DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rut and Gucy2e

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	XP_036012232.1	Gene:	Gucy2e / 14919	MGIID:	105123	Length:	1139	Species:	Mus musculus

Alignment Length:	342	Identity:	94/342 - (27%)
Similarity:	158/342 - (46%)	Gaps:	88/342 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 PSVHISLTVYK---------IFTDALRYLEYNQLIANIVIFIGVNVAGLVVNIMMERAQRRTFLD 217
            ||:.::..::|         |....||.||  |..:|:            .:::.||.:
Mouse   830 PSMDLTFDLFKSINKGRKTNIIDSMLRMLE--QYSSNL------------EDLIRERTE------ 874

  Fly   218 TRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMK-NDILSPVAGQFHRIYIQKHENVSILFADI 281
                     |::.|.:|.:|||..:||..||..:| ...:.|          :..|.|::.|:||
Mouse   875 ---------ELEQEKQKTDRLLTQMLPPSVAEALKMGTSVEP----------EYFEEVTLYFSDI 920

  Fly   282 VGFTVLSSQCSAQELVRLLNELFGRFDQL--AHDNHCLRIKILGDCYYCVSGLPEPR-KDHAKCA 343
            ||||.:|:.....|:|.|||:|:..||.:  |||.:  :::.:||.|...||||:.. :.||...
Mouse   921 VGFTTISAMSEPIEVVDLLNDLYTLFDAIIGAHDVY--KVETIGDAYMVASGLPQRNGQRHAAEI 983

  Fly   344 VEMGLDMIDAIAT--VVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDVTLANHMESGGE 406
            ..|.||::.|:.:  :....:|.:.:|:|:|:|..:.||:||...::.::.:.|..|:.|||.|.
Mouse   984 ANMSLDILSAVGSFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGL 1048

  Fly   407 PGRVHVTRAT---LDSLSGEYEVEA-------GHGDERSSYL--------------------RDH 441
            |.|:||..:|   |.:|...:::|.       |.|.|.:.:|                    .:|
Mouse  1049 PYRIHVNMSTVRILRALDQGFQMECRGRTELKGKGIEDTYWLVGRLGFNKPIPKPPDLQPGASNH 1113

  Fly   442 GVDTFFIVPPPHRRKPL 458
            |:....|  ||.|||.|
Mouse  1114 GISLQEI--PPERRKKL 1128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	23/102 (23%)
		CYCc	230..425	CDD:214485	67/203 (33%)
		Guanylate_cyc	266..438	CDD:278633	60/186 (32%)
		DUF1053	624..696	CDD:283888
		SLC5-6-like_sbd	<742..>893	CDD:294310
		CYCc	924..1134	CDD:214485
		Guanylate_cyc	954..1151	CDD:278633
Gucy2e	XP_036012232.1	PBP1_sensory_GC_DEF-like	58..465	CDD:380594
		PK_GC-2D	570..845	CDD:270945	3/14 (21%)
		HNOBA	<854..899	CDD:400168	18/73 (25%)
		CYCc	879..1070	CDD:214485	67/202 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810