DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rut and LRRK2

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_940980.4	Gene:	LRRK2 / 120892	HGNCID:	18618	Length:	2527	Species:	Homo sapiens

Alignment Length:	972	Identity:	176/972 - (18%)
Similarity:	312/972 - (32%)	Gaps:	307/972 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   798 SGNGTTSFQNDSHRKCSLPQYVSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQN 862
            |.|..:|...:....|  |:..|.||...||:.     :|.:..|:.:|.:.           ||
Human  1137 SKNHISSLSENFLEAC--PKVESFSARMNFLAA-----MPFLPPSMTILKLS-----------QN 1183

  Fly   863 IFECYDNRVNASIPLHLISL--------------------ARIAIF---MIAILVHGRLVEGTAR 904
            .|.|....: .::| ||.||                    .|..:|   .|:||       ..:.
Human  1184 KFSCIPEAI-LNLP-HLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISIL-------DLSE 1239

  Fly   905 LDFLW----QLQASQEKKEMDVLQESNKRI--LHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVG 963
            ..:||    :|..|..|     |:|....|  |.||..       ||..:...:..:.....|:.
Human  1240 KAYLWSRVEKLHLSHNK-----LKEIPPEIGCLENLTS-------LDVSYNLELRSFPNEMGKLS 1292

  Fly   964 VIFASVPNFNEFYTEMDGSDQGLECLRLLNEIIADFDELLKEDRFRGIDKIKTVGST-------- 1020
            .|: .:| .:|.:...|....|.:.    .:||....:.||:.......|:..||:|
Human  1293 KIW-DLP-LDELHLNFDFKHIGCKA----KDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLL 1351

  Fly  1021 -------------YMAVVGL-IPEYKIQPNDPNSVRRHMTALIEYVKAMRHSLQEINSHSYNNFM 1071
                         ..|.||: :.::.||..|.   |:....|..:..|.|......:.|......
Human  1352 QQLMKTKKSDLGMQSATVGIDVKDWPIQIRDK---RKRDLVLNVWDFAGREEFYSTHPHFMTQRA 1413

  Fly  1072 LRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGV----------------PGYSQVTQE 1120
            |.:.:.........:.|.||    |  ..|:.:|..|:.|                ...|::|:|
Human  1414 LYLAVYDLSKGQAEVDAMKP----W--LFNIKARASSSPVILVGTHLDVSDEKQRKACMSKITKE 1472

  Fly  1121 VVD-----SLVGSHFEFRCRGTIKVKGKGDMVTYFLCDSGNKSLNGEVRNAMSLPQSLHAPDYYM 1180
            :::     ::...||       :....:.|.:........|:|||.::|:.:.:.|.:  ||.|:
Human  1473 LLNKRGFPAIRDYHF-------VNATEESDALAKLRKTIINESLNFKIRDQLVVGQLI--PDCYV 1528

  Fly  1181 KVS------------QFP------------ENRVNTDTYSKKENGHLYAGNGVEEQQLLLQHQHK 1221
            ::.            :||            ||::..|     ||...:|.:.:.|..:||   |.
Human  1529 ELEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLD-----ENELPHAVHFLNESGVLL---HF 1585

  Fly  1222 QHDPLPLPAPPPPVHHHLHQQQQQRLNSKLQKQPIFMANGGLPNIRENGNGHNGEHQQQQQQQQQ 1286
            |...|.|        ..|:..:.:.| .|:..|.:.:...|.|           :|.:....::.
Human  1586 QDPALQL--------SDLYFVEPKWL-CKIMAQILTVKVEGCP-----------KHPKGIISRRD 1630

  Fly  1287 HQQQQQQQQQHGGFMVATTTPPAAVAVPLQPQHHQLQ-------FQHPHQHPLPSAVSVPVQHQI 1344
            .::...::::.                   |:::..|       ||          :::|:..:.
Human  1631 VEKFLSKKRKF-------------------PKNYMSQYFKLLEKFQ----------IALPIGEEY 1666

