DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rut and Gucy1b2

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	XP_011243363.2	Gene:	Gucy1b2 / 239134	MGIID:	2660873	Length:	829	Species:	Mus musculus

Alignment Length:	461	Identity:	118/461 - (25%)
Similarity:	208/461 - (45%)	Gaps:	79/461 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   802 TTSFQNDSHRKCSLPQYV-SLSAAFAFLSVSVFLR-----LPIIFKSLLVLGM-GTIYGLFIELS 859
            |..|..|.:.....||.. ::|:...|::....|:     :|..:||...|.: |.:  :::|..
Mouse   414 TQKFGLDEYFSIVHPQVTFNISSICKFINSQFILKTRREMMPEAWKSQPTLKLRGQM--IWMESL 476

  Fly   860 HQNIFECYD-----NRVNASIPLHLISLARIAIFMIAILVHGRLVEGTARLDFLWQLQASQEKKE 919
            ...:|.|..     ..:..| .:||..:|........||::.:.:   |.::...||:  ::|:|
Mouse   477 KCMVFMCSPKLRSLQELEES-KMHLSDIAPHDTTRDLILLNQQRL---AEMELSCQLE--KKKEE 535

  Fly   920 MDVL-------QESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYT 977
            :.||       ::..:.:|:.:||.|||     .|.:...::....:....::|:.|..|    |
Mouse   536 LRVLSNHLAIEKKKTETLLYAMLPEHVA-----NQLKEGKKVAAGEFETCTILFSDVVTF----T 591

  Fly   978 EMDGSDQGLECLRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEYKIQPNDPNSVR 1042
            .:..:.:.::.:.:||.:.:.||.|   .....:.|::|:|..||.|.|:          |..|.
Mouse   592 NICAACEPIQIVNMLNSMYSKFDRL---TNIHDVYKVETIGDAYMVVGGV----------PVPVE 643

  Fly  1043 RHMTALIEYVKAMRHSLQEI-NSHSYNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRM 1106
            .|...:..:...||.|.:|: |..:.....:||||:.|||:|||:|.:.|:|.::|:|||.||||
Mouse   644 SHAQRVANFALGMRISAKEVMNPVTGEPIQIRVGIHTGPVLAGVVGDKMPRYCLFGDTVNTASRM 708

  Fly  1107 DSTGVPGYSQVTQEVVDSLVGSHFEFRCRGTIKVKGKGDMVTYFLCDSGNKSLNGEVRNAMSLPQ 1171
            :|.|:|....::.....:|....||...||.|:|||||.|.||||.    ::||......|..|.
Mouse   709 ESHGLPNKVHLSPTAHRALENKGFEIVTRGEIEVKGKGKMTTYFLI----RNLNATEVEIMGRPS 769

  Fly  1172 SLHAPDYYMKVSQFPENRV--------NTDTYSKKENGHLYAGN-----GVEEQQLLLQHQHKQH 1223
            :|...    |.:..|.|:|        |.|.:.::    :|..:     |...:...::.:|
Mouse   770 ALADG----KEASTPRNQVKKPRAVLSNMDHHQQQ----VYNSDPADVLGTASRTASVKGKH--- 823

  Fly  1224 DPLPLP 1229
             |.|||
Mouse   824 -PTPLP 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831
		CYCc	230..425	CDD:214485
		Guanylate_cyc	266..438	CDD:278633
		DUF1053	624..696	CDD:283888
		SLC5-6-like_sbd	<742..>893	CDD:294310	20/102 (20%)
		CYCc	924..1134	CDD:214485	58/210 (28%)
		Guanylate_cyc	954..1151	CDD:278633	62/197 (31%)
Gucy1b2	XP_011243363.2	HNOB	115..276	CDD:400167
		HNOBA	380..566	CDD:400168	35/164 (21%)
		Guanylate_cyc	572..754	CDD:306677	63/198 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810