DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rut and ADCY6

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_001377760.1	Gene:	ADCY6 / 112	HGNCID:	237	Length:	1168	Species:	Homo sapiens

Alignment Length:	1205	Identity:	458/1205 - (38%)
Similarity:	636/1205 - (52%)	Gaps:	242/1205 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 RFENDELECLYQRYTLKLQRFSVLGVVALVFVLCGVMAALSLTFNNAATFHNIFNAIVCGLFAVV 81
            :|.:.:||.|||||..::.:.|:..::|::.:|..|:.|...........:....|....||..:
Human   130 QFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAYVALLACAAALFVGL 194

  Fly    82 LVLLQCSVIKDHHLPTLCYGILLFTASICVVSMPTLGSVFPVDTKEVMAEGVWQIVFVVFLAYAM 146
            :|:......:...:..:.|.:|...|::.|      |.....|.:...| |:|..||.|::||.:
Human   195 MVVCNRHSFRQDSMWVVSYVVLGILAAVQV------GGALAADPRSPSA-GLWCPVFFVYIAYTL 252

  Fly   147 MPLQIWEAVAFGIALPSVHISLTVYKIFTDALRYLEYNQLIANIVIFIGVNVAGLVVNIMMERAQ 211
            :|:::..||..|:.|.::|:.|.......||..   :.||.||:::|:..||.|:..:...|.:|
Human   253 LPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFL---WKQLGANVLLFLCTNVIGICTHYPAEVSQ 314

  Fly   212 RRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDILSPVAG-QFHRIYIQKHENVS 275
            |:.|.:||..|.:||.:|.||.:.||||||||||||||:||.||.:.... .||:||||||:|||
Human   315 RQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVS 379

  Fly   276 ILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYYCVSGLPEPRKDHA 340
            ||||||.|||.|:|||:|||||..|||||.|||:||.:|||||||||||||||||||||.|.|||
Human   380 ILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHA 444

  Fly   341 KCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDVTLANHMESGG 405
            .|.||||:|||:||:.|.|.|.|.:|||||||:|||.|||||||||||||||||||||||||:||
Human   445 HCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGG 509

  Fly   406 EPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFFIVPPPHRRK--PLMLNTLGVRSA 468
            ..||:|:|||||..|:|:||||.|.|.||::||::..::||.|:....:||  ..||..| .|:.
Human   510 RAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRKEEKAMLAKL-QRTR 573

  Fly   469 IGSRRKLSFRNVSNVVMQLLHTIKFSEPVPFSNIATGSFPSAASALGGGVSVGGGGGGGGGGVAR 533
            ..|...|..|.|                           |..|
Human   574 ANSMEGLMPRWV---------------------------PDRA---------------------- 589

  Fly   534 GSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYGSVVGSGGGVDSGISGGGGCVSGGIA 598
                        .|.....|..|..                      |:|.
Human   590 ------------FSRTKDSKAFRQM----------------------GIDD-------------- 606

  Fly   599 GGGGVQVTVGTNPNSTASTISRIHRHNHKNNKSQSKVADKFKRPFRKRHSVAAHHQPTNRVNRFL 663
                                      :.|:|:......:                 |.:.|:.||
Human   607 --------------------------SSKDNRGTQDALN-----------------PEDEVDEFL 628

  Fly   664 SQAINARSVDCDKSEHVDRLTLRFRQSDMEREYHKDFDLGFTTAMGCSLLLLILGAALQVTALPR 728
            |:||:|||:|..:.:||.|..|.|::.|:|::|.:..|..|...:.|:||:......:|:...|.
Human   629 SRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPH 693

  Fly   729 TLILLLLFLFAFIWVSAILMLLLAV--------------RLKWIIWDISESFSLRMAITIFTVIL 779
            :.::|      .|:.|..|:||:.|              .|:.:...|..|.:...|:.||:|:|
Human   694 STLML------GIYASIFLLLLITVLICAVYSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLL 752

  Fly   780 IYSVGQVNVFTCVS--------------------------------DHP-CSGNGTTSFQNDSHR 811
            :::....|:|||..                                |.| |.|...|
Human   753 VFTSAIANMFTCNHTPIRSCAARMLNLTPADITACHLQQLNYSLGLDAPLCEGTMPT-------- 809

  Fly   812 KCSLPQYVSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELS-HQNIFECYDNRVN--- 872
             ||.|:|...:...:.|:.||||.:..|.|..::..:|.||.:.:.|. ...||:.||..:.
Human   810 -CSFPEYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHG 873

  Fly   873 ----------------ASIPLHLISLARIAIFMIAILVHGRLVEGTARLDFLWQLQASQEKKEMD 921
                            ..:.|..::...:.:|.:|:.:|.:.||.||||||||:|||:.||:||:
Human   874 LASSNETFDGLDCPAAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEME 938

  Fly   922 VLQESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGL 986
            .||..|:|:|||:||..|||||| |:.|.|.|||:||...|.|:|||:.||:|||.|::.:::|:
Human   939 ELQAYNRRLLHNILPKDVAAHFL-ARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGV 1002

  Fly   987 ECLRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEYKIQPNDPNSVRRHMTALIEY 1051
            |||||||||||||||::.|:|||.::||||:||||||..||......|..     |.|:|||.:|
Human  1003 ECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVG-----RSHITALADY 1062

  Fly  1052 VKAMRHSLQEINSHSYNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYSQ 1116
            ...:...::.||.||:|||.:::|:|:||||||||||||||||||||||||:|||||||||...|
Human  1063 AMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQ 1127

  Fly  1117 VTQEVVDSLVGSHFEFRCRGTIKVKGKGDMVTYFL 1151
            ||.::...|....::..|||.:||||||:|.||||
Human  1128 VTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFL 1162

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	76/237 (32%)
		CYCc	230..425	CDD:214485	145/195 (74%)
		Guanylate_cyc	266..438	CDD:278633	131/171 (77%)
		DUF1053	624..696	CDD:283888	20/71 (28%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	44/217 (20%)
		CYCc	924..1134	CDD:214485	118/209 (56%)
		Guanylate_cyc	954..1151	CDD:278633	112/196 (57%)
ADCY6	NP_001377760.1	AC_N	<16..368	CDD:318454	78/247 (32%)
		Guanylate_cyc	370..554	CDD:306677	136/183 (74%)
		DUF1053	582..668	CDD:399378	31/225 (14%)
		Guanylate_cyc	970..1164	CDD:306677	114/198 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.710