DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rut and Adcy7

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	XP_006530643.1	Gene:	Adcy7 / 11513	MGIID:	102891	Length:	1146	Species:	Mus musculus

Alignment Length:	1279	Identity:	426/1279 - (33%)
Similarity:	607/1279 - (47%)	Gaps:	267/1279 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ENDELECLYQRYTLKLQRFSVLGVVALVFVLCGVMAALSLTFNNAATFHNIF--NAIVCG----- 76
            |..:...||::|.|.    |:.|.:.|:.:|  |.||..:...:.|..|...  :.:|.|
Mouse    14 EGPDQAALYEKYRLT----SLHGPLLLLLLL--VAAATCIALISIAFSHEDLRRHQVVLGTAFLM 72

  Fly    77 --LFAVVLVLLQCSVIKDHHLPTLCYGILLFTASICVVSMPTLGSVFPVDTKEVMAEGVWQ---- 135
              ||..:.||:....:....|..|.   ||..|.:.|     ||||...|:.|..|. .|:
Mouse    73 LTLFVALYVLVYVECLVQRWLRALA---LLTWACLMV-----LGSVLMWDSLENEAH-AWEQVPF 128

  Fly   136 IVFVVFLAYAMMPLQIWEAVAFGIALPSVHISL--TVYKIFTDALRYLEYN-QLIANIVIFIGVN 197
            .:||||:.||::||....|:..|:.....|:.:  .|.:.|..::...:.. ||:||.||.:|.|
Mouse   129 FLFVVFVVYALLPLSRRAAIVAGVTSTVSHLLVFGAVTRAFQTSMSSTQLGLQLLANAVILLGGN 193

  Fly   198 VAGLVVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDILSPVA-- 260
            ..|......::.|.|..|:.|..||..|.:::.|..:.|.|||||||.|::|.||..|:..:.
Mouse   194 FTGAFHKHQLQDASRDLFIYTVKCIQIRRKLRVEKRQQENLLLSVLPAHISMGMKLAIIERLKEG 258

  Fly   261 --------GQFHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCL 317
                    ..||.:|:::|:|||||:|||||||.|:|.||.:|||.:||||||:|||:|..|.|:
Mouse   259 GDRHYMPDNNFHSLYVKRHQNVSILYADIVGFTRLASDCSPKELVVVLNELFGKFDQIAKANECM 323

  Fly   318 RIKILGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLG 382
            ||||||||||||||||.....||:..|:||||:.:||..|.|||.|.::||||||:|.|||||:|
Mouse   324 RIKILGDCYYCVSGLPVSLPTHARNCVKMGLDICEAIKQVREATGVDISMRVGIHSGNVLCGVIG 388

  Fly   383 LRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFF 447
            |||||:||||:||:|||.||:.|.|||||:|.|||:.|...||||.|||::|..||::..:.|:.
Mouse   389 LRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLNHLDKAYEVEDGHGEQRDPYLKEMNIRTYL 453

  Fly   448 IV-------PPP--HRRKPLMLNTLGVRSAIGSRRKLSFRNVSNVVMQLLH--TIKFSEPVPFSN 501
            ::       |||  |..||....||.:|:::...|.|.....:.....|.|  ::..|| .|.||
Mouse   454 VIDPRSQQPPPPSHHLSKPKGDATLKMRASVRVTRYLESWGAARPFAHLNHRESVSSSE-TPISN 517

  Fly   502 IATGSFPSAASALGGGVSVGGGGGGGGGGVARGSTCEANSGNVQVSEKGSR-KVIRLQKILHATP 565
                                                            |.| |.|.|::
Mouse   518 ------------------------------------------------GRRQKAIPLRR------ 528

  Fly   566 PPHGMGYGSVVGSGGGVDSGISGGGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRHNHKNNK 630
                                                                    ||...::..
Mouse   529 --------------------------------------------------------HRAPDRSAS 537

  Fly   631 SQSKVADKFKRPFRKRHSVAAHHQPTNRVNRFLS--QAINARSVDCDKSEHVDRLTLRFRQSDME 693
            .:.::.|...                   :..||  :.:::....|.||:........|.:...|
Mouse   538 PKGRLEDDCD-------------------DEMLSAIEGLSSTRPCCSKSDDFHTFGPIFLEKGFE 583

