DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rut and gcy-33

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_001256392.1	Gene:	gcy-33 / 179644	WormBaseID:	WBGene00001553	Length:	947	Species:	Caenorhabditis elegans

Alignment Length:	822	Identity:	172/822 - (20%)
Similarity:	302/822 - (36%)	Gaps:	232/822 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   661 RFLSQAINARSVDCDKSEHVDRLTLRFRQS-------------DMEREYHKDFDLG--------- 703
            ||....:.|.|..| |||..|.|.|.:|..             ::.|.::: .|:|
Worm   108 RFSYPKLRAPSFYC-KSESEDGLILHYRSRRTGYLSYVIGQLVELARVFYQ-LDIGIQVLKKKEK 170

  Fly   704 --FT-TAMGCSLLLLILGAALQVTA--------LP---RTLILLLLFLFAFIWVSAILM-----L 749
              || ..:..|...:.||..|::..        ||   ::.:.:..|..||.....|||     |
Worm   171 GRFTFVVLKISFDNVGLGQDLKLKERVKNLNEYLPVDTKSFLQMFPFHIAFNKKLEILMAGQGLL 235

  Fly   750 LLAVRLKWIIWDISESFSLRMAITIFTV--ILIYSVGQVNVFTCVSDHP----CSGNGTTSFQND 808
            .|...::.::  :::.|.|:.....||.  |:::   |..||...|.||    ...|.|....:.
Worm   236 NLMPNIQGLL--MTDVFDLQRPCIKFTAEGIMVH---QNCVFQIESLHPVVKQTEENITVQINDI 295

  Fly   809 SHRKCSLPQYVSLSAAFAFLSVS-VFLRLPI-IFKS---LLVLG------MGTIYGLFIELSHQN 862
            :..|.||.:...:...:...|:. |.||.|| :.||   .|:|.      :.|::.:.:.|:...
Worm   296 TEDKVSLEKKTVMDNEYGLESLPYVTLRGPITVLKSSETFLLLATCVVDTLDTMFKMGLYLNDFG 360

  Fly   863 IFECYDNRVNASIPLHLISLARIAIFMIAILVHGRLVEGTARLDFLWQLQASQEKKEMDVLQESN 927
            ..:|  ||                          .::..|.:.....:.....||:..:||.|..
Worm   361 ESDC--NR--------------------------EIIMATIQKSDTLKTMLENEKRRSEVLTEMT 397

  Fly   928 KRI----------LHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYTEMDGS 982
            :.|          |..::|..||    ....|:....:.:::..|.:.|..|.:|::....:
Worm   398 REISEAKKTARTLLTQMMPYEVA----QTMMRSGSVDHCEAFECVSIGFIRVCDFSKISLFI--- 455

  Fly   983 DQGLECLRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEYKIQPNDPNSVRRHMTA 1047
             :..|.:.|||.|.:..|.::..   .|:.|::|:|.:||...|.  .|: ...|...|......
Worm   456 -EAFEVVNLLNTIYSHLDSIVDT---HGVYKVETIGESYMISAGC--PYR-DDYDAEMVSDCCLE 513

  Fly  1048 LIEYVKAMRHSLQEINSH-SYNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTG- 1110
            ::.::|:.     |..|| :....:::.||..||||.||:|.|.|:|.::|:|||.||||:|:.
Worm   514 MVSHIKSF-----EYQSHDAVKKVLIKCGIFTGPVVGGVVGVRTPRYCLFGDTVNTASRMESSNQ 573

  Fly  1111 VPGYSQV---TQEVVDSLVGSHFEFRCRGTIKVKGKGDMVTY----------------------- 1149
            .|...|:   |::.|:......|..:.:|.:.|||||||..|
Worm   574 TPMTIQIGQRTKDRVEKQASGAFRIKPKGNVFVKGKGDMRVYEIEKKKGRARYKKSDPLRKKMVA 638

  Fly  1150 ------FLCDSGNKSLNGEVRNAMSLPQSLHAPDY---YMKVSQFPENRVNTDT--YSKKENGHL 1203
                  .|.|..|:.......:.|||.:|:.:...   .:..||...|:....|  .:.|.:..|
Worm   639 EKKEAEELLDEDNEGHRSSALSRMSLGESIDSSSSRRGSLSGSQLELNKTIAQTIELTSKASAAL 703

  Fly  1204 YAGNGVEEQQLLLQHQHKQHDPLPLPAPPPPVHHHLHQQQQQR---------LNSKLQKQPIFM- 1258
                     .|.:|.::.:          ||.....|.|..::         |||:|....:.:
Worm   704 ---------DLNMQDENNR----------PPTWSASHSQDIRKPRKTESKITLNSRLSSSDLAVS 749

  Fly  1259 -------ANGGLP-----------NIRENGNGHNGEHQQQQQQQQQHQQQ------------QQQ 1293
                   ::|..|           .|||.......|.::..:::.|..::            ...
Worm   750 RVETSKDSDGETPRPTSSELKEVNRIREEALAQEKEEERTTKEENQKIEEVGEDHVSEATSLLDS 814

  Fly  1294 QQQHGGFMVATTTPPAAVAVPLQPQHHQLQFQHPHQHPLPSA 1335
            :..||...::.:..|:. ::|           |..:..||||
Worm   815 EVSHGDNNISFSQMPSD-SIP-----------HEDRTSLPSA 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831
		CYCc	230..425	CDD:214485
		Guanylate_cyc	266..438	CDD:278633
		DUF1053	624..696	CDD:283888	13/47 (28%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	36/172 (21%)
		CYCc	924..1134	CDD:214485	57/224 (25%)
		Guanylate_cyc	954..1151	CDD:278633	59/230 (26%)
gcy-33	NP_001256392.1	HNOB	2..164	CDD:377902	15/57 (26%)
		HNOBA	204..423	CDD:369471	52/255 (20%)
		CYCc	402..598	CDD:214485	55/214 (26%)
		COG5134	<595..744	CDD:227463	33/167 (20%)
		TDA11	<710..>898	CDD:293689	24/157 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910