DRSC/TRiP Functional Genomics Resources

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Protein Alignment rut and Adcy8

DIOPT Version :10

Sequence 1:NP_511156.2 Gene:rut / 32406 FlyBaseID:FBgn0003301 Length:2248 Species:Drosophila melanogaster
Sequence 2:NP_033753.2 Gene:Adcy8 / 11514 MGIID:1341110 Length:1249 Species:Mus musculus


Alignment Length:1274 Identity:473/1274 - (37%)
Similarity:679/1274 - (53%) Gaps:233/1274 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 RGRPLNTLR--FENDELECLYQRYTLKLQRFS--VLGVVALVFVLCGVMAALSLTFNNAATFHNI 69
            ||....|||  |::.:||.|||||.|..:|.|  |:.|:.::..|..::..|||    |:...:.
Mouse   148 RGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSL----ASAPMDP 208

  Fly    70 FNAIVCGLFAVVLVLLQCSVI---KDHHLPT-LCY-GILLFTASICVVSMPTLGSVFPVDTKEVM 129
            ...|:.|.|..:.|:: |:::   ||:...| |.| |::.:.|....:....||       ..::
Mouse   209 LKGILLGFFTGIEVVI-CALVVVRKDNTSHTYLQYSGVVTWVAMTTQILAAGLG-------YGLL 265

  Fly   130 AEGVWQIVFVVFLAYAMMPLQIWEAVAFGIALPSVHISLTVYKIFTDALRYLEYNQLIANIVIFI 194
            .:|:..::|.:|..|:|:||.:..|:..|:....:.::|   ::....|.....||::|.:|:|:
Mouse   266 GDGIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQVTL---QVLIPRLAVFSINQVLAQVVLFM 327

  Fly   195 GVNVAGLVVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDILS-- 257
            .:|.||:.::.:.:||||:.||:||.|:.:||.::.||::.|||:|||||:.|.::|.||:.:  
Mouse   328 CMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVE 392

  Fly   258 --PVAGQFHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIK 320
              .:..|||||||.::|||||||||:.|||.||:..|||||||:|||||.|||:|||::||||||
Mouse   393 DEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIK 457

  Fly   321 ILGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRK 385
            ||||||||||||||||:|||.|.|||||.||..|..|...|...::||:|||:|.||||||||||
Mouse   458 ILGDCYYCVSGLPEPRRDHAHCCVEMGLSMIKTIRFVRSRTKHDVDMRIGIHSGSVLCGVLGLRK 522

  Fly   386 WQFDVWSNDVTLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFFIVP 450
            |||||||.||.:||.:||||.|||:|:::||||.|:|:|.||.|||.||:.:||.|.::|:.|..
Mouse   523 WQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQ 587

  Fly   451 PPHRRKPLMLNTLGVRSAIGSRRK--LSFRNVSNVVMQLLHTIKFSEPVPFSNIATGSFPSAASA 513
            |......|..:.:....:...||.  .:|...|           :|..:||.||           
Mouse   588 PEESLLCLPEDIVKESVSCSDRRNSGATFTEGS-----------WSPELPFDNI----------- 630

  Fly   514 LGGGVSVGGGGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYGSVVGS 578
                             |.:.:|..|.:.|                                   
Mouse   631 -----------------VGKQNTLAALTRN----------------------------------- 643

  Fly   579 GGGVDSGISGGGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRHNHKNNKSQSKVADKFKRPF 643
                                       ::...||..|.                           
Mouse   644 ---------------------------SINLLPNHLAQ--------------------------- 654

  Fly   644 RKRHSVAAHHQP-TNRVNRFLSQAINARSVDCDKSEHVDRLTLRFRQSDMEREYHKDFDLGFTTA 707
                  |.|.|. ...:|:.:...|:.||.|..:.||:...:|.|:.|.:|.:|.:..|..|.:.
Mouse   655 ------ALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSN 713

