Protein Alignment rut and ADCY5

DIOPT Version :10

• Sequence 1: NP_511156.2
• Gene: rut / 32406
• FlyBaseID: FBgn0003301
• Length: 2248
• Species: Drosophila melanogaster
• Sequence 2: NP_001365188.1
• Gene: ADCY5 / 111
• HGNCID: 236
• Length: 1286
• Species: Homo sapiens
• Alignment Length: 1231
• Identity: 467/1231 - (37%)
• Similarity: 671/1231 - (54%)
• Gaps: 267/1231 - (21%)

  Fly    17 RFENDELECLYQRYTLKLQRFSVLGVVALVFVLCGVMAALSLTFNNAATFHNI-------FNAIV 74
            :|.:|:||.|||||..:|.:.|:..::|::.::|.||.|          ||..       :.|::
Human   220 KFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLA----------FHAARPPLQLPYLAVL 274

  Fly    75 CGLFAVVLVL-LQCSVIKDH--HLPTLCYGILLFTASICVVSMPTLGSVFPVDTKEVMAEGVWQI 136
            .....|:|:: :.|:....|  |:...||.::....::.||     |.:.|  .....:||:|..
Human   275 AAAVGVILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVV-----GLLLP--QPRSASEGIWWT 332

  Fly   137 VFVVFLAYAMMPLQIWEAVAFGIALPSVHISLTVYKIFTDALRYLEYNQLIANIVIFIGVNVAGL 201
            ||.::..|.::|:::..||..|:.|.::|:::.   :.|:|.......||::|::||...|:.|:
Human   333 VFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIA---LRTNAQDQFLLKQLVSNVLIFSCTNIVGV 394

  Fly   202 VVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDILSPVAG-QFHR 265
            ..:...|.:||:.|.:||.||.:||..|.||::.|||||||||:||||:||.||.:.... .||:
Human   395 CTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHK 459

  Fly   266 IYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYYCVS 330
            ||||||:|||||||||.|||.|:|||:|||||..|||||.|||:||.:|||||||||||||||||
Human   460 IYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVS 524

  Fly   331 GLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDV 395
            ||||.|.|||.|.||||:|||:||:.|.|.|.|.:|||||||:|||.||||||||||||||||||
Human   525 GLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDV 589

  Fly   396 TLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFFIVPPPHRRKPLML 460
            |||||||:||:.||:|:|:|||:.|:|:||||.|.|.||::||::|.::||.|:....:||.
Human   590 TLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKE--- 651

  Fly   461 NTLGVRSAIGSRRKLSFRNVSNVVMQLLHTIKFSEP-----VPFSNIATGSFPSAASALGGGVSV 520
                 ..|:          ::.:..|..::|..:.|     .||.|           .|||.
Human   652 -----EKAM----------IAKMNRQRTNSIGHNPPHWGAERPFYN-----------HLGGN--- 687

  Fly   521 GGGGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYGSVVGSGGGVDSG 585
                                    |||::..|                 ||:
Human   688 ------------------------QVSKEMKR-----------------MGF------------- 698

  Fly   586 ISGGGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRHNHKNNKSQSKVADKFKRPFRKRHSVA 650
                                                  .:.|:..:|...
Human   699 --------------------------------------EDPKDKNAQESA--------------- 710

  Fly   651 AHHQPTNRVNRFLSQAINARSVDCDKSEHVDRLTLRFRQSDMEREYHKDFDLGFTTAMGCSLLLL 715
               .|.:.|:.||.:||:|||:|..:||||.:..|.||:.|:|::|.|..|..|...:.|:.|:.
Human   711 ---NPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVF 772

  Fly   716 ILGAALQVTALPRTLIL--------LLLFLFAFIWVSAILMLLLAVRLKWIIWDISESFSLRMAI 772
            :....:|:|.:|.::.:        |||.|..|:.|....:.|....|:.:...|..|......:
Human   773 LFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLV 837

  Fly   773 TIFTVILIYSVGQVNVFTCVS---------DHPCSGNGTTS-----------------FQNDSHR 811
            .:||:.|::....||:|||.|         :|..|.:...:                 |......
Human   838 GVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWP 902

  Fly   812 KCSLPQYVSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQNIFECYDNRVNAS-- 874
            .|:.|:|.:.|...:.|:.||||::..|.|.:|:|.:..||.|.:|:....:|:..|..|.|:
Human   903 NCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAI 967

  Fly   875 -----------------------------------------IPLHLISLARIAIFMIAILVHGRL 898
                                                     :.|.:::...|::|::|:.:|.:.
Human   968 DFFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQSPEHATKVALKVVTPIIISVFVLALYLHAQQ 1032

  Fly   899 VEGTARLDFLWQLQASQEKKEMDVLQESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVG 963
            ||.||||||||:|||::||:||:.||..|:|:|||:||..|||||| |:.|.|.|||:||...|.
Human  1033 VESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFL-ARERRNDELYYQSCECVA 1096

  Fly   964 VIFASVPNFNEFYTEMDGSDQGLECLRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLI 1028
            |:|||:.||:|||.|::.:::|:|||||||||||||||::.|||||.::||||:||||||..||
Human  1097 VMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGL- 1160

  Fly  1029 PEYKIQPNDP--NSV-RRHMTALIEYVKAMRHSLQEINSHSYNNFMLRVGINIGPVVAGVIGARK 1090
                   ||.  :.| :.|:.||.::...:...::.||.||:|||.:::|:||||||||||||||
Human  1161 -------NDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARK 1218

  Fly  1091 PQYDIWGNTVNVASRMDSTGVPGYSQVTQEVVDSLVGSHFEFRCRGTIKVKGKGDMVTYFL 1151
            ||||||||||||||||||||||...|||.::...|..:.::..|||.:||||||:|:||||
Human  1219 PQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFL 1279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:318454	79/247 (32%)
		Guanylate_cyc	266..428	CDD:425528	125/161 (78%)
		Adcy_cons_dom	624..698	CDD:461877	22/73 (30%)
		AcyC	742..1150	CDD:441717	192/479 (40%)
		Guanylate_cyc	954..1151	CDD:425528	114/199 (57%)
ADCY5	NP_001365188.1	AC_N	1..458	CDD:318454	81/257 (32%)
		Guanylate_cyc	460..643	CDD:425528	135/182 (74%)
		Adcy_cons_dom	668..761	CDD:461877	37/216 (17%)
		Guanylate_cyc	1087..1281	CDD:425528	116/201 (58%)