DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rut and gcy-13

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_506097.3	Gene:	gcy-13 / 191646	WormBaseID:	WBGene00001539	Length:	1028	Species:	Caenorhabditis elegans

Alignment Length:	208	Identity:	67/208 - (32%)
Similarity:	118/208 - (56%)	Gaps:	15/208 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 EIQDENEKLERLLLSVLPQHVAMQMKNDILSPVAGQFHRIYIQKHENVSILFADIVGFTVLSSQC 291
            |:.:|.:|.:.||..:|||.||.::|       .||  .:..:..|:|:|.|:|:||||||:::.
Worm   805 ELVEEKKKSDILLYRMLPQQVAERLK-------LGQ--SVEPEAFESVTIFFSDVVGFTVLANKS 860

  Fly   292 SAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYYCVSGLPEPR-KDHAKCAVEMGLDMIDAIA 355
            :..::|.|||:|:..||.:...|...:::.:||.|..|||||... .:|......|.|:::|::.
Worm   861 TPLQVVNLLNDLYTTFDAIIEKNDSYKVETIGDAYLVVSGLPRRNGTEHVANIANMSLELMDSLQ 925

  Fly   356 T--VVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLD 418
            .  :.......:.:|:|:|:|..:.||:||...::.::.:.|..|:.|||.|:||.:|::....|
Worm   926 AFKIPHLPQEKVQIRIGMHSGSCVAGVVGLTMPRYCLFGDTVNTASRMESNGKPGFIHLSSDCYD 990

  Fly   419 ---SLSGEYEVEA 428
               ||..||..|:
Worm   991 LLTSLYKEYNTES 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	11/27 (41%)
		CYCc	230..425	CDD:214485	64/200 (32%)
		Guanylate_cyc	266..438	CDD:278633	54/169 (32%)
		DUF1053	624..696	CDD:283888
		SLC5-6-like_sbd	<742..>893	CDD:294310
		CYCc	924..1134	CDD:214485
		Guanylate_cyc	954..1151	CDD:278633
gcy-13	NP_506097.3	PBP1_NPR_GC_like	3..397	CDD:107347
		ANF_receptor	13..368	CDD:279440
		PKc_like	548..770	CDD:304357
		HNOBA	<797..829	CDD:285003	10/23 (43%)
		CYCc	808..1000	CDD:214485	64/200 (32%)
		Guanylate_cyc	835..1022	CDD:278633	54/169 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810