Protein Alignment rut and Adcy6

DIOPT Version :10

• Sequence 1: NP_511156.2
• Gene: rut / 32406
• FlyBaseID: FBgn0003301
• Length: 2248
• Species: Drosophila melanogaster
• Sequence 2: NP_001257714.1
• Gene: Adcy6 / 25289
• RGDID: 2035
• Length: 1180
• Species: Rattus norvegicus
• Alignment Length: 1203
• Identity: 456/1203 - (37%)
• Similarity: 637/1203 - (52%)
• Gaps: 238/1203 - (19%)

  Fly    17 RFENDELECLYQRYTLKLQRFSVLGVVALVFVLCGVMAALSLTFNNAATFHNIFNAIVCGLFAVV 81
            :|.:.:||.|||||..::.:.|:..::|::.:|..|:    |||:.|.....          ...
  Rat   142 QFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLMAVL----LTFHAAPALPQ----------PAY 192

  Fly    82 LVLLQCSVIKDHHLPTLCYGILLFTASICVVSMPTLGSVFPVDTKEVMA-------EGVWQIVFV 139
            :.||.|:.:....|..:|........|:.|||...||.:..|.....:|       .|:|..||.
  Rat   193 VALLTCASVLFVVLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAANPRSPSAGLWCPVFF 257

  Fly   140 VFLAYAMMPLQIWEAVAFGIALPSVHISLTVYKIFTDALRYLEYNQLIANIVIFIGVNVAGLVVN 204
            |::.|.::|:::..||..|:.|.::|:.|..:....|...   :.||.||:|:|:..|..|:..:
  Rat   258 VYITYTLLPIRMRAAVLSGLGLSTLHLILAWHLNNGDPFL---WKQLGANVVLFLCTNAIGVCTH 319

  Fly   205 IMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDILSPVAG-QFHRIYI 268
            ...|.:||:.|.:||..|.:||.:|.||.:.||||||||||||||:||.||.:.... .||:|||
  Rat   320 YPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYI 384

  Fly   269 QKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYYCVSGLP 333
            |||:|||||||||.|||.|:|||:|||||..|||||.|||:||.:||||||||||||||||||||
  Rat   385 QKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLP 449

  Fly   334 EPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDVTLA 398
            |.|.|||.|.||||:|||:||:.|.|.|.|.:|||||||:|||.|||||||||||||||||||||
  Rat   450 EARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLA 514

  Fly   399 NHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFFIVPPPHRRKPLMLNTL 463
            ||||:||..||:|:|||||..|:|:||||.|.|.||::||::..::||.|:....:||
  Rat   515 NHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQCIETFLILGASQKRK------- 572

  Fly   464 GVRSAIGSRRKLSFRNVSNVVMQLLHTIKFSEPVPFSNIATGSFPSAASALGGGVSVGGGGGGGG 528
                                                                             
  Rat   573 ----------------------------------------------------------------- 572

  Fly   529 GGVARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYGSVVGSGGGVDSGISGGGGCV 593
                              .||.  .:::||:
  Rat   573 ------------------EEKA--MLVKLQR---------------------------------- 583

  Fly   594 SGGIAGGGGVQVTVGTNPNSTASTISR------IHRHNHKNNKSQSKVADKFKRPFRKRHSVAAH 652
                           |..||....:.|      ..|........|..:.|..|.....:.::
  Rat   584 ---------------TRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKENRGAQDAL--- 630

  Fly   653 HQPTNRVNRFLSQAINARSVDCDKSEHVDRLTLRFRQSDMEREYHKDFDLGFTTAMGCSLLLLIL 717
             .|.:.|:.||.:||:|||:|..:.:||.|..|.|::.|:|::|.:..|..|...:.|:||:...
  Rat   631 -NPEDEVDEFLGRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCF 694

  Fly   718 GAALQVTALPRTLILLLLFLFAFIWVSAILMLLLAV---------RLKWIIWDISESFSLRMAIT 773
            ...:|....|.:.::|.::...|: :..:.:|:.||         .|:.:...|..|.....|:.
  Rat   695 ICFIQFLVFPHSALILGIYAGIFL-LLLVTVLICAVCSCGSFFPNALQRLSRSIVRSRVHSTAVG 758

  Fly   774 IFTVILIYSVGQVNVFTCVSDHP---CSG---NGTTSFQNDSHRK-------------------C 813
            :|:|:|::.....|:||| |..|   |:.   |.|.|.....|.:                   |
  Rat   759 VFSVLLVFISAIANMFTC-SHTPLRTCAARMLNLTPSDVTACHLRQLNYSLGLEAPLCEGTAPTC 822

  Fly   814 SLPQYVSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELS-HQNIFECYDNRVN----- 872
            |.|:|...|...:.|:.||||.:..|.|.::...:|.||.|.:.|. ...||:.||..::
  Rat   823 SFPEYFVGSVLLSLLASSVFLHISSIGKLVMTFVLGFIYLLLLLLGPPATIFDNYDLLLSVHGLA 887

  Fly   873 --------------ASIPLHLISLARIAIFMIAILVHGRLVEGTARLDFLWQLQASQEKKEMDVL 923
                          ..:.|..::...:.:|.:|:.:|.:.||.||||||||:|||:.||:||:.|
  Rat   888 SSNETFDGLDCPAVGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEEL 952

  Fly   924 QESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGLEC 988
            |..|:|:|||:||..|||||| |:.|.|.|||:||...|.|:|||:.||:|||.|::.:::|:||
  Rat   953 QAYNRRLLHNILPKDVAAHFL-ARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVEC 1016

  Fly   989 LRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEYKIQPNDPNSVRRHMTALIEYVK 1053
            |||||||||||||::.|:|||.::||||:||||||..||......|..     |.|:|||.:|..
  Rat  1017 LRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVG-----RSHITALADYAM 1076

  Fly  1054 AMRHSLQEINSHSYNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYSQVT 1118
            .:...::.||.||:|||.:::|:|:||||||||||||||||||||||||:|||||||||...|||
  Rat  1077 RLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVT 1141

  Fly  1119 QEVVDSLVGSHFEFRCRGTIKVKGKGDMVTYFL 1151
            .::...|....::..|||.:||||||:|.||||
  Rat  1142 TDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFL 1174

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:318454	79/244 (32%)
		Guanylate_cyc	266..428	CDD:425528	126/161 (78%)
		Adcy_cons_dom	624..698	CDD:461877	21/73 (29%)
		AcyC	742..1150	CDD:441717	193/461 (42%)
		Guanylate_cyc	954..1151	CDD:425528	112/196 (57%)
Adcy6	NP_001257714.1	AC_N	28..380	CDD:318454	81/254 (32%)
		Guanylate_cyc	382..566	CDD:425528	136/183 (74%)
		Adcy_cons_dom	594..681	CDD:461877	24/90 (27%)
		Guanylate_cyc	982..1176	CDD:425528	114/198 (58%)