DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rut and PHLPP2

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_055835.2	Gene:	PHLPP2 / 23035	HGNCID:	29149	Length:	1323	Species:	Homo sapiens

Alignment Length:	1470	Identity:	267/1470 - (18%)
Similarity:	432/1470 - (29%)	Gaps:	535/1470 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   396 TLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFFIVPPPHRRKPLML 460
            |.::...|......:|:...|:::.:.  |:.||.|.| |.||:.|| |....:.|..|  ||
Human    48 TTSSSSSSSSSSSDLHLVLCTVETPAS--EICAGEGRE-SLYLQLHG-DLVRRLEPTER--PL-- 104

  Fly   461 NTLGVRSAIGSRRKLSFRNVSNVVMQLLHTIKFSEPVPFSNIAT-----------GSFPSAASAL 514
                                 .:|...|..:.|.:||.....||           |..|.....|
Human   105 ---------------------QIVYDYLSRLGFDDPVRIQEEATNPDLGCMIRFYGEKPCHMDRL 148

  Fly   515 GGGVSVGGGGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYGSVVGSG 579
                          ..:..........|..|:.:...|.|:..
Human   149 --------------DRILLSGIYNVRKGKTQLHKWAERLVVLC---------------------- 177

  Fly   580 GGVDSGISGGGGCVSG-----GIAGGGGVQVTVGTNPNSTASTISRIHRHNHK-NNKSQSKVADK 638
             |....:|....|.:|     .:.||                .|..:.|..:. ...|....|..
Human   178 -GTCLIVSSVKDCQTGKMHILPLVGG----------------KIEEVKRRQYSLAFSSAGAQAQT 225

  Fly   639 FKRPFRKRHSVAAHHQPTNRVNRFLSQAINARSVDCDKSEHVDR----------LTLRFRQSDME 693
            :...|   .::|.:.:...:.::.:||.|:...:.|...|.|..          |.||.....:|
Human   226 YHVSF---ETLAEYQRWQRQASKVVSQRISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLE 287

  Fly   694 REYHKDFDLGFTTAMGCSLLLLILGAALQVTALPRTLILLLLFLFAFIWVSAILMLLLAVRLKWI 758
            |....|....|:...|.:|....||                  ||..                 :
Human   288 RPGGLDTLYKFSQLKGLNLSHNKLG------------------LFPI-----------------L 317

  Fly   759 IWDISESFSLRMAITIFTVILIYSVGQVNVFTCVSDHPCSGNGTTSFQNDSHRKCSLPQYVSLSA 823
            :.:||....|.::...|..:.......:|:.|...|    ||..|:...:..   :|.|..||..
Human   318 LCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLD----GNFLTTLPEELG---NLQQLSSLGI 375

  Fly   824 AFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIE------LSHQNIFECYDNRVNASIPLHLISL 882
            :|     :.|.::|.:::.|.:|....:.|..:|      |:..|..:..|.|:|     ||.::
Human   376 SF-----NNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMN-----HLKTM 430

  Fly   883 A------------------RIAIFMIAIL-----VH-GR---------------LVEGTARL--- 905
            .                  |:....::.|     :| ||               |...:.||
Human   431 VIENLEGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSNRLTAV 495

  Fly   906 ------DFLWQLQASQ-----------EKKEMDVLQESNK-------RILHNL------------ 934
                  ..|..|..|:           |.|:::||..|..       |||.:|
Human   496 NVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHV 560

  Fly   935 --LPA---HVAAHFLDAQFRNNMELYHQSYAK---VGVIFASVPNFNEFYTEMDGSDQGLECLRL 991
              ||.   |:....||.|......|....::|   :..:.||..:.....:...| ::.|..|:|
Human   561 QNLPTLVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTG-EESLSMLQL 624

  Fly   992 L---NEIIAD------------------------FD-------ELLKEDRFRGIDKIKTVGST-- 1020
            |   |.::.|                        |.       |.|:|....| :|:||:.:|
Human   625 LYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSG-NKLKTIPTTIA 688