  Fly   694 REY--------HKDFDLGFTTAMGCSLLLLILGAALQVTALPRTLILLLLFLFAFIWVSAILMLL 750
            |||        ..||        .|:.|:.:....:.:..:||...|.:.|......:..:|...
Mouse   584 REYRLVPIPRARYDF--------ACASLVFVCILLVHLLVMPRMATLGVSFGLVACLLGLVLSFC 640

  Fly   751 LAVRL------KWIIWDISESFS----LRMAITIFTVILIYSVGQVNVFTCVSDHP-CSGNGTTS 804
            .|...      :..:..||||..    :|:.:.:.||..:.:|..:|:...::..| ..|:..||
Mouse   641 FATEFSRCFPSRSTLQAISESVETQPLVRLVLVVLTVGSLLTVAIINMPLTLNPGPEQPGDNKTS 705

  Fly   805 ---FQNDSHRKCSLPQYVSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQNIFEC 866
               .||.....|.|..|.:.|....|::.|||||:.:..|::|:......|.|...||     .|
Mouse   706 PLAAQNRVGTPCELLPYYTCSCILGFIACSVFLRMSLELKAMLLTVALVAYLLLFNLS-----PC 765

  Fly   867 YDNRVNA-----------------SIPLHLIS------------LAR---------IAIFMIAIL 893
            :....|:                 |:|.|.::            |.|         :.:|...::
Mouse   766 WHVSGNSTETNGTQRTRLLLSDAQSMPSHTLAPGARETAPSPSYLERDLKIMVNFYLILFYATLI 830

  Fly   894 VHGRLVEGTARLDFLWQLQASQEKKEMDVLQESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQS 958
            :..|.::...|||.||:.:..:|.:|.:.::..|:.:|.|:|||||||||:..:...  :.||||
Mouse   831 LLSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKAAE--DWYHQS 893

  Fly   959 YAKVGVIFASVPNFNEFYTEMDGSDQGLECLRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMA 1023
            |..|.|:|||||:|..||||.|.:.:|||||||||||||||||||.:.:|.|::||||:||||||
Mouse   894 YDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMA 958

  Fly  1024 VVGLIPEYKIQPNDPNSVRRHMTALIEYVKAMRHSLQEINSHSYNNFMLRVGINIGPVVAGVIGA 1088
            ..||......:..|......|:..|:|:..|:...|..||.||:|:|.||||||.|||:||||||
Mouse   959 AAGLSAPSGHENQDLERKHVHIGVLVEFSMALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGA 1023

  Fly  1089 RKPQYDIWGNTVNVASRMDSTGVPGYSQVTQEVVDSLVGSHFEFRCRGTIKVKGKGDMVTY---- 1149
            ||||||||||||||||||:|||..|..|||:|....|.|..:...|||.|.|||||::.||
Mouse  1024 RKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFELF 1088

  Fly  1150 FLCDS-GNKSLNGEVRNAMSLPQSLHAPDYYMKVSQFPENRVNT 1192
            ||..| |...::|.:....||....:.|...:|.  .|:..:.|
Mouse  1089 FLNPSVGQGFVSGSLLRRPSLTTDSNTPSSDLKT--LPDKVIVT 1130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	76/251 (30%)
		CYCc	230..425	CDD:214485	119/204 (58%)
		Guanylate_cyc	266..438	CDD:278633	111/171 (65%)
		DUF1053	624..696	CDD:283888	9/73 (12%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	41/202 (20%)
		CYCc	924..1134	CDD:214485	118/209 (56%)
		Guanylate_cyc	954..1151	CDD:278633	117/200 (59%)
Adcy7	XP_006530643.1	AC_N	<75..251	CDD:318454	60/184 (33%)
		Guanylate_cyc	272..422	CDD:306677	99/149 (66%)
		DUF1053	487..593	CDD:399378	27/235 (11%)
		Guanylate_cyc	890..1085	CDD:306677	116/194 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710