DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rut and gcy-18

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_502449.2	Gene:	gcy-18 / 178237	WormBaseID:	WBGene00001543	Length:	1113	Species:	Caenorhabditis elegans

Alignment Length:	304	Identity:	90/304 - (29%)
Similarity:	147/304 - (48%)	Gaps:	49/304 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   881 SLARIAIFMIAIL-VHGRLVEGTARLDFLWQLQASQEK---KEMDVLQESNKR---ILHNLLPAH 938
            |:.|:.:....:| ..|.||:...::  :.|...:.||   :...:|:|:|.|   :|..||||:
Worm   836 SIRRVRLNTEMVLKTKGSLVDQMMKM--MEQYANNLEKLVAERTGMLEEANIRADQLLTQLLPAY 898

  Fly   939 VAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGLECLRLLNEIIADFDELL 1003
            ||     .:.:....:..:.|:...::|:.:..|.   |...||.. ||.:.:||.:...|||.:
Worm   899 VA-----NELKMGRSVAPKLYSSATILFSDIVGFT---TICSGSTP-LEVVNMLNGLYTGFDECI 954

  Fly  1004 KEDRFRGIDKIKTVGSTYMAVVGLIPEYKIQPNDPNSVRRHMTALIEYVKAMRHSL--QEINSHS 1066
            ..::..   |::|:|..||.|.| |||    .|:.|..|......::    ||..|  .:|....
Worm   955 TRNKSY---KVETIGDAYMVVSG-IPE----ENEYNHSRNIANTALD----MRQYLTGYQIPHRP 1007

  Fly  1067 YNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYSQVTQEVVDSLVGSHFE 1131
            .:....|.|.:.|.|.|||:|...|:|.::|:||||:|||:|||.||..|:::|       :|..
Worm  1008 THRVRCRWGFHTGSVAAGVVGLTCPRYCLFGDTVNVSSRMESTGTPGMIQMSEE-------AHMH 1065

  Fly  1132 FRC---------RGTIKVKGKGDMVTYFLCDS-GNKSLNGEVRN 1165
            .|.         ||.::|||||...|::|.|. |:.|....::|
Worm  1066 IRAHHPVFTTTERGEVQVKGKGTCRTFWLEDRVGDASTTNYIQN 1109

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831
		CYCc	230..425	CDD:214485
		Guanylate_cyc	266..438	CDD:278633
		DUF1053	624..696	CDD:283888
		SLC5-6-like_sbd	<742..>893	CDD:294310	2/11 (18%)
		CYCc	924..1134	CDD:214485	66/214 (31%)
		Guanylate_cyc	954..1151	CDD:278633	65/207 (31%)
gcy-18	NP_502449.2	Periplasmic_Binding_Protein_Type_1	87..448	CDD:299141
		ANF_receptor	87..395	CDD:279440
		PKc_like	549..846	CDD:304357	2/9 (22%)
		HNOBA	<857..903	CDD:285003	14/52 (27%)
		CYCc	882..1073	CDD:214485	67/218 (31%)
		Guanylate_cyc	909..1095	CDD:278633	65/208 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810