  Fly  1345 LLHHQLQLQHQPVPSVMLREFNIIENPTSGGRHQQMEQLPPHHGSLDLSGMGMGVGAGVLGS--- 1406
            ||.......|:||     .|....||.....|..:|...|            ||..:.::..
Human  1667 LLVPSSLSDHRPV-----IELPHCENSEIIIRLYEMPYFP------------MGFWSRLINRLLE 1714

  Fly  1407 -DCFMMPRRDRERTYVPPLNQHGHHPPHHLH--SNLNLNQS-------------QHPPSFTSLGY 1455
             ..:|:..|:|...            |:.::  ..:.||.|             .||.||..:..
Human  1715 ISPYMLSGRERALR------------PNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFLKITV 1767

  Fly  1456 GQCRESEPLLHASSVAPVAKIMPMQHAPKYEPPRYTSPHTMLSQQHQQQQQQQHQHQQPQSQSAQ 1520
            ..||:...|| ...|..:..:|........|........|:|.:..........:||    :...
Human  1768 PSCRKGCILL-GQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQ----KILL 1827

  Fly  1521 DQQTHPAQDPHPLQRQYAMYSQQPQLPPKPVLRTYMKPLPKLPTDL---EESRDMSSTDDLSSRP 1582
            |.....|::...|     :...||:|         ..|:.::..||   :..|::...:|.....
Human  1828 DDLMKKAEEGDLL-----VNPDQPRL---------TIPISQIAPDLILADLPRNIMLNNDELEFE 1878

  Fly  1583 HSPSMSSSDESYSKTTEGEGEGDEDSPRMVNGG--------------HLHHRNGYHLPAGGL 1630
            .:|.....|.|:........||:|.:.::.|..              ||||.:...|.|.|:
Human  1879 QAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGI 1940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831
		CYCc	230..425	CDD:214485
		Guanylate_cyc	266..438	CDD:278633
		DUF1053	624..696	CDD:283888
		SLC5-6-like_sbd	<742..>893	CDD:294310	25/117 (21%)
		CYCc	924..1134	CDD:214485	46/254 (18%)
		Guanylate_cyc	954..1151	CDD:278633	40/239 (17%)
LRRK2	NP_940980.4	Required for RAB29-mediated activation. /evidence=ECO:0000269\|PubMed:29212815	1..969
		LRR 1	983..1004
		leucine-rich repeat	985..1012	CDD:275380
		LRR	1012..>1286	CDD:227223	40/187 (21%)
		LRR 2	1012..1033
		leucine-rich repeat	1013..1036	CDD:275380
		LRR 3	1036..1057
		leucine-rich repeat	1037..1084	CDD:275380
		LRR 4	1059..1080
		LRR 5	1084..1105
		leucine-rich repeat	1085..1108	CDD:275380
		LRR 6	1108..1129
		leucine-rich repeat	1109..1130	CDD:275380
		LRR 7	1130..1150		3/12 (25%)
		leucine-rich repeat	1131..1174	CDD:275380	11/43 (26%)
		LRR 8	1174..1196		6/33 (18%)
		leucine-rich repeat	1175..1197	CDD:275380	6/34 (18%)
		LRR 9	1197..1218		4/20 (20%)
		leucine-rich repeat	1198..1221	CDD:275380	3/22 (14%)
		LRR 10	1221..1241		5/26 (19%)
		leucine-rich repeat	1222..1246	CDD:275380	7/30 (23%)
		LRR 11	1246..1267		6/25 (24%)
		leucine-rich repeat	1247..1269	CDD:275380	7/26 (27%)
		LRR 12	1269..1291		4/28 (14%)
		RocCOR	1334..1507	CDD:206741	30/188 (16%)
		COR	1527..1740	CDD:318343	45/298 (15%)
		STKc_LRRK2	1884..2135	CDD:270970	13/57 (23%)
		WD 1	2139..2183
		WD 2	2188..2228
		WD 3	2233..2276
		WD 4	2281..2327
		WD 5	2333..2377
		WD 6	2402..2438
		WD 7	2443..2497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900