DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rut and acy-3

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_497765.4	Gene:	acy-3 / 175489	WormBaseID:	WBGene00000070	Length:	1243	Species:	Caenorhabditis elegans

Alignment Length:	1267	Identity:	265/1267 - (20%)
Similarity:	476/1267 - (37%)	Gaps:	339/1267 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LVFVLCGVMAALSLTFNNAATFHNIFNAIVCGLFAVVLVLLQCSVIKDHHLPT--LCYGILLFTA 107
            ::|:..|  :|...|..:...|:.::.|::..|..|.::.   .:::...:..  :..||:|...
Worm    27 VLFITSG--SAFLRTLGHIPGFYALWTAVILLLSTVTIIF---HILRPARIAAFQILAGIVLLLD 86

  Fly   108 SICVVSMPTLGSVFPVDTKEVMAEGVWQIVFVVFLAYAMMPLQIWEAVAFGIALPSVHISLTVYK 172
              ...::|...|:||.             :..||..|....|..     :.|...|..||:....
Worm    87 --VAFALPGYESLFPA-------------LLAVFSLYTFFSLPF-----YAILATSTLISIVQTC 131

  Fly   173 IFTDALRYLEYNQLIANIVIFIGVNVAGLVVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLER 237
            .|...:..|..|:|:|.||:.|..|..|:.:....:|..|..||..||...:....:.::.:|.:
Worm   132 SFLLFVEPLHTNELLAIIVVHIWTNFTGIYLCSTADRLARNAFLSARNSSEAESTAEFQSNRLNK 196

  Fly   238 LLLSVLPQHVAMQMKNDI--LSPVAGQFHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLL 300
            ||.|.||.|:..|.::.|  ..|      .:|.:.:..||:.:..:|||..:.:|||:.:..|:|
Worm   197 LLSSFLPYHLINQARHQITLYKP------HLYNETYSQVSVAYGRLVGFESVLAQCSSIDAARVL 255

  Fly   301 NELFGRFDQLAHDNHCLRIKILGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVIL 365
            .||..|.::||..|.|.|:...|....|  .:|.....||.......:::...|.:..:||...:
Worm   256 KELDSRIERLAASNGCTRVASEGITAVC--SIPGIDSQHATKLCRFSMELETLINSFRDATGADV 318

  Fly   366 NMRVGIHTGRVLCGVLGLRKWQFDVWSNDVTLANHMESGG-EPGRVHV---TRATLDSLSGEYEV 426
            ::.:||.:|.|..||:|:.||.:||..:....|..|:|.. ||| |:|   ||..|.| :||:|:
Worm   319 SVCIGIDSGPVTAGVVGVSKWHYDVIGSVFDNALLMQSNATEPG-VYVSNETRRFLGS-TGEFEL 381

  Fly   427 EA--------GHGDERSSYLRDHGVDTFFIVPPPHRRKPLMLNTLGVRSAIGSRRKLSFRNVSNV 483
            |.        ||                  :|.|              ......::.|...|...
Worm   382 EKCPIGWKLYGH------------------LPSP--------------ELFPVNKRFSLVTVPQA 414

  Fly   484 VMQLLHTIKFSEPVPFSNIATGSFPSAASALGGGVSVGGGGGGGGGGVARGSTCEANSGNVQVSE 548
            |.::|.:|                                       ||...|.:
Worm   415 VNRVLQSI---------------------------------------VAMNPTLK---------- 430

  Fly   549 KGSRKVIRLQKILHATPPPHGMGYGSVVGSGGGVDSGISGGGGCVSGGIAGGGGVQVTVGTNPNS 613
                                                                     |:|||
Worm   431 ---------------------------------------------------------TMGTN--- 435

  Fly   614 TASTISRIHRHNHKNNKSQSKVADKFKRPFRKRHSVAAHHQPTNRVNRFLSQAINARSVDCDKSE 678
                      ...|..|||.|. |..|:                                  |.|
Worm   436 ----------KKRKGEKSQEKF-DMQKK----------------------------------KVE 455

  Fly   679 H---VDRLTLRFRQSDMEREYHKDFDLGFTTAMGCSLLLLILGAALQVTALPRTLILLLLFLFAF 740
            |   :..|:.|||...:|.||||:.|..|..::..|:..|::.....:..:||.:..|.|.:.|.
Worm   456 HSTIISTLSQRFRNPGLEAEYHKETDHWFIPSLAISIFFLVVYGIYHMLVMPRLITSLALIVGAL 520

