DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rut and ADCY1

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_066939.1	Gene:	ADCY1 / 107	HGNCID:	232	Length:	1119	Species:	Homo sapiens

Alignment Length:	1238	Identity:	488/1238 - (39%)
Similarity:	692/1238 - (55%)	Gaps:	208/1238 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DHAVKATRGRPLNTL--RFENDELECLYQRYTLKLQRFSVLGVVALVFVLCGVMAALSL--TFNN 62
            :.|...:|.|.|...  .|...|||.|::.|||:|::.:.|..:|::.:|.|.:|...|  ....
Human    22 ERAAGTSRRRGLRACDEEFACPELEALFRGYTLRLEQAATLKALAVLSLLAGALALAELLGAPGP 86

  Fly    63 AATFHNIFNAIVCGLFAVVLVLLQCSVIKDHHLPTLCYGILLFT---ASIC---VVSMPTLGSVF 121
            |.......:.:.|.||..:||:.....::...|..:....|||:   |.:|   .:..|..||..
Human    87 APGLAKGSHPVHCVLFLALLVVTNVRSLQVPQLQQVGQLALLFSLTFALLCCPFALGGPARGSAG 151

  Fly   122 PVDTKEVMAEGVWQIVFVVFLAYAMMPLQIWEAVAFGIALPSVHISLTVYKIFTDALRYLEYNQL 186
            .........:||||::.|.|::||::|::...|:.||:.:.:.|:.:|.  ....|.|...:..|
Human   152 AAGGPATAEQGVWQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTA--TLVPAKRPRLWRTL 214

  Fly   187 IANIVIFIGVNVAGLVVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQM 251
            .||.::|:|||:.|:.|.|:.||:||:.||..|:||..||.::|||||.||||:|:||::|||:|
Human   215 GANALLFVGVNMYGVFVRILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEM 279

  Fly   252 KNDILSPVAGQFHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHC 316
            |.|.|.|....||:||||:|:|||||||||||||.|:|||:|||||:|||||||:||:||.:|||
Human   280 KEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHC 344

  Fly   317 LRIKILGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVL 381
            .|||||||||||||||.:|:.|||.|.|||||||||.|.:|.|||:|.||||||:||||||||||
Human   345 RRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVL 409

  Fly   382 GLRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTF 446
            ||||||:|||||||||||.||:.|.||:||:|:.||..|:|:||||.|:|.||:|:|:.|.::||
Human   410 GLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNSFLKTHNIETF 474

  Fly   447 FIVPPPHRRK--PLMLNTLGVRSAIGSRRKLSFRNVSNVVMQLLHTIK-FSEPVPFSNIATGSFP 508
            ||| |.||||  |.:     :.|.|...:::.|:.|..:::||:|..| |...:||||:
Human   475 FIV-PSHRRKIFPGL-----ILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNV------ 527

  Fly   509 SAASALGGGVSVGGGGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYG 573
                                      .|||         :...|:.:|
Human   528 --------------------------MTCE---------DDDKRRALR----------------- 540

  Fly   574 SVVGSGGGVDSGISGGGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRHNHKNNKSQSKVADK 638
                                                    |||...| :|.:...|
Human   541 ----------------------------------------TASEKLR-NRSSFSTN--------- 555

  Fly   639 FKRPFRKRHSVAAHHQPTNRVNRFLSQAINARSVDCDKSEHVDRLTLRFRQSDMEREYHKDFDLG 703
                       ..:..|..||||::|:.:.||..:.:.:: ::..||:::..:.|::||:..|..
Human   556 -----------VVYTTPGTRVNRYISRLLEARQTELEMAD-LNFFTLKYKHVEREQKYHQLQDEY 608

  Fly   704 FTTAMGCSLLLLILGAALQVTALPRTLILLLLFLFAFIWVSAILMLLLAVRLKWIIWDISESFSL 768
            ||:|:..:|:|..|...:.:...|:::::|||.:|...::.|.::.|...|::.....:  :..:
Human   609 FTSAVVLTLILAALFGLVYLLIFPQSVVVLLLLVFCICFLVACVLYLHITRVQCFPGCL--TIQI 671

  Fly   769 RMAITIFTVILIYSVGQVNVFTCV----SDHP-------CSGNGTTSFQNDSHRKCSLPQYVSLS 822
            |..:.||.|:|||||.|..|..|:    |..|       .||...|:...   ..|....:..|.
Human   672 RTVLCIFIVVLIYSVAQGCVVGCLPWAWSSKPNSSLVVLSSGGQRTALPT---LPCESTHHALLC 733

  Fly   823 AAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQNIFECYDNRVNASI------PLHLIS 881
            .....|.:::|.|:..:.|.:|:.|:.|.|.|.:|||.      |......::      |
Human   734 CLVGTLPLAIFFRVSSLPKMILLSGLTTSYILVLELSG------YTRTGGGAVSGRSYEP----- 787

  Fly   882 LARIAIFMIAILVHGRLVEGTARLDFLWQLQASQEKKEMDVLQESNKRILHNLLPAHVAAHFLDA 946
            :..|.:|..|:.:|.|.|:...|||:||..||.:|:::|:.::..|:|||.||||||||.|||.:
Human   788 IVAILLFSCALALHARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMS 852

  Fly   947 QFRNNMELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGLECLRLLNEIIADFDELLKEDRFRGI 1011
            ..| ||:||:|||::|||:|||:||||:||.|:||::.|:||||||||||||||||:::|.::.|
Human   853 NPR-NMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDI 916

  Fly  1012 DKIKTVGSTYMAVVGLIPEYKIQPNDPNSVRRHMTALIEYVKAMRHSLQEINSHSYNNFMLRVGI 1076
            :||||:||||||.|||.|....:..  .|:..|::.|.::...|...|.|||..|||:|:|||||
Human   917 EKIKTIGSTYMAAVGLAPTSGTKAK--KSISSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGI 979

  Fly  1077 NIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYSQVTQEVVDSLVGSHFEFRCRGTIKVK 1141
            |:|||||||||||:|||||||||||||||||||||.|..|||:||...|....:.|.|||.:.||
Human   980 NVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVCRGKVSVK 1044

  Fly  1142 GKGDMVTYFL--------------------CDSGNKSLNGE---------VRNAMSLPQSLHAPD 1177
            |||:|:||||                    |..|...|.|.         |.....||.  |:|.
Human  1045 GKGEMLTYFLEGRTDGNGSQIRSLGLDRKMCPFGRAGLQGRRPPVCPMPGVSVRAGLPP--HSPG 1107

  Fly  1178 