DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rut and Npr1

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_032753.5	Gene:	Npr1 / 18160	MGIID:	97371	Length:	1057	Species:	Mus musculus

Alignment Length:	481	Identity:	119/481 - (24%)
Similarity:	204/481 - (42%)	Gaps:	97/481 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RGRPLNTLRFENDELECLYQRYTLKLQRFSVLGVVALVFVLCGVMAALSLTFNNAATFHNIF--- 70
            ||...:.|..|:..|:.:: ||:|...                ::..:....|.|...|...
Mouse   613 RGSLQDILENESITLDWMF-RYSLTND----------------IVKGMLFLHNGAIGSHGNLKSS 660

  Fly    71 NAIVCGLFAVVLVLLQCSVIKD------HHLPTLCYGILLFTAS--ICVVSMPTLGS------VF 121
            |.:|.|.|.:.:........:|      |.|    :...|:||.  :.:.|.|..||      .|
Mouse   661 NCVVDGRFVLKITDYGLESFRDPEPEQGHTL----FAKKLWTAPELLRMASPPARGSQAGDVYSF 721

  Fly   122 PVDTKEV-MAEGVWQIVFVVFLAYAMMPLQIWEAVAFGIALPSVHISLTVYKIFTDALRYLE--- 182
            .:..:|: :..||:.:.     ...:.|.:|.|.|..|...|        ::...|...:||
Mouse   722 GIILQEIALRSGVFYVE-----GLDLSPKEIIERVTRGEQPP--------FRPSMDLQSHLEELG 773

  Fly   183 ----------------YNQLIANIVIFIGVNVAGLVVNIMMERAQRRTFLDTRNCIASRLEIQ-D 230
                            :.|:...:..|...|.:.::.|::....|....|:  ..:..|.:.. :
Mouse   774 QLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDNLLSRMEQYANNLE--ELVEERTQAYLE 836

  Fly   231 ENEKLERLLLSVLPQHVAMQMKNDILSPVAGQFHRIYIQKHENVSILFADIVGFTVLSSQCSAQE 295
            |..|.|.||..:||..||.|:|..         ..:..:..::|:|.|:||||||.||::.:..:
Mouse   837 EKRKAEALLYQILPHSVAEQLKRG---------ETVQAEAFDSVTIYFSDIVGFTALSAESTPMQ 892

  Fly   296 LVRLLNELFGRFDQLAHDNHCLRIKILGDCYYCVSGLPEPRKD-HAKCAVEMGLDMIDAIAT--V 357
            :|.|||:|:..||.:..:....:::.:||.|..|||||..... ||:....|.|.::||:.:  :
Mouse   893 VVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRI 957

  Fly   358 VEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDVTLANHMESGGEPGRVHV---TRATLDS 419
            .......|.:|:|||||.|..||:||:..::.::.:.|..|:.|||.||..|:|:   |:|.|:.
Mouse   958 RHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHLSSETKAVLEE 1022

  Fly   420 LSGEYEVE-------AGHGDERSSYL 438
            ..| :|:|       .|.|..|:.:|
Mouse  1023 FDG-FELELRGDVEMKGKGKVRTYWL 1047

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	53/275 (19%)
		CYCc	230..425	CDD:214485	68/200 (34%)
		Guanylate_cyc	266..438	CDD:278633	62/184 (34%)
		DUF1053	624..696	CDD:283888
		SLC5-6-like_sbd	<742..>893	CDD:294310
		CYCc	924..1134	CDD:214485
		Guanylate_cyc	954..1151	CDD:278633
Npr1	NP_032753.5	PBP1_NPR_A	32..439	CDD:107380
		ANF_receptor	50..410	CDD:279440
		PK_GC-A_B	530..803	CDD:270944	40/223 (18%)
		TyrKc	543..797	CDD:197581	39/217 (18%)
		HNOBA	<812..857	CDD:285003	12/46 (26%)
		CYCc	836..1025	CDD:214485	67/197 (34%)
		Guanylate_cyc	863..1049	CDD:278633	63/186 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810