DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rut and ADCY5

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_001365188.1	Gene:	ADCY5 / 111	HGNCID:	236	Length:	1286	Species:	Homo sapiens

Alignment Length:	1231	Identity:	467/1231 - (37%)
Similarity:	671/1231 - (54%)	Gaps:	267/1231 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 RFENDELECLYQRYTLKLQRFSVLGVVALVFVLCGVMAALSLTFNNAATFHNI-------FNAIV 74
            :|.:|:||.|||||..:|.:.|:..::|::.::|.||.|          ||..       :.|::
Human   220 KFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLA----------FHAARPPLQLPYLAVL 274

  Fly    75 CGLFAVVLVL-LQCSVIKDH--HLPTLCYGILLFTASICVVSMPTLGSVFPVDTKEVMAEGVWQI 136
            .....|:|:: :.|:....|  |:...||.::....::.||     |.:.|  .....:||:|..
Human   275 AAAVGVILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVV-----GLLLP--QPRSASEGIWWT 332

  Fly   137 VFVVFLAYAMMPLQIWEAVAFGIALPSVHISLTVYKIFTDALRYLEYNQLIANIVIFIGVNVAGL 201
            ||.::..|.::|:::..||..|:.|.::|:::.   :.|:|.......||::|::||...|:.|:
Human   333 VFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIA---LRTNAQDQFLLKQLVSNVLIFSCTNIVGV 394

  Fly   202 VVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDILSPVAG-QFHR 265
            ..:...|.:||:.|.:||.||.:||..|.||::.|||||||||:||||:||.||.:.... .||:
Human   395 CTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHK 459

  Fly   266 IYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYYCVS 330
            ||||||:|||||||||.|||.|:|||:|||||..|||||.|||:||.:|||||||||||||||||
Human   460 IYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVS 524

  Fly   331 GLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDV 395
            ||||.|.|||.|.||||:|||:||:.|.|.|.|.:|||||||:|||.||||||||||||||||||
Human   525 GLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDV 589

  Fly   396 TLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFFIVPPPHRRKPLML 460
            |||||||:||:.||:|:|:|||:.|:|:||||.|.|.||::||::|.::||.|:....:||.
Human   590 TLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKE--- 651

  Fly   461 NTLGVRSAIGSRRKLSFRNVSNVVMQLLHTIKFSEP-----VPFSNIATGSFPSAASALGGGVSV 520
                 ..|:          ::.:..|..::|..:.|     .||.|           .|||.
Human   652 -----EKAM----------IAKMNRQRTNSIGHNPPHWGAERPFYN-----------HLGGN--- 687

  Fly   521 GGGGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYGSVVGSGGGVDSG 585
                                    |||::..|                 ||:
Human   688 ------------------------QVSKEMKR-----------------MGF------------- 698

  Fly   586 ISGGGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRHNHKNNKSQSKVADKFKRPFRKRHSVA 650
                                                  .:.|:..:|...
Human   699 --------------------------------------EDPKDKNAQESA--------------- 710

  Fly   651 AHHQPTNRVNRFLSQAINARSVDCDKSEHVDRLTLRFRQSDMEREYHKDFDLGFTTAMGCSLLLL 715
               .|.:.|:.||.:||:|||:|..:||||.:..|.||:.|:|::|.|..|..|...:.|:.|:.
Human   711 ---NPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVF 772

  Fly   716 ILGAALQVTALPRTLIL--------LLLFLFAFIWVSAILMLLLAVRLKWIIWDISESFSLRMAI 772
            :....:|:|.:|.::.:        |||.|..|:.|....:.|....|:.:...|..|......:
Human   773 LFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLV 837

  Fly   773 TIFTVILIYSVGQVNVFTCVS---------DHPCSGNGTTS-----------------FQNDSHR 811
            .:||:.|::....||:|||.|         :|..|.:...:                 |......
Human   838 GVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWP 902

  Fly   812 KCSLPQYVSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQNIFECYDNRVNAS-- 874
            .|:.|:|.:.|...:.|:.||||::..|.|.:|:|.:..||.|.:|:....:|:..|..|.|:
Human   903 NCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAI 967

  Fly   875 -----------------------------------------IPLHLISLARIAIFMIAILVHGRL 898
                                                     :.|.:::...|::|::|:.:|.:.
Human   968 DFFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQSPEHATKVALKVVTPIIISVFVLALYLHAQQ 1032

  Fly   899 VEGTARLDFLWQLQASQEKKEMDVLQESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVG 963
            ||.||||||||:|||::||:||:.||..|:|:|||:||..|||||| |:.|.|.|||:||...|.
Human  1033 VESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFL-ARERRNDELYYQSCECVA 1096

  Fly   964 VIFASVPNFNEFYTEMDGSDQGLECLRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLI 1028
            |:|||:.||:|||.|::.:::|:|||||||||||||||::.|||||.::||||:||||||..||
Human  1097 VMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGL- 1160

  Fly  1029 PEYKIQPNDP--NSV-RRHMTALIEYVKAMRHSLQEINSHSYNNFMLRVGINIGPVVAGVIGARK 1090
                   ||.  :.| :.|:.||.::...:...::.||.||:|||.:::|:||||||||||||||
Human  1161 -------NDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARK 1218

  Fly  1091 PQYDIWGNTVNVASRMDSTGVPGYSQVTQEVVDSLVGSHFEFRCRGTIKVKGKGDMVTYFL 1151
            ||||||||||||||||||||||...|||.::...|..:.::..|||.:||||||:|:||||
Human  1219 PQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFL 1279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	79/247 (32%)
		CYCc	230..425	CDD:214485	143/195 (73%)
		Guanylate_cyc	266..438	CDD:278633	130/171 (76%)
		DUF1053	624..696	CDD:283888	21/71 (30%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	42/219 (19%)
		CYCc	924..1134	CDD:214485	120/212 (57%)
		Guanylate_cyc	954..1151	CDD:278633	114/199 (57%)
ADCY5	NP_001365188.1	AC_N	1..458	CDD:318454	81/257 (32%)
		Guanylate_cyc	460..633	CDD:306677	131/172 (76%)
		DUF1053	668..760	CDD:399378	37/215 (17%)
		Guanylate_cyc	1087..1281	CDD:306677	116/201 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.710