DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rut and gcy-23

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_500309.3	Gene:	gcy-23 / 191652	WormBaseID:	WBGene00001548	Length:	1073	Species:	Caenorhabditis elegans

Alignment Length:	363	Identity:	103/363 - (28%)
Similarity:	162/363 - (44%)	Gaps:	78/363 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   848 MGTIYGLFIELSHQNIFEC--YDNRVNASIPLHLI------------SLARIAIFMIAIL----- 893
            ||.||. |..:.|:.:|..  :.|..|.|..:..|            ...:|...::|:|
Worm   725 MGDIYA-FGMVMHEILFRALPFPNGTNVSEVMDYIRDGTKTFRPTVHDRTQIHPDLVALLLDCWN 788

  Fly   894 ---------------------VHGRLVEGTARLDFLWQLQASQEK---KEMDVLQESNKR---IL 931
                                 |.|.||:...|:  :.|...:.||   :...:|:|:|.|   :|
Worm   789 ENPEVRPSIRRVRLNTENYLKVKGSLVDQMMRM--MEQYANNLEKLVAERTGMLEEANVRADKLL 851

  Fly   932 HNLLPAHVAAHFLDAQFRNNMELYHQSYAK----VGVIFASVPNFNEFYTEMDGSDQGLECLRLL 992
            ..|||.:||         |.:::.....||    ..|:|:.:..|    |.:..|...||.:.:|
Worm   852 GQLLPKYVA---------NELKMGRSVPAKTFDMATVMFSDIVGF----TTICSSSTPLEVVSML 903

  Fly   993 NEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEYKIQPNDPNSVRRHMTALIEYVKAMRH 1057
            |.|.:.||:.:.:   .|..|::|:|..||.|.| |||    .|....:|......:|.:..::
Worm   904 NSIYSKFDDAINK---HGSYKVETIGDAYMIVSG-IPE----ENGNEHIRNICNTALELMLLLK- 959

  Fly  1058 SLQEINSHSYNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYSQVTQEVV 1122
             ..||.........:|:||:.|.|.|||:|...|:|.::|:||||||||:||..|...|::||..
Worm   960 -TYEIPHRRNVKLRIRLGIHTGTVAAGVVGLTAPRYCLFGDTVNVASRMESTSEPEKIQMSQEAR 1023

  Fly  1123 DSLVG--SHFEFRCRGTIKVKGKGDMVTYFLCDSGNKS 1158
            |..|.  |.|:...|||::.||||.:.:|:|....::|
Worm  1024 DFCVRYYSEFQITLRGTVEAKGKGPVTSYWLLGKQSES 1061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831
		CYCc	230..425	CDD:214485
		Guanylate_cyc	266..438	CDD:278633
		DUF1053	624..696	CDD:283888
		SLC5-6-like_sbd	<742..>893	CDD:294310	13/58 (22%)
		CYCc	924..1134	CDD:214485	70/218 (32%)
		Guanylate_cyc	954..1151	CDD:278633	68/202 (34%)
gcy-23	NP_500309.3	Periplasmic_Binding_Protein_Type_1	38..407	CDD:299141
		ANF_receptor	38..385	CDD:279440
		PK_GC	509..806	CDD:270894	14/81 (17%)
		HNOBA	<817..863	CDD:285003	15/56 (27%)
		CYCc	842..1035	CDD:214485	70/215 (33%)
		Guanylate_cyc	869..1056	CDD:278633	69/200 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810