DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rut and gcy-3

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_496037.1	Gene:	gcy-3 / 191641	WormBaseID:	WBGene00001530	Length:	1140	Species:	Caenorhabditis elegans

Alignment Length:	231	Identity:	67/231 - (29%)
Similarity:	128/231 - (55%)	Gaps:	21/231 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 EIQDENEKLERLLLSVLPQHVAMQMKNDILSPVAGQFHRIYIQKHENVSILFADIVGFTVLSSQC 291
            |:..|.:|.:.||..:||:.||.::|       |||  .:..:..::|::.|:|:|.||:|:|:|
Worm   858 ELTLEKKKADLLLSRMLPKQVAERLK-------AGQ--TVEPEGFDSVTVFFSDVVKFTILASKC 913

  Fly   292 SAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYYCVSGLPEPRK-DHAKCAVEMGLDMIDAIA 355
            :..::|.|||:|:..||.:..::...:::.:||.|.||||||.... :|.|..|:|.|..:|...
Worm   914 TPFQVVNLLNDLYSNFDTIIEEHGVYKVESIGDGYLCVSGLPTRNGFNHIKQIVDMSLKFMDYCK 978

  Fly   356 T--VVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDVTLANHMESGGEPGRVHVTR---- 414
            .  :.......:.:|:|:::|..:.||:||...::.::.:.|..|:.|||.|:|..:|:|.
Worm   979 NFKIPHLPRERVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSLIHLTSDAHL 1043

  Fly   415 ATLDSLSGEYEVEAGHGDERSSYLRDHGV-DTFFIV 449
            ..:.....:||..: .|:   ..::..|| :||:::
Worm  1044 LLMKHFPHQYETNS-RGE---VIIKGKGVMETFWVL 1075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	10/27 (37%)
		CYCc	230..425	CDD:214485	59/201 (29%)
		Guanylate_cyc	266..438	CDD:278633	50/178 (28%)
		DUF1053	624..696	CDD:283888
		SLC5-6-like_sbd	<742..>893	CDD:294310
		CYCc	924..1134	CDD:214485
		Guanylate_cyc	954..1151	CDD:278633
gcy-3	NP_496037.1	PBP1_NPR_GC_like	36..453	CDD:107347
		ANF_receptor	54..433	CDD:279440
		PKc_like	554..823	CDD:304357
		HNOBA	<839..882	CDD:285003	9/23 (39%)
		CYCc	861..1051	CDD:214485	59/198 (30%)
		Guanylate_cyc	888..1076	CDD:278633	54/192 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810