DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rut and Gucy1a2

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_001028494.1	Gene:	Gucy1a2 / 234889	MGIID:	2660877	Length:	730	Species:	Mus musculus

Alignment Length:	428	Identity:	114/428 - (26%)
Similarity:	190/428 - (44%)	Gaps:	95/428 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 TFNNAATFHNIFNAIVCGLFAVVLVL---LQCSVIKDHHLPTL---CYGIL--LFTASICVVSMP 115
            ||..|..||.:|::.:     |||.|   |:..:..|.|....   |:.|:  :..|:...|.:
Mouse   320 TFCRAFPFHLMFDSNM-----VVLQLGEGLRKQLRYDTHRALKFEDCFEIVSPMINATFDRVLL- 378

  Fly   116 TLGSVFPVDTK---------EVMAEGVWQIVFV------VFLAYAMMPLQIWEAVAFGIALPSVH 165
            .|.:.|.:.||         :.:.|...|::.|      :||....:. ::.|.:..|:.|..:.
Mouse   379 RLSTPFVIRTKPEASGTENEDKVMEIKGQMIHVPESSAILFLGSPCVD-KLDELMGRGLHLSDIP 442

  Fly   166 ISLTVYKIFTDALRYLEYNQLIANIVIFIGVNVAGLVVNIMMERAQRRTFLDTR-NCIASRLE-- 227
            |.        ||.|          .||.:|            |:|:.:..|..| :.:.:.||
Mouse   443 IH--------DATR----------DVILVG------------EQAKAQDGLKKRMDKLKATLERT 477

  Fly   228 ---IQDENEKLERLLLSVLPQHVAMQMKNDILSPVAGQFHRIYIQKHENVSILFADIVGFTVLSS 289
               :::|.:|...||.|:.|..||.|:         .|..::..:|.::|::||:||||||.:.:
Mouse   478 HQALEEEKKKTVDLLYSIFPGDVAQQL---------WQGQQVQARKFDDVTMLFSDIVGFTAICA 533

  Fly   290 QCSAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAI 354
            ||:..:::.:||||:.|||.........:::.:||.|...|||......|||....|.|.|::..
Mouse   534 QCTPMQVISMLNELYTRFDHQCGLLDIYKVETIGDAYCVASGLHRKSLCHAKPIALMALKMMELS 598

  Fly   355 ATVVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDS 419
            ..|:......:.||:|||:|.||.||:|:|..::.::.|:||||:..|||..|.|::|:..|...
Mouse   599 EEVLTPDGKAIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQL 663

  Fly   420 LSGEYEVEAGHGDERSSYLRDHGVDTFFIVPPPHRRKP 457
            |..|                    |:|..:|......|
Mouse   664 LKRE--------------------DSFTFIPRSREELP 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	51/224 (23%)
		CYCc	230..425	CDD:214485	68/194 (35%)
		Guanylate_cyc	266..438	CDD:278633	58/171 (34%)
		DUF1053	624..696	CDD:283888
		SLC5-6-like_sbd	<742..>893	CDD:294310
		CYCc	924..1134	CDD:214485
		Guanylate_cyc	954..1151	CDD:278633
Gucy1a2	NP_001028494.1	HNOB	<157..268	CDD:285002
		HNOBA	314..501	CDD:285003	48/217 (22%)
		CYCc	483..672	CDD:214485	70/217 (32%)
		Guanylate_cyc	512..696	CDD:278633	62/190 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810