DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rut and Adcy2

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_705762.2	Gene:	Adcy2 / 210044	MGIID:	99676	Length:	1095	Species:	Mus musculus

Alignment Length:	1227	Identity:	445/1227 - (36%)
Similarity:	628/1227 - (51%)	Gaps:	228/1227 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AVKATRGRPLNTLRFENDELECLYQRYTLKLQR-----FSVLGVVALVFVLCGVMAALSLTFNNA 63
            |..|..|..|...|      :.||:.|....|:     |.:|.|:.....|..|..||.|...:.
Mouse    21 AAAAGGGEGLQRSR------DWLYESYYCMSQQHPLIVFLLLIVMGACLALLAVFFALGLEVEDH 79

  Fly    64 ATFHNIFNAIVCGLFAVVLVLLQCSVIKDHHLPTLCYGILLFTAS----ICVVSMPTLGSVFPVD 124
            ..|.......:...||:.:::...||.|.          ||...|    ||:|:|   |.:|...
Mouse    80 VAFLITVPTALAIFFAIFILVCIESVFKK----------LLRVFSLVIWICLVAM---GYLFMCF 131

  Fly   125 TKEVMAEGVWQ----IVFVVFLAYAMMPLQIWEAVAFGIALPSVH-ISLTVYKIFTDALRYLEYN 184
            ...|.|   |.    .:|::|:.|.|:|..:.:|:...:...|.| |.|:||...|...:...:.
Mouse   132 GGTVSA---WDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVYLSATPGAKEHLFW 193

  Fly   185 QLIANIVIFIGVNVAGLVVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAM 249
            |::||::|||..|:||.....:||.|.::|:.||.|||.||::::.|..:.||||||:||.|:||
Mouse   194 QILANVIIFICGNLAGAYHKHLMELALQQTYRDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAM 258

  Fly   250 QMKNDIL----SPVAGQ------FHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELF 304
            :||.:|:    .|.|||      ||.:|:::|.|||||:|||||||.|:|.||..|||.:|||||
Mouse   259 EMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELF 323

  Fly   305 GRFDQLAHDNHCLRIKILGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRV 369
            |:|||:|.:|.|:||||||||||||||||....:|||..|:|||||.:||..|.:||.|.:||||
Mouse   324 GKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRV 388

  Fly   370 GIHTGRVLCGVLGLRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDER 434
            |:|:|.|||||:||:|||:||||:|||||||||:||.|||||::..||:.|:|.|:||.|.|:.|
Mouse   389 GVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGEIR 453

  Fly   435 SSYLRDHGVDTFFIV-PPPHRRKPLMLNTLGVRSAIGSRRKLSFRNVSNVVMQLLHTIKFSEPVP 498
            ..||:.|.|.|:|:: |...||.|..|                ||.        .||:
Mouse   454 DPYLKQHLVKTYFVINPKGERRSPQHL----------------FRP--------RHTL------- 487

  Fly   499 FSNIATGSFPSAASALGGGVSVGGGGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKILH- 562
                                         .|...|.|                   :|:.:.|.
Mouse   488 -----------------------------DGAKMRAS-------------------VRMTRYLES 504

  Fly   563 ---ATPPPHGMGYGSVVGSGGGVDSGISGGGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRH 624
               |.|..|.....|:....|.:.:                  ..|.:|              :|
Mouse   505 WGAAKPFAHLHHRDSMTTENGKIST------------------TDVPMG--------------QH 537

  Fly   625 NHKN----NKSQSKVADKFKRPFRKRHSVAAHHQPTNRVNRFLSQAINARSVDCD--KSEHVDRL 683
            |.:|    .|||.|   :|:....:|                :.|||:..:....  |||.:.|:
Mouse   538 NFQNRTLRTKSQKK---RFEEELNER----------------MIQAIDGINAQKQWLKSEDIQRI 583

  Fly   684 TLRFRQSDMEREYHKDFDLGFTTAMGCSLLLLILGAALQVTALPRTLILLLLFLFAFIWVSAILM 748
            :|.|...::|:||.......|...:.|:.|:.:....:|:..||:|.||...|..||:.:..||.
Mouse   584 SLFFYNKNIEKEYRATALPAFKYYVTCACLIFLCIFIVQILVLPKTSILGFSFGAAFLSLIFILF 648

  Fly   749 LLLAVRL--------KWIIWDISESFSL------RMAITIFTVILIYSVGQVNVFTCVSDHPCSG 799
            :..|.:|        ..::|.:..|..:      |:::||.|..:|.::...|:|...:    |.
Mouse   649 VCFAGQLLQCSKKASASLLWLLKSSGIIANRPWPRISLTIVTTAIILTMAVFNMFFLSN----SE 709

  Fly   800 NGTTSFQNDSHRKCSLPQ---------------YVSLSAAFAFLSVSVFLRLPIIFKSLLVLGMG 849
            ..|....|.|:...|:|.               |...|.....:|.|||||:....|.|:::...
Mouse   710 ETTLPTANASNANVSVPDNQTAILHARNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVAL 774

  Fly   850 TIYGLFIELSHQNIFECYD----NRVNASIPLHLISLARIAIFMIAILVHGRLVEGTARLDFLWQ 910
            ..|.:.:..:|.::.:.|.    .|......|..:....::||.|.:||.||..|...||||||:
Mouse   775 VGYNIILLHTHAHVLDAYSQVLFQRPGIWKDLKTMGSVSLSIFFITLLVLGRQSEYYCRLDFLWK 839

  Fly   911 LQASQEKKEMDVLQESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEF 975
            .:..:|::|::.::..|:.:|.|:||||||.||| |:...|.|||||||..|.|:|||:|:|.||
Mouse   840 NKFKKEREEIETMENLNRVLLENVLPAHVAEHFL-ARSLKNEELYHQSYDCVCVMFASIPDFKEF 903

  Fly   976 YTEMDGSDQGLECLRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGL--IPEYKIQPNDP 1038
            |||.|.:.:||||||||||||||||:||.:.:|.|::||||:||||||..||  :|..: ...:|
Mouse   904 YTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQE-HAQEP 967

  Fly  1039 NSVRRHMTALIEYVKAMRHSLQEINSHSYNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVA 1103
            .....|:..::|:..|:...|..||.||:|:|.||||||.|||:||||||:||||||||||||||
Mouse   968 ERQYMHIGTMVEFAYALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVA 1032

  Fly  1104 SRMDSTGVPGYSQVTQEVVDSLVGSHFEFRCRGTIKVKGKGDMVTYFLCDSGNKSLN 1160
            ||||||||....|||:|....|....:...|||.|.||||||:.|||:....::||:
Mouse  1033 SRMDSTGVLDKIQVTEETSLILQTLGYTCTCRGIINVKGKGDLKTYFVNTEMSRSLS 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	78/251 (31%)
		CYCc	230..425	CDD:214485	126/204 (62%)
		Guanylate_cyc	266..438	CDD:278633	111/171 (65%)
		DUF1053	624..696	CDD:283888	19/77 (25%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	37/183 (20%)
		CYCc	924..1134	CDD:214485	120/211 (57%)
		Guanylate_cyc	954..1151	CDD:278633	117/198 (59%)
Adcy2	NP_705762.2	AC_N	<37..264	CDD:292831	77/242 (32%)
		CYCc	240..443	CDD:214485	126/202 (62%)
		Guanylate_cyc	285..469	CDD:278633	117/183 (64%)
		DUF1053	499..603	CDD:283888	29/154 (19%)
		CYCc	852..1060	CDD:214485	120/209 (57%)
		Guanylate_cyc	882..1081	CDD:278633	118/199 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710