Protein Alignment rut and acy-4

DIOPT Version :9

• Sequence 1: NP_511156.2
• Gene: rut / 32406
• FlyBaseID: FBgn0003301
• Length: 2248
• Species: Drosophila melanogaster
• Sequence 2: NP_504486.4
• Gene: acy-4 / 178949
• WormBaseID: WBGene00000071
• Length: 1013
• Species: Caenorhabditis elegans
• Alignment Length: 1171
• Identity: 378/1171 - (32%)
• Similarity: 570/1171 - (48%)
• Gaps: 263/1171 - (22%)

  Fly    12 PLNTLRF----ENDELECLYQRYTLKLQRFSVLGVVALVFVLCGVMAALSLTFNNAATFHNIFNA 72
            |...||:    :..:...||..|..::..    |.:...||:     .||:..:.||     |:|
 Worm    63 PWEKLRYRKNSQKKKRSTLYSFYFEQVNS----GRIQFSFVI-----LLSICISEAA-----FSA 113

  Fly    73 IVC-GLFAVVLVLLQCSVIKDHHLPTLCYGILLF-----TASICVVSMPTLGSVFPVDTKEVMAE 131
            ... .|.:::|.:|           ||...||.|     |..:|:.|   :.|...:.....|..
 Worm   114 FGAEWLKSLILCIL-----------TLVISILSFFHAKRTELVCIAS---IISCVIISACTSMRT 164

  Fly   132 GVWQIVFVVFLAYAMMPLQIWEAVAFGIALPSVHISLTVYKIFTDALRYLEYNQ----LIANIVI 192
            .|..:  ::|..|:::|:      :|.:.:.|. .:||....|...|  ::||.    ::..:::
 Worm   165 SVTYL--LIFSTYSLLPM------SFMLMIFST-FALTFLVAFIGVL--MDYNVGFDIILTRVMM 218

  Fly   193 FIGVNVAGLVVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDIL- 256
            .|.|||.|.:|....|..||:||.:||.|:.||:.:..|..:.|::||:|||:::|.::|.|:.
 Worm   219 VILVNVVGSLVYYPTEFVQRKTFHETRKCVQSRMLLDKEMHRQEKILLAVLPKNIAFEVKKDMQE 283

  Fly   257 SPVAGQFHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKI 321
            :.....||:|||:|:|::|||||||.|||.|:|:.:.::||.:|||||.|||::|..:.|:||||
 Worm   284 THEERMFHKIYIRKYEDISILFADICGFTNLASEYNPKDLVLMLNELFARFDKVASIHQCMRIKI 348

  Fly   322 LGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRKW 386
            ||||||||.|:||.:|:||...||||.|||:||..|.|.|.|.:|||||||||:..||||||:||
 Worm   349 LGDCYYCVCGVPEYQKNHAINTVEMGRDMIEAIRLVREMTLVNVNMRVGIHTGKAHCGVLGLKKW 413

  Fly   387 QFDVWSNDVTLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFFIVPP 451
            |||||||||||||.|||||..||||:|.||...|.|.|.:|.|:|..||.:|....:.|:.:|.
 Worm   414 QFDVWSNDVTLANQMESGGLAGRVHITDATRSYLKGAYILEEGNGGSRSKFLEKEKIKTWLVVD- 477

  Fly   452 PHRRKPLMLNTLGVRSAIGSRRKLSFRNVSNVVMQLLHTIKFSEPVPFSNIATGSFPSAASALGG 516
               |.|                                        .:.||..
 Worm   478 ---RSP----------------------------------------DYDNICQ------------ 487

  Fly   517 GVSVGGGGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYGSVVGSGGG 581
                                 ||.:..|.|..|.:|.:.:.:::.                   |
 Worm   488 ---------------------EATNHPVMVPWKSTRGISKQERLT-------------------G 512

  Fly   582 VDSGISGGGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRHNHKNNKSQSKVADKFKRPFRKR 646
            :.:...|                          |||         :|..|:.:|.
 Worm   513 MSTRTRG--------------------------AST---------RNGLSEEEVL---------- 532

