------PAY 192

  Fly    82 LVLLQCSVIKDHHLPTLCYGILLFTASICVVSMPTLGSVFPVDTKEVMA-------EGVWQIVFV 139
            :.||.|:.:....|..:|........|:.|||...||.:..|.....:|       .|:|..||.
  Rat   193 VALLTCASVLFVVLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAANPRSPSAGLWCPVFF 257

  Fly   140 VFLAYAMMPLQIWEAVAFGIALPSVHISLTVYKIFTDALRYLEYNQLIANIVIFIGVNVAGLVVN 204
            |::.|.::|:::..||..|:.|.::|:.|..:....|...   :.||.||:|:|:..|..|:..:
  Rat   258 VYITYTLLPIRMRAAVLSGLGLSTLHLILAWHLNNGDPFL---WKQLGANVVLFLCTNAIGVCTH 319

  Fly   205 IMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDILSPVAG-QFHRIYI 268
            ...|.:||:.|.:||..|.:||.:|.||.:.||||||||||||||:||.||.:.... .||:|||
  Rat   320 YPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYI 384

  Fly   269 QKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYYCVSGLP 333
            |||:|||||||||.|||.|:|||:|||||..|||||.|||:||.:||||||||||||||||||||
  Rat   385 QKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLP 449

  Fly   334 EPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDVTLA 398
            |.|.|||.|.||||:|||:||:.|.|.|.|.:|||||||:|||.|||||||||||||||||||||
  Rat   450 EARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLA 514

  Fly   399 NHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFFIVPPPHRRKPLMLNTL 463
            ||||:||..||:|:|||||..|:|:||||.|.|.||::||::..::||.|:....:||
  Rat   515 NHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQCIETFLILGASQKRK------- 572

  Fly   464 GVRSAIGSRRKLSFRNVSNVVMQLLHTIKFSEPVPFSNIATGSFPSAASALGGGVSVGGGGGGGG 528

  Rat   573 ----------------------------------------------------------------- 572

  Fly   529 GGVARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYGSVVGSGGGVDSGISGGGGCV 593
                              .||.  .:::||:
  Rat   573 ------------------EEKA--MLVKLQR---------------------------------- 583

  Fly   594 SGGIAGGGGVQVTVGTNPNSTASTISR------IHRHNHKNNKSQSKVADKFKRPFRKRHSVAAH 652
                           |..||....:.|      ..|........|..:.|..|.....:.::
  Rat   584 ---------------TRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKENRGAQDAL--- 630

  Fly   653 HQPTNRVNRFLSQAINARSVDCDKSEHVDRLTLRFRQSDMEREYHKDFDLGFTTAMGCSLLLLIL 717
             .|.:.|:.||.:||:|||:|..:.:||.|..|.|::.|:|::|.:..|..|...:.|:||:...
  Rat   631 -NPEDEVDEFLGRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCF 694

  Fly   718 GAALQVTALPRTLILLLLFLFAFIWVSAILMLLLAV---------RLKWIIWDISESFSLRMAIT 773
            ...:|....|.:.::|.::...|: :..:.:|:.||         .|:.:...|..|.....|:.
  Rat   695 ICFIQFLVFPHSALILGIYAGIFL-LLLVTVLICAVCSCGSFFPNALQRLSRSIVRSRVHSTAVG 758

  Fly   774 IFTVILIYSVGQVNVFTCVSDHP---CSG---NGTTSFQNDSHRK-------------------C 813
            :|:|:|::.....|:||| |..|   |:.   |.|.|.....|.:                   |
  Rat   759 VFSVLLVFISAIANMFTC-SHTPLRTCAARMLNLTPSDVTACHLRQLNYSLGLEAPLCEGTAPTC 822

  Fly   814 SLPQYVSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELS-HQNIFECYDNRVN----- 872
            |.|:|...|...:.|:.||||.:..|.|.::...:|.||.|.:.|. ...||:.||..::
  Rat   823 SFPEYFVGSVLLSLLASSVFLHISSIGKLVMTFVLGFIYLLLLLLGPPATIFDNYDLLLSVHGLA 887

  Fly   873 --------------ASIPLHLISLARIAIFMIAILVHGRLVEGTARLDFLWQLQASQEKKEMDVL 923
                          ..:.|..::...:.:|.:|:.:|.:.||.||||||||:|||:.||:||:.|
  Rat   888 SSNETFDGLDCPAVGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEEL 952

  Fly   924 QESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGLEC 988
            |..|:|:|||:||..|||||| |:.|.|.|||:||...|.|:|||:.||:|||.|::.:::|:||
  Rat   953 QAYNRRLLHNILPKDVAAHFL-ARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVEC 1016

  Fly   989 LRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEYKIQPNDPNSVRRHMTALIEYVK 1053
            |||||||||||||::.|:|||.::||||:||||||..||......|..     |.|:|||.:|..
  Rat  1017 LRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVG-----RSHITALADYAM 1076

  Fly  1054 AMRHSLQEINSHSYNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYSQVT 1118
            .:...::.||.||:|||.:::|:|:||||||||||||||||||||||||:|||||||||...|||
  Rat  1077 RLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVT 1141

  Fly  1119 QEVVDSLVGSHFEFRCRGTIKVKGKGDMVTYFL 1151
            .::...|....::..|||.:||||||:|.||||
  Rat  1142 TDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFL 1174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	79/244 (32%)
		CYCc	230..425	CDD:214485	145/195 (74%)
		Guanylate_cyc	266..438	CDD:278633	131/171 (77%)
		DUF1053	624..696	CDD:283888	20/71 (28%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	45/204 (22%)
		CYCc	924..1134	CDD:214485	118/209 (56%)
		Guanylate_cyc	954..1151	CDD:278633	112/196 (57%)
Adcy6	NP_001257714.1	AC_N	28..380	CDD:292831	81/254 (32%)
		CYCc	346..541	CDD:214485	145/194 (75%)
		Guanylate_cyc	382..566	CDD:278633	136/183 (74%)
		DUF1053	594..680	CDD:283888	24/89 (27%)
		CYCc	956..1157	CDD:214485	117/206 (57%)
		Guanylate_cyc	982..1176	CDD:278633	114/198 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810