DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rut and ADCY8

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_001106.1	Gene:	ADCY8 / 114	HGNCID:	239	Length:	1251	Species:	Homo sapiens

Alignment Length:	1207	Identity:	459/1207 - (38%)
Similarity:	658/1207 - (54%)	Gaps:	219/1207 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RGRPLNTLR--FENDELECLYQRYTLKLQRFS--VLGVVALVFVLCGVMAALSLTFNNAATFHNI 69
            ||....|||  |::.:||.|||||.|..:|.|  |:.|:.::..|..::..|||    |:...:.
Human   150 RGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSL----ASAPMDP 210

  Fly    70 FNAIVCGLFAVVLVLLQCSVI---KDHHLPTLCYGILLFTASICVVSMPT------LGSVFPVDT 125
            ...|:.|.|..:.|:: |:::   ||    |..:..|.::..:..|:|.|      ||
Human   211 LKGILLGFFTGIEVVI-CALVVVRKD----TTSHTYLQYSGVVTWVAMTTQILAAGLG------- 263

  Fly   126 KEVMAEGVWQIVFVVFLAYAMMPLQIWEAVAFGIALPSVHISLTVYKIFTDALRYLEYNQLIANI 190
            ..::.:|:..::|.:|..|:|:||.:..|:..|:....:.:   :.::....|..:..||::|..
Human   264 YGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQV---ILQVVIPRLAVISINQVVAQA 325

  Fly   191 VIFIGVNVAGLVVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDI 255
            |:|:.:|.||:.::.:.:||||:.||:||.|:.:||.::.||::.|||:|||||:.|.::|.||:
Human   326 VLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDM 390

  Fly   256 LS----PVAGQFHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHC 316
            .:    .:..|||||||.::|||||||||:.|||.||:..|||||||:|||||.|||:|||::||
Human   391 TNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHC 455

  Fly   317 LRIKILGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVL 381
            ||||||||||||||||||||:|||.|.|||||.||..|..|...|...::||:|||:|.||||||
Human   456 LRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVL 520

  Fly   382 GLRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTF 446
            |||||||||||.||.:||.:||||.|||:|:::||||.|:|:|.||.|||.||:.:||.|.::|:
Human   521 GLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETY 585

  Fly   447 FIVPPPHRRKPLMLNTLGVRSAIGSRRK--LSFRNVSNVVMQLLHTIKFSEPVPFSNIATGSFPS 509
            .|..|......|..:.:....:...||.  .:|...|           :|..:||.||
Human   586 LIKQPEDSLLSLPEDIVKESVSSSDRRNSGATFTEGS-----------WSPELPFDNI------- 632

  Fly   510 AASALGGGVSVGGGGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYGS 574
                                 |.:.:|..|.:.|
Human   633 ---------------------VGKQNTLAALTRN------------------------------- 645

  Fly   575 VVGSGGGVDSGISGGGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRHNHKNNKSQSKVADKF 639
                                           ::...||..|.
Human   646 -------------------------------SINLLPNHLAQ----------------------- 656

  Fly   640 KRPFRKRHSVAAHHQP-TNRVNRFLSQAINARSVDCDKSEHVDRLTLRFRQSDMEREYHKDFDLG 703
                      |.|.|. ...:|:.:...|:.||.|..:.||:...:|.|:.|.:|.:|.:..|..
Human   657 ----------ALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEV 711

  Fly   704 FTTAMGCSLLLLILGAALQVTALPRTLILLLLFLFAFIWV--SAILMLLLA--------VRLKWI 758
            |.:.:.|:.::|:...|:| :.||.:.::.:...|:.:.:  ||::::..|        :..|..
Human   712 FKSNLVCAFIVLLFITAIQ-SLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTC 775

  Fly   759 IWDISESFSLRMAITIFTVILIYSVGQV-NVFTCVSDH--PCSG---NGTTSFQNDSHRKCSLPQ 817
            .| |:|::..|..| ||..|||..:|.: |:..|..|.  |...   |.:..|.:    .||.|:
Human   776 CW-INETYLARNVI-IFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTD----ICSYPE 834

  Fly   818 YVSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQNIFECYDNRVNAS----IPLH 878
            |...:...|.::.:|||||..:.|..::|.|..||.|..|..:..:|..||| :|.|    :...
Human   835 YFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDN-LNHSGEDFLGTK 898

  Fly   879 LISLARIAIFMIAILVHGRLVEGTARLDFLWQLQASQEKKEMDVLQESNKRILHNLLPAHVAAHF 943
            .:||..:|:|::|:..||:.:|.||||||||::||.:|..||..|:|.|:.:|.|:||:|||.||
Human   899 EVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHF 963

  Fly   944 LDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGLECLRLLNEIIADFDELLKEDRF 1008
            |:.. |:|.|||.|||..|||:|||:|.|.:||::.:.::||:|||||||||||||||||.||||
Human   964 LEKD-RDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRF 1027

  Fly  1009 RGIDKIKTVGSTYMAVVGLIPEYKIQPNDPNSVRRHMTALIEYVKAMRHSLQEINSHSYNNFMLR 1073
            :.|:||||:|||||||.||.|| |.|..|...   |:.||.::..|:..|:||||.||:|||.||
Human  1028 QDIEKIKTIGSTYMAVSGLSPE-KQQCEDKWG---HLCALADFSLALTESIQEINKHSFNNFELR 1088

  Fly  1074 VGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYSQVTQEVVDSLVGSHFEFRCRGTI 1138
            :||:.|.||||||||:||||||||.|||:|||||||||.|..||.:|....|....|.|..||.|
Human  1089 IGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEI 1153

  Fly  1139 KVKG----KGDMVTYFLCDSGNKSLNGEVR-NAMSLP 1170
            .|||    :|.:.||||.        |.|: |...||
Human  1154 YVKGISEQEGKIKTYFLL--------GRVQPNPFILP 1182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	75/250 (30%)
		CYCc	230..425	CDD:214485	130/198 (66%)
		Guanylate_cyc	266..438	CDD:278633	120/171 (70%)
		DUF1053	624..696	CDD:283888	14/72 (19%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	49/170 (29%)
		CYCc	924..1134	CDD:214485	126/209 (60%)
		Guanylate_cyc	954..1151	CDD:278633	120/200 (60%)
ADCY8	NP_001106.1	Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1..182		15/31 (48%)
		Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1..109
		Essential for CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	38..40
		Essential for CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	49..51
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..92
		AC_N	<161..400	CDD:292831	75/257 (29%)
		CYCc	366..564	CDD:214485	130/197 (66%)
		Guanylate_cyc	405..589	CDD:278633	125/183 (68%)
		DUF1053	617..711	CDD:283888	30/227 (13%)
		CYCc	944..1148	CDD:214485	125/208 (60%)
		Guanylate_cyc	973..1172	CDD:278633	122/210 (58%)
		Involved in CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1109..1251		39/82 (48%)
		Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250\|UniProtKB:P40146	1200..1215
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1223..1251
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.710