  Fly   647 HSVAAHHQPTNRVNRFLSQAINARSVDCDKSEHVDRLTLRFRQSDMEREY--HKDFDLGFTTAMG 709
                     ...|:..|.|.|.|...:..|:.|....:|:::|..:|.::  .|..|:.|...:.
 Worm   533 ---------VENVDSHLRQGIQAIHQENWKTMHCKNWSLKYKQVRVENKFVRLKYKDIPFQVTLY 588

  Fly   710 CSLLLLILGAALQVTALPRTLILLLLFLFA---FIWVSAILMLLLA------VRLKWIIWDISES 765
            .:::.:.:|       :...|:.|:.|.|.   ||.::::::.:|.      .||..::  |...
 Worm   589 VAIVAICIG-------IKFGLMNLVSFSFVPQMFIVLTSVMIFILTRALIKHARLVSLV--IGVL 644

  Fly   766 FSLRMAITIFTVILIYSVGQVNVFTCVSDHPCSGNGTTSFQNDSHRKCSLPQYVSLSAAFAFLSV 830
            |.| ::|.|..::.:|.    :.||| ....|..|..|.| .:....|:|...|.||..|    :
 Worm   645 FIL-LSIQIVILMGMYE----SKFTC-DVEKCFKNNYTDF-FEIFEICTLATCVILSVDF----M 698

  Fly   831 SVFLRLPIIFKSLLVLGMGTIYGLFIELS-HQNIFECYDNRVNASIPLHLISLARIAIFMIAILV 894
            :..|...|.|.|..||    |....|.:: ::.:...|.|....|           .:.::.::.
 Worm   699 TKLLMSMIYFSSFTVL----ITAKLIRINQYEALLSTYANFCVLS-----------CLTLLLVVF 748

  Fly   895 HGRLVEGTARLDFLWQLQASQEKKEMDVLQESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQSY 959
            ..|..|..:|.||:|:|||..|:.:|....|.|:.:|.|:||:|||.||:: ...:..:|||:|.
 Worm   749 STRRSELISRYDFIWKLQALDEQLQMKRKHEQNRSVLENILPSHVAKHFVE-DATSVSKLYHESR 812

  Fly   960 AKVGVIFASVPNFNEFYTEMDGSDQGLECLRLLNEIIADFDELLKE----DRFRGIDKIKTVGST 1020
            ....::||::..|::||.|.||:::|:||||||||||:|||::|.:    :.|:.|:||||:.:|
 Worm   813 DNACIMFATLTEFDKFYIECDGNNEGVECLRLLNEIISDFDQILDQILDREEFKKIEKIKTISTT 877

  Fly  1021 YMAVVGLIPEYKIQPNDPNSVRRHMTALIEYVKAMRHSLQEINSHSYNNFMLRVGINIGPVVAGV 1085
            ||...||...   :..| ||   |:.|:..:.:.:...|:..|.||:|||.||:|||:|||||||
 Worm   878 YMVASGLAGR---ECGD-NS---HVEAIALFARELLVKLESTNIHSFNNFNLRIGINVGPVVAGV 935

  Fly  1086 IGARKPQYDIWGNTVNVASRMDSTGVPGYSQVTQEVVDSLVGSHFEFRCRGTIKVKGKGDMVTYF 1150
            ||:.||.||||||:|||||||||.||.|..|||:||...|....:.|.|||.|.|||||.|.|:|
 Worm   936 IGSDKPHYDIWGNSVNVASRMDSGGVAGRIQVTEEVKSILEPLGYNFECRGQINVKGKGMMETFF 1000

  Fly  1151 L 1151
            |
 Worm  1001 L 1001

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	63/251 (25%)
		CYCc	230..425	CDD:214485	116/195 (59%)
		Guanylate_cyc	266..438	CDD:278633	110/171 (64%)
		DUF1053	624..696	CDD:283888	13/71 (18%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	33/157 (21%)
		CYCc	924..1134	CDD:214485	102/213 (48%)
		Guanylate_cyc	954..1151	CDD:278633	102/200 (51%)
acy-4	NP_504486.4	AC_N	<50..291	CDD:292831	66/266 (25%)
		CYCc	260..451	CDD:214485	115/190 (61%)
		Guanylate_cyc	293..448	CDD:278633	102/154 (66%)
		CYCc	778..984	CDD:214485	102/213 (48%)
		Guanylate_cyc	807..1003	CDD:278633	104/202 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	227	1.000	Domainoid score	I1420
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	605	1.000	Inparanoid score	I502
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.720