  Fly  1021 ----------YMAVVGLIPEYKIQPNDPNSVRRHMTALIEYVKAMRHSLQEINSHSYNNFMLRVG 1075
                      :...:.:.||....|.            |::|....:.|.||
Human   689 NCKRLHTLVAHSNNISIFPEILQLPQ------------IQFVDLSCNDLTEI------------- 728

  Fly  1076 INIGPVVAGVIGARKPQYDIWGN--------TVNVAS-----RMDSTGVPGYSQVTQEVVDSLVG 1127
                 ::...:.|.....|:.||        |:::.|     ::|...:|    .|...|.|...
Human   729 -----LIPEALPATLQDLDLTGNTNLVLEHKTLDIFSHITTLKIDQKPLP----TTDSTVTSTFW 784

  Fly  1128 SHFEFRCRGTIKVKGKGD--MVTYFLCDSGNKSLNGEV-------RNAMSLPQSLHA--PDYYMK 1181
            ||      |..::.|:.:  .|:....||..:.: |.|       ||. .||:.|..  .|..::
Human   785 SH------GLAEMAGQRNKLCVSALAMDSFAEGV-GAVYGMFDGDRNE-ELPRLLQCTMADVLLE 841

  Fly  1182 VSQFPEN----RVNTDTYSKKENGHLYAGNGVEEQQLLLQHQHKQHDP----------------- 1225
            ..|...|    ..||...|.::.|  .||..:....||...:....||
Human   842 EVQQSTNDTVFMANTFLVSHRKLG--MAGQKLGSSALLCYIRPDTADPASSFSLTVANVGTCQAV 904

  Fly  1226 LPLPAPPPPVH--HHLHQQQQQRLNSKLQKQPIFMAN--GGL-------------------PNIR 1267
            |.....|.|:.  ..|.|..::....|.||..|...|  .|:                   |:|.
Human   905 LCRGGKPVPLSKVFSLEQDPEEAQRVKDQKAIITEDNKVNGVTCCTRMLGCTYLYPWILPKPHIS 969

  Fly  1268 EN-----------GNGHNGEHQQQQQ--QQQQHQQ-------------QQQQQQQHGGFMV---- 1302
            ..           ||....||....:  ...:|.|             |....|.:.|.||
Human   970 STPLTIQDELLILGNKALWEHLSYTEAVNAVRHVQDPLAAAKKLCTLAQSYGCQDNVGAMVVYLN 1034

  Fly  1303 ---------------------ATTTPPAAVAVPLQPQHHQLQFQHPHQHPLPSAVSVPVQHQILL 1346
                                 |:||.......|..|................|.||..|......
Human  1035 IGEEGCTCEMNGLTLPGPVGFASTTTIKDAPKPATPSSSSGIASEFSSEMSTSEVSSEVGSTASD 1099

  Fly  1347 HHQ---LQLQHQPVPSVMLREFNIIENPTSGGRHQQMEQLPPHHGSLDLSGMGMGVGA------- 1401
            .|.   |.....|.|.   |..::...||||     :.|..|...:...:....|:.:
Human  1100 EHNAGGLDTALLPRPE---RRCSLHPTPTSG-----LFQRQPSSATFSSNQSDNGLDSDDDQPVE 1156

  Fly  1402 GVL--GS------DCFMMPRRDRERTYVPPL---------NQH------GHHPPHHLHSNLNLNQ 1443
            ||:  ||      |......||.|.:  |||         .:|      |....:.::|.:.|..
Human  1157 GVITNGSKVEVEVDIHCCRGRDLENS--PPLIESSPTLCSEEHARGSCFGIRRQNSVNSGMLLPM 1219

  Fly  1444 S------QHPPSFTSLGYGQ---------CRESEPLLHASSVAPVAK----IMPMQHAPKYEPPR 1489
            |      |..|| ||..||:         ..:|..|:..::..|..|    ..|.|..|:   .:
Human  1220 SKDRMELQKSPS-TSCLYGKKLSNGSIVPLEDSLNLIEVATEVPKRKTGYFAAPTQMEPE---DQ 1280