  Fly   741 IWVSAILMLLLAVRLKWIIWDISESFSLRMAIT--------IFTVILIYSVGQVNVFTCVSDHPC 797
            ..:..||::|..        |...:||..:..|        |..:::::..|.||.|:|.
Worm   521 TVMFFILLMLYI--------DYFHTFSQFITRTSAGHAVSIILIIVILFVCGIVNTFSCP----- 572

  Fly   798 SGNGTTSFQNDSHRKCSLPQYVSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQN 862
                    |.::...|....:.:.|.|...::.:||:|.|.::.::|::.....|||.|.::..:
Worm   573 --------QPNAPDVCQKAHFSTYSFAMWTITTAVFVRFPSVYLAILLIISLLTYGLQIYVTRPD 629

  Fly   863 IFECYDNRVNASIPLHLISLARIAIFMIAILVHGRLVEGTARLDFLWQLQASQEKKEMDVLQESN 927
            .|...:......:...||||..:      :.:|.|..|...|||||..::..:|....|.|...|
Worm   630 EFGPREFMTELDLSCFLISLVSM------VFLHSRRCERLLRLDFLAVVKGIEETSMKDKLINLN 688

  Fly   928 KRILHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGLECLRLL 992
            .::|.||:|||||...:    :...:::|.|:..||:.:.:|..|     :::| :.|:..   |
Worm   689 NQMLLNLVPAHVAPGVI----QKAGDVWHHSHQSVGIAYIAVSGF-----DLEG-EAGING---L 740

  Fly   993 NEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEYKIQPND-PNSVRRHMTALIEYVKAMR 1056
            |.:.:.||:.:.  .::|::|:|:....|:..|||:|:.....|: |.::...|:.|..::.::.
Worm   741 NYVFSHFDQAIA--NYKGVEKVKSANRFYIVAVGLLPDAAQNVNETPWTIGELMSTLAHFIISIS 803

  Fly  1057 HSLQEINSHSYNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYSQVTQEV 1121
            ....|      |.|.:::|::.|..:|.|....:|:|:|:|.|::.:..:........:.|::||
Worm   804 QFAME------NEFHVQIGVDCGSTLAFVANTDQPRYEIFGETLDRSRTLMQAAGHDTTLVSEEV 862

  Fly  1122 VDSLVGSHFEFRCRGTIKVKGKGDMVTYFLCDSGNKSLNGEVRNAMSLPQSLHAPDYYMKVSQFP 1186
            ..:|......|..:   .||...::..|.|. :|.:.::.::.......|..|...  |..:||.
Worm   863 FLALRPRPLRFSSQ---PVKVAMNLNAYELV-TGLRDVSVDIPTMPREEQERHTQG--MVEAQFA 921

  Fly  1187 ENRVNTDTYS---------------KKENGHLYAGNGVE----EQQLLL----QHQHK------Q 1222
            ......||.:               :..:|.....:.:|    |..|:.    |..|:      .
Worm   922 NQSRMYDTQTSEMASSMASSFSSELRSIDGDAETDSDLEWITPETALMKDPQPQRSHRFVLKNSD 986

  Fly  1223 HDPLPLPAPPPPVHHHLH--QQQQQRLNSKLQ 1252
            :||.     ..|||.::.  ..:|...|.::|
Worm   987 YDPY-----REPVHRNIRAMSAEQDYRNRRIQ 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	47/211 (22%)
		CYCc	230..425	CDD:214485	62/200 (31%)
		Guanylate_cyc	266..438	CDD:278633	56/183 (31%)
		DUF1053	624..696	CDD:283888	15/74 (20%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	31/158 (20%)
		CYCc	924..1134	CDD:214485	50/210 (24%)
		Guanylate_cyc	954..1151	CDD:278633	44/197 (22%)
acy-3	NP_497765.4	TctB	26..137	CDD:284693	24/134 (18%)
		CYCc	195..378	CDD:214485	59/192 (31%)
		Nucleotidyl_cyc_III	221..382	CDD:299850	53/164 (32%)
		CYCc	696..873	CDD:214485	45/197 (23%)
		Nucleotidyl_cyc_III	711..880	CDD:299850	42/188 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I6081
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910