  Fly   708 MGCSLLLLILGAALQVTALPRTLILLLLFLFAFIWV--SAILMLLLA--------VRLKWIIWDI 762
            :.|:.::|:...|:| :.||.:.::.:...|:.:.:  ||::::..|        :..|...| |
Mouse   714 LVCAFIVLLFITAIQ-SLLPSSRLMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCW-I 776

  Fly   763 SESFSLRMAITIFTVILIYSVGQV-NVFTCVSDH--PCSG---NGTTSFQNDSHRKCSLPQYVSL 821
            :|::..|..| ||..|||..:|.| |:..|..|.  |...   |.:..|.:    .||.|:|...
Mouse   777 NETYLARNVI-IFASILINFLGAVLNILWCDFDKSIPLKNLTFNSSAVFTD----ICSYPEYFVF 836

  Fly   822 SAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQNIFECYDNRVNAS----IPLHLISL 882
            :...|.::.:|||||..:.|..::|.|..||.|..|..:..:|..||| :|.|    :.....||
Mouse   837 TGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETIYAGLFLSYDN-LNHSGEDFLGTKEASL 900

  Fly   883 ARIAIFMIAILVHGRLVEGTARLDFLWQLQASQEKKEMDVLQESNKRILHNLLPAHVAAHFLDAQ 947
            ..:|:|::|:..||:.:|.||||||||::||.:|..||..|:|.|:.:|.|:||:|||.|||:..
Mouse   901 LLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKD 965

  Fly   948 FRNNMELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGLECLRLLNEIIADFDELLKEDRFRGID 1012
             |:|.|||.|||..|||:|||:|.|.:||::.:.::||:|||||||||||||||||.||||:.|:
Mouse   966 -RDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIE 1029

  Fly  1013 KIKTVGSTYMAVVGLIPEYKIQPNDPNSVRRHMTALIEYVKAMRHSLQEINSHSYNNFMLRVGIN 1077
            ||||:|||||||.||.|| |.|..|...   |:.||.::..|:..|:||||.||:|||.||:||:
Mouse  1030 KIKTIGSTYMAVSGLSPE-KQQCEDKWG---HLCALADFSLALTESIQEINKHSFNNFELRIGIS 1090

  Fly  1078 IGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYSQVTQEVVDSLVGSHFEFRCRGTIKVKG 1142
            .|.||||||||:||||||||.|||:|||||||||.|..||.:|....|....|.|..||.|.|||
Mouse  1091 HGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKG 1155

  Fly  1143 ----KGDMVTYFLCDSGNKSLNGEVR-NAMSLPQSLHAPDYYMKVSQFPENRVNTDTYSKKENGH 1202
                :|.:.||||.        |.|: |...||.. ..|..|              :.:....|.
Mouse  1156 ISEQEGKIKTYFLL--------GRVQPNPFILPPR-RLPGQY--------------SLAAVVLGL 1197

  Fly  1203 LYAGNGVEEQQLLLQH-------QHKQHDPLPLPAPPPP 1234
            :.:.|...::|||.::       .|.....|..|:.|.|
Mouse  1198 VQSLNRQRQKQLLNENSNSGIIKSHYNRRTLLTPSGPEP 1236

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rutNP_511156.2 AC_N <17..255 CDD:318454 76/246 (31%)
Guanylate_cyc 266..428 CDD:425528 114/161 (71%)
Adcy_cons_dom 624..698 CDD:461877 15/74 (20%)
AcyC 742..1150 CDD:441717 201/431 (47%)
Guanylate_cyc 954..1151 CDD:425528 120/200 (60%)
Adcy8NP_033753.2 Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..180 15/31 (48%)
Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..107
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 14..33
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 38..40
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 49..51
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 50..118
AcyC 212..565 CDD:441717 176/363 (48%)
Guanylate_cyc 403..587 CDD:425528 125/183 (68%)
Adcy_cons_dom 615..710 CDD:461877 30/228 (13%)
Guanylate_cyc 971..1170 CDD:425528 122/210 (58%)
Involved in CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 1107..1249 51/153 (33%)
Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250|UniProtKB:P40146 1198..1213 4/14 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1221..1249 5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

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