DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rut and gcy-25

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_001294116.1	Gene:	gcy-25 / 191653	WormBaseID:	WBGene00001549	Length:	1034	Species:	Caenorhabditis elegans

Alignment Length:	331	Identity:	83/331 - (25%)
Similarity:	150/331 - (45%)	Gaps:	87/331 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   874 SIPLHLISL----------ARIAIFMIAILVH---GRLVEGT---ARLDFLWQLQASQEK----- 917
            |..:.|:|:          ||.|:..|...|:   |:.|:||   ..::.:.:..|:.|:
Worm   715 SFTMRLLSIIQQCWLYKPAARPALIKITDAVNREFGQDVKGTLIDQMIEMIDEYSANLEQIVAER 779

  Fly   918 -KEMDVLQESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYTEMDG 981
             :|::......:.:|:.|||..||     ...|:...:..:.::.|.::...|..|.:|
Worm   780 TRELEQDMSVTENLLYQLLPKSVA-----DSIRSGKTVVPEQHSSVTLLVVDVCQFTKF------ 833

  Fly   982 SDQGLEC--------LRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEYKIQPNDP 1038
                  |        |..|.|:.:.||.::::::   ..|::.||..|:...| |||.
Worm   834 ------CEAFIPVHILETLQELYSSFDNIVQKNK---AFKVENVGDAYLICSG-IPEM------- 881

  Fly  1039 NSVRRHMTALIE-------YVKAMR------HSLQEINSHSYNNFMLRVGINIGPVVAGVIGARK 1090
             |..||:..:.:       ::|..:      |:||           :::||..|.|.||::|:..
Worm   882 -SGFRHLREICKISLKLQAFMKTFKVRHRPSHTLQ-----------IKMGITSGAVAAGILGSTA 934

  Fly  1091 PQYDIWGNTVNVASRMDSTGVPGYSQVTQEVVDSLVGS--HFEFRCRGTIKVKGKGDMVTYFLCD 1153
            |::.|:|:|||:|.||.|||.||..|:::...::|:..  .|....||.|.|||||..:|::|
Worm   935 PRFCIFGDTVNMACRMASTGNPGSIQLSELTANTLMEKFPSFMLEERGMIDVKGKGACLTFWL-- 997

  Fly  1154 SGNKSL 1159
            :|.|.:
Worm   998 TGEKDI 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831
		CYCc	230..425	CDD:214485
		Guanylate_cyc	266..438	CDD:278633
		DUF1053	624..696	CDD:283888
		SLC5-6-like_sbd	<742..>893	CDD:294310	7/28 (25%)
		CYCc	924..1134	CDD:214485	56/232 (24%)
		Guanylate_cyc	954..1151	CDD:278633	58/219 (26%)
gcy-25	NP_001294116.1	PBP1_iGluR_N_LIVBP_like	56..>230	CDD:107346
		PKc_like	473..746	CDD:304357	7/30 (23%)
		SPS1	474..>736	CDD:223589	4/20 (20%)
		HNOBA	<764..805	CDD:285003	9/45 (20%)
		CYCc	790..976	CDD:214485	55/225 (24%)
		Nucleotidyl_cyc_III	812..999	CDD:299850	59/223 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810