  Fly  1490 YTSPHTMLSQQHQQQQQQQHQHQQPQSQSAQDQQTHPAQD 1529
            :..||.:  ::..::|.:|||..:.:.:..::.:|.|.::
Human  1281 FVVPHDL--EEEVKEQMKQHQDSRLEPEPHEEDRTEPPEE 1318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831
		CYCc	230..425	CDD:214485	4/28 (14%)
		Guanylate_cyc	266..438	CDD:278633	10/41 (24%)
		DUF1053	624..696	CDD:283888	15/82 (18%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	29/174 (17%)
		CYCc	924..1134	CDD:214485	52/295 (18%)
		Guanylate_cyc	954..1151	CDD:278633	44/260 (17%)
PHLPP2	NP_055835.2	PH_PHLPP-like	149..243	CDD:270131	16/135 (12%)
		LRR 1	250..271		4/20 (20%)
		leucine-rich repeat	253..273	CDD:275380	3/19 (16%)
		LRR 2	273..296		6/22 (27%)
		leucine-rich repeat	274..300	CDD:275380	7/25 (28%)
		LRR 3	300..321		6/55 (11%)
		leucine-rich repeat	301..323	CDD:275380	7/56 (13%)
		LRR_RI	313..606	CDD:238064	60/326 (18%)
		LRR_8	322..380	CDD:290566	14/69 (20%)
		LRR 4	323..344		2/20 (10%)
		leucine-rich repeat	324..346	CDD:275380	2/21 (10%)
		LRR 5	346..368		6/28 (21%)
		leucine-rich repeat	347..369	CDD:275380	6/28 (21%)
		LRR 6	369..390		6/25 (24%)
		leucine-rich repeat	370..416	CDD:275380	10/50 (20%)
		LRR 7	392..412		3/19 (16%)
		LRR 8	416..439		5/27 (19%)
		leucine-rich repeat	418..440	CDD:275380	5/26 (19%)
		LRR 9	440..460		1/19 (5%)
		leucine-rich repeat	442..461	CDD:275380	2/18 (11%)
		LRR 10	461..480		3/18 (17%)
		leucine-rich repeat	462..481	CDD:275380	3/18 (17%)
		LRR 11	481..502		3/20 (15%)
		leucine-rich repeat	482..503	CDD:275380	3/20 (15%)
		LRR 12	503..524		3/20 (15%)
		leucine-rich repeat	504..526	CDD:275380	4/21 (19%)
		LRR 13	526..547		6/20 (30%)
		leucine-rich repeat	527..549	CDD:275380	6/21 (29%)
		LRR_8	549..606	CDD:290566	10/56 (18%)
		LRR 14	549..570		2/20 (10%)
		leucine-rich repeat	550..565	CDD:275380	1/14 (7%)
		LRR 15	571..592		4/20 (20%)
		leucine-rich repeat	572..595	CDD:275380	5/22 (23%)
		LRR 16	595..616		3/21 (14%)
		leucine-rich repeat	596..645	CDD:275380	9/49 (18%)
		LRR 17	621..644		5/22 (23%)
		LRR_8	645..703	CDD:290566	9/58 (16%)
		LRR_4	645..685	CDD:289563	8/40 (20%)
		LRR 18	645..666		1/20 (5%)
		leucine-rich repeat	646..669	CDD:275380	1/22 (5%)
		LRR 19	669..690		7/21 (33%)
		leucine-rich repeat	670..692	CDD:275380	7/22 (32%)
		LRR 20	692..713		2/20 (10%)
		leucine-rich repeat	693..714	CDD:275380	2/20 (10%)
		LRR 21	714..735		5/50 (10%)
		leucine-rich repeat	715..734	CDD:275380	5/36 (14%)
		LRR 22	737..758		4/20 (20%)
		leucine-rich repeat	738..764	CDD:275380	5/25 (20%)
		PP2Cc	784..1033	CDD:238083	51/258 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1060..1157		18/104 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1285..1323		7/36 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900