DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rut and ADCY7

DIOPT Version :9

Sequence 1:NP_511156.2 Gene:rut / 32406 FlyBaseID:FBgn0003301 Length:2248 Species:Drosophila melanogaster
Sequence 2:XP_011521137.1 Gene:ADCY7 / 113 HGNCID:238 Length:1086 Species:Homo sapiens


Alignment Length:1230 Identity:413/1230 - (33%)
Similarity:578/1230 - (46%) Gaps:265/1230 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 ENDELECLYQRYTLKLQRFSVLGVVALV-FVLCGVMAALSLTFNNAATFHNIFNA--IVCGLFAV 80
            |..:.:.||::|.|..|...:|..:.|| ...|..:..::.:..:.:....|...  :|..:||.
Human    14 EGPDQDALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPSRHQAILGMAFLVLAVFAA 78

  Fly    81 VLVLLQCSVIKDHHLPTLCYGILLFTASICVVSMPTLGSVFPVD--TKEVMAEGVWQ----IVFV 139
            :.||:....:....|..|.   ||..|  |:|:   ||.|...|  ||...|   |:    .:|:
Human    79 LSVLMYVECLLRRWLRALA---LLTWA--CLVA---LGYVLVFDAWTKAACA---WEQVPFFLFI 132

  Fly   140 VFLAYAMMPLQIWEAVAF-----------------GIALPSVHISLTVYKIFTDALRYLEYNQLI 187
            ||:.|.::|..:..|||.                 |...|||.:.|                ||:
Human   133 VFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGL----------------QLL 181

  Fly   188 ANIVIFIGVNVAGLVVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMK 252
            ||.|||:..|:.|......|:.|.|..|..|..||..|.:::.|..:.|.|||||||.|::|.||
Human   182 ANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAHISMGMK 246

  Fly   253 NDILSPVA----------GQFHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRF 307
            ..|:..:.          ..||.:|:::|:|||||:|||||||.|:|.||.:|||.:||||||:|
Human   247 LAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKELVVVLNELFGKF 311

  Fly   308 DQLAHDNHCLRIKILGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIH 372
            ||:|..|.|:||||||||||||||||.....||:..|:|||||..||..|.|||.|.:|||||||
Human   312 DQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIH 376

  Fly   373 TGRVLCGVLGLRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSY 437
            :|.|||||:||||||:||||:||:|||.||:.|.|||||:|.|||..|...||||.|||.:|..|
Human   377 SGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLKHLDKAYEVEDGHGQQRDPY 441

  Fly   438 LRDHGVDTFFIV-------PPPHRRKPLMLNTLGVRSAIGSRRKLSFRNVSNVVMQLLHTIKFSE 495
            |::..:.|:.::       |||.:..|              |.|                     
Human   442 LKEMNIRTYLVIDPRSQQPPPPSQHLP--------------RPK--------------------- 471

  Fly   496 PVPFSNIATGSFPSAASALGGGVSVGGGGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKI 560
                                                          |:..:..:.|.::.|..:.
Human   472 ----------------------------------------------GDAALKMRASVRMTRYLES 490

  Fly   561 LHATPPPHGMGYGSVVGSGGGVDSGISGGGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRHN 625
            ..|..|...:.:...|.|                      |...|..|..|.|..      .||.
Human   491 WGAARPFAHLNHRESVSS----------------------GETHVPNGRRPKSVP------QRHR 527

  Fly   626 HKNNKSQSKVADKFKRPFRKRHSVAAHHQPTNRV------NRFLS--QAINARSVDCDKSEHVDR 682
            ...::|.|                     |..|.      :..||  :.:::....|.||:....
Human   528 RTPDRSMS---------------------PKGRSEDDSYDDEMLSAIEGLSSTRPCCSKSDDFYT 571

  Fly   683 LTLRFRQSDMEREY--------HKDFDLGFTTAMGCSLLLLILGAALQVTALPRTLILLLLFLFA 739
            ....|.:...||||        ..||        .|:.|:.:....:.|..:|||..|.:.|...
Human   572 FGSIFLEKGFEREYRLAPIPRARHDF--------ACASLIFVCILLVHVLLMPRTAALGVSFGLV 628

  Fly   740 FIWVSAILMLLLAVRL------KWIIWDISESFS----LRMAITIFTVILIYSVGQVNV----FT 790
            ...:..:|.|..|.:.      :..:..|||...    ||:.:.:.|:..:.:|..:|:    |.
Human   629 ACVLGLVLGLCFATKFSRCCPARGTLCTISERVETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQ 693

  Fly   791 CVSDHPCSGN--GTTSFQNDSHRKCSLPQYVSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYG 853
             |.:.|. ||  |..:..:.:...|....|.:.|....|::.|||||:.:..|.:|:......|.
Human   694 -VPELPV-GNETGLLAASSKTRALCEPLPYYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYL 756

  Fly   854 LFIELSHQNIFEC---------YDNRVNASIP------LHLISLARIAIFMIAILVHGRLVEGTA 903
            :...||....::|         ..|...:..|      |..::...:.:|.|.:|...|.::...
Human   757 VLFNLSPCWQWDCCGQGLGNLTKPNGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYC 821

  Fly   904 RLDFLWQLQASQEKKEMDVLQESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFAS 968
            |||.||:.:..:|.:|.:.::..|:.:|.|:|||||||||:..:.  |.:.|||||..|.|:|||
Human   822 RLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKL--NEDWYHQSYDCVCVMFAS 884

  Fly   969 VPNFNEFYTEMDGSDQGLECLRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEYKI 1033
            ||:|..||||.|.:.:|||||||||||||||||||.:.:|.|::||||:||||||..||......
Human   885 VPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGH 949

  Fly  1034 QPNDPNSVRRHMTALIEYVKAMRHSLQEINSHSYNNFMLRVGINIGPVVAGVIGARKPQYDIWGN 1098
            :..:......|:..::|:..|:...|..||.||:|:|.||||||.|||:||||||||||||||||
Human   950 ENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGN 1014

  Fly  1099 TVNVASRMDSTGVPGY------SQVTQEVVDSLVGSHFEFRCRGTIKVKGKGDMVTYFLC 1152
            ||||||||:|||..|.      .|||:|....|.|..:...|||.|.|||||::.|||:|
Human  1015 TVNVASRMESTGELGKIQVSLPFQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVC 1074

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rutNP_511156.2 AC_N <17..255 CDD:292831 74/261 (28%)
CYCc 230..425 CDD:214485 121/204 (59%)
Guanylate_cyc 266..438 CDD:278633 113/171 (66%)
DUF1053 624..696 CDD:283888 13/79 (16%)
SLC5-6-like_sbd <742..>893 CDD:294310 37/181 (20%)
CYCc 924..1134 CDD:214485 117/215 (54%)
Guanylate_cyc 954..1151 CDD:278633 115/202 (57%)
ADCY7XP_011521137.1 AC_N <73..249 CDD:292831 62/202 (31%)
CYCc 224..429 CDD:214485 121/204 (59%)
Guanylate_cyc 270..432 CDD:278633 108/161 (67%)
DUF1053 485..592 CDD:283888 26/155 (17%)
CYCc 848..1052 CDD:214485 116/205 (57%)
Guanylate_cyc 871..1073 CDD:278633 115/201 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100296
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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