Protein Alignment rut and phlp-2

DIOPT Version :9

• Sequence 1: NP_511156.2
• Gene: rut / 32406
• FlyBaseID: FBgn0003301
• Length: 2248
• Species: Drosophila melanogaster
• Sequence 2: NP_001337270.1
• Gene: phlp-2 / 185690
• WormBaseID: WBGene00009647
• Length: 1126
• Species: Caenorhabditis elegans
• Alignment Length: 850
• Identity: 156/850 - (18%)
• Similarity: 278/850 - (32%)
• Gaps: 292/850 - (34%)

  Fly   657 NRVNRFLSQAINARSVDCDKSEHVD--RLT-LRFRQSDMEREYHKDFDLGFTTAMGCSLLLL--- 715
            :||.....|.|:.|....|.|..:|  .:| |..|.:.|....|.. :|.|...:.|..|.|
 Worm   394 DRVGEMQIQKIDLRRNVLDTSFRLDIENITHLDLRDNSMISTVHLT-NLRFLKVIHCERLQLSSL 457

  Fly   716 -ILGAALQVTALPRTLILLLLFLFAFIWVSAILMLLLAVRLKWIIWDISESFSLRMAITIFTVIL 779
             :.|.:|........|:            .:::::.|...|:          :|.::...|.
 Worm   458 HLSGESLTHVYADHNLL------------DSLVVMPLPQNLQ----------TLSLSFNHFR--- 497

  Fly   780 IYSVGQVNVFTCVSDHPCSGNGTTSFQNDSHRKCSLPQYV----SLSAAFAFLSVSVFLRLPIIF 840
                   |:...:||.|    ..|..:.:::...:||:.:    ||.:.|||::
 Worm   498 -------NLPDWISDCP----NLTFLRANNNSLVALPERIFYSQSLRSIFAFIN----------- 540

  Fly   841 KSLLVLGMGTIYGLFIELSH------QNIFE---CYDNRVNASIPLHLISLARIAIFMIAILVHG 896
                            |:.|      :|..|   .|.|:: :|:|.|..|:
 Worm   541 ----------------EIEHIPDFGEENCLETLILYKNKL-SSLPKHFFSI-------------- 574

  Fly   897 RLVEGTARLDFLWQLQASQEKKE------------MDVLQESNKRILHNLLPAHVAAHFLDAQFR 949
                    |..|.||..|....|            :.:|:.:|..:..|.:|..|.        .
 Worm   575 --------LPRLRQLNISSNFIELLPYFDGSSFCRLQILRCANNYLTENSVPVIVN--------M 623

  Fly   950 NNMELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGL----ECLRL---LNEIIADFDELLKEDR 1007
            .::::...|:.::.....|..:..|...:::.|...|    :||.|   |..:.|..::|:....
 Worm   624 KHLKIIDLSHNRLNSFDDSALSSLELLEDLNLSSNRLTRLADCLALLPCLQVLRAHSNQLVHVPE 688

  Fly  1008 FRGIDKIKTVG-STYMAVVGLIPEYKIQPNDPNSVRRHMTALIEY---------VKAMRHSLQ-- 1060
            ||..:::.|:. |:....:|.: ::|..||     .||.......         ..|..||..
 Worm   689 FRASNQLHTIDVSSNNISLGTL-QFKAPPN-----LRHFDVTCNSGDFDTENFPENAKMHSKMNT 747

  Fly  1061 -EINSHSYNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGY---------- 1114
             .|:..|.|.|..::|      |:|..|.:..|........|....:|. |...|
 Worm   748 INISEGSQNLFGFQIG------VSGSRGMKNKQCIRQVRVENTFGFIDG-GSNSYMSSSICRFMT 805

  Fly  1115 ----SQVTQEVVDSLVGSHFEFRCRGTIKVKGKGDMVTYFLCDSGNKSL----NGEVRNAMSLPQ 1171
                ..|:.::...|:      ||...:..:|:....:..:.....|.|    .|.:..|::..|
 Worm   806 SYLKENVSMDIRSILL------RCHCELGEEGERLGASVMIIRVHEKRLEIASTGTMSAAIARNQ 864

  Fly  1172 SLHA---------PDYYMKVSQF-----PENRVNTDTYSKKENGHLYAGNGVEEQQLLLQHQHKQ 1222
            .|..         .|.|.::.:.     .|||:|....|.::.||.                  .
 Worm   865 KLKMIINGRYEIDDDEYSRIREAHGFVDEENRINGVIGSSRQIGHF------------------S 911

  Fly  1223 HDPLPLPAPPPPVHHHLHQQQQQRLNSKLQKQPIFMANGGLPNIRE----NGNGHNGEH-----Q 1278
            ..|:.||.         |..:..:||.::  :.:.:.|..:.|:..    |...||...     :
 Worm   912 TFPVVLPT---------HSYRNIQLNEQI--EGLIVGNNMIWNMLSIDDLNSTFHNNRSPIVVAK 965

  Fly  1279 QQQQQQQQHQ----------QQQQQQQQHGGFMVATT----TPPAAV---------AVP--LQPQ 1318
            :.|.|.|.:.          ::.:.|....||..::|    ||..|:         |||  :.|:
 Worm   966 KIQDQLQSYDYGGNSNILVLRRIKPQMTFNGFSTSSTKNQVTPDIAIPKIDEQLVLAVPALILPE 1030

  Fly  1319 HHQL--------QFQH----PHQHPLPSAVSVPVQHQILLHHQLQLQHQPVPSVMLREFNIIENP 1371
            :|..        ..:|    |...||||:...||..          :|:        |.|:.::.
 Worm  1031 YHPSPPVPPPIPAIRHRTPSPPPPPLPSSTPPPVSS----------EHE--------EINVRQSS 1077

  Fly  1372 T-SGG 1375
            | |||
 Worm  1078 TLSGG 1082

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831
		CYCc	230..425	CDD:214485
		Guanylate_cyc	266..438	CDD:278633
		DUF1053	624..696	CDD:283888	12/41 (29%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	26/163 (16%)
		CYCc	924..1134	CDD:214485	43/243 (18%)
		Guanylate_cyc	954..1151	CDD:278633	42/230 (18%)
phlp-2	NP_001337270.1	leucine-rich repeat	232..253	CDD:275380
		leucine-rich repeat	254..288	CDD:275380
		PLN00113	283..>718	CDD:331614	77/424 (18%)
		leucine-rich repeat	289..311	CDD:275380
		leucine-rich repeat	312..334	CDD:275380
		leucine-rich repeat	335..357	CDD:275380
		leucine-rich repeat	358..379	CDD:275380
		leucine-rich repeat	380..440	CDD:275380	13/46 (28%)
		leucine-rich repeat	441..485	CDD:275380	9/55 (16%)
		leucine-rich repeat	486..508	CDD:275380	7/45 (16%)
		leucine-rich repeat	509..534	CDD:275380	5/24 (21%)
		leucine-rich repeat	554..577	CDD:275380	8/45 (18%)
		leucine-rich repeat	578..602	CDD:275380	5/23 (22%)
		leucine-rich repeat	603..625	CDD:275380	5/29 (17%)
		leucine-rich repeat	626..649	CDD:275380	2/22 (9%)
		leucine-rich repeat	650..672	CDD:275380	5/21 (24%)
		leucine-rich repeat	673..694	CDD:275380	5/20 (25%)
		PP2Cc	754..985	CDD:214625	46/272 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900