DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rut and Adcy5

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_001012783.3	Gene:	Adcy5 / 224129	MGIID:	99673	Length:	1262	Species:	Mus musculus

Alignment Length:	1196	Identity:	457/1196 - (38%)
Similarity:	667/1196 - (55%)	Gaps:	222/1196 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 RFENDELECLYQRYTLKLQRFSVLGVVALVFVLCGVMAALSLTFNNAATFHNIFNAIVCGLFAVV 81
            :|.:|:||.|||||..:|.:.|:..::|::.::|.||.|...........:....|...|:..::
Mouse   221 KFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQIAYLAVLAAAVGVILIM 285

  Fly    82 LVLLQCSVIKDHHLPTLCYGILLFTASICVVSMPTLGSVFPVDTKEVMAEGVWQIVFVVFLAYAM 146
            .||...:.....|:...||.::....::.||     |.:.|  .....:||:|..||.::..|.:
Mouse   286 AVLCNRAAFHQDHMGLACYALIAVVLAVQVV-----GLLLP--QPRSASEGIWWTVFFIYTIYTL 343

  Fly   147 MPLQIWEAVAFGIALPSVHISLTVYKIFTDALRYLEYNQLIANIVIFIGVNVAGLVVNIMMERAQ 211
            :|:::..||..|:.|.::|::::::   |::.......||::|::||...|:.|:..:...|.:|
Mouse   344 LPVRMRAAVLSGVLLSALHLAISLH---TNSQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQ 405

  Fly   212 RRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDILSPVAG-QFHRIYIQKHENVS 275
            |:.|.:||.||.:||..|.||::.|||||||||:||||:||.||.:.... .||:||||||:|||
Mouse   406 RQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVS 470

  Fly   276 ILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYYCVSGLPEPRKDHA 340
            ||||||.|||.|:|||:|||||..|||||.|||:||.:|||||||||||||||||||||.|.|||
Mouse   471 ILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHA 535

  Fly   341 KCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDVTLANHMESGG 405
            .|.||||:|||:||:.|.|.|.|.:|||||||:|||.|||||||||||||||||||||||||:||
Mouse   536 HCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGG 600

  Fly   406 EPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFFIVPPPHRRKPLMLNTLGVRSAIG 470
            :.||:|:|:|||:.|:|:||||.|.|.:|::||::|.::||.|:....:||.        ..|:
Mouse   601 KAGRIHITKATLNYLNGDYEVEPGCGGDRNAYLKEHSIETFLILSCTQKRKE--------EKAM- 656

  Fly   471 SRRKLSFRNVSNVVMQLLHTIKFSEP-----VPFSNIATGSFPSAASALGGGVSVGGGGGGGGGG 530
                     ::.:..|..::|..:.|     .||.|           .|||.
Mouse   657 ---------IAKMNRQRTNSIGHNPPHWGAERPFYN-----------HLGGN------------- 688

  Fly   531 VARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYGSVVGSGGGVDSGISGGGGCVSG 595
                          |||::..|                 ||:
Mouse   689 --------------QVSKEMKR-----------------MGF----------------------- 699

  Fly   596 GIAGGGGVQVTVGTNPNSTASTISRIHRHNHKNNKSQSKVADKFKRPFRKRHSVAAHHQPTNRVN 660
                                        .:.|:..:|...                  .|.:.|:
Mouse   700 ----------------------------EDPKDKNAQESA------------------NPEDEVD 718

  Fly   661 RFLSQAINARSVDCDKSEHVDRLTLRFRQSDMEREYHKDFDLGFTTAMGCSLLLLILGAALQVTA 725
            .||.:||:|||:|..:||||.:..|.||:.|:|::|.|..|..|...:.|:.|:.:....:|:|.
Mouse   719 EFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITI 783

  Fly   726 LPRTLILLLLFLFAFIWVSAILML--------LLAVRLKWIIWDISESFSLRMAITIFTVILIYS 782
            :|.:|.:|..:|..|:.::.::.:        |....|:.:...|..|......:.:||:.|::.
Mouse   784 VPHSLFMLSFYLSCFLLLALVVFVSVIYACVKLFPTPLQTLSRKIVRSKKNSTLVGVFTITLVFL 848

  Fly   783 VGQVNVFTCVS---------DHPCSGNGTTS-----------------FQNDSHRKCSLPQYVSL 821
            ...||:|.|.|         :|..:.|...:                 |.......|:.|:|.:.
Mouse   849 SAFVNMFMCNSKNLVGCLAEEHNITVNQVNACHVMESAFNYSLGDEQGFCGSPQPNCNFPEYFTY 913

  Fly   822 SAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQNIFECYDNRVNAS------------ 874
            |...:.|:.||||::..|.|.:|:|.:..||.|.:|:....:|:..|..|.|:
Mouse   914 SVLLSLLACSVFLQISCIGKLVLMLAIEFIYVLIVEVPGVTLFDNADLLVTANAIDFSNNGTSQC 978

  Fly   875 ------IPLHLISLARIAIFMIAILVHGRLVEGTARLDFLWQLQASQEKKEMDVLQESNKRILHN 933
                  :.|.:::...|::|::|:.:|.:.||.||||||||:|||::||:||:.||..|:|:|||
Mouse   979 PEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHN 1043

  Fly   934 LLPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGLECLRLLNEIIAD 998
            :||..|||||| |:.|.|.|||:||...|.|:|||:.||:|||.|::.:::|:||||||||||||
Mouse  1044 ILPKDVAAHFL-ARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIAD 1107

  Fly   999 FDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEYKIQPND---PNSVRRHMTALIEYVKAMRHSLQ 1060
            |||::.|||||.::||||:||||||..||        ||   ..:.:.|:.|:.::...:...::
Mouse  1108 FDEIISEDRFRQLEKIKTIGSTYMAASGL--------NDSTYDKAGKTHIKAIADFAMKLMDQMK 1164

  Fly  1061 EINSHSYNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYSQVTQEVVDSL 1125
            .||.||:|||.:::|:||||||||||||||||||||||||||||||||||||...|||.::...|
Mouse  1165 YINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVL 1229

  Fly  1126 VGSHFEFRCRGTIKVKGKGDMVTYFL 1151
            ..:.::..|||.:||||||:|:||||
Mouse  1230 AANTYQLECRGVVKVKGKGEMMTYFL 1255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	75/237 (32%)
		CYCc	230..425	CDD:214485	143/195 (73%)
		Guanylate_cyc	266..438	CDD:278633	129/171 (75%)
		DUF1053	624..696	CDD:283888	21/71 (30%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	40/202 (20%)
		CYCc	924..1134	CDD:214485	118/212 (56%)
		Guanylate_cyc	954..1151	CDD:278633	112/199 (56%)
Adcy5	NP_001012783.3	AC_N	1..459	CDD:292831	77/247 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..194
		CYCc	425..620	CDD:214485	143/194 (74%)
		Guanylate_cyc	461..622	CDD:278633	124/160 (78%)
		DUF1053	669..761	CDD:283888	37/215 (17%)
		CYCc	1037..1238	CDD:214485	117/209 (56%)
		Guanylate_cyc	1063..1257	CDD:278633	114/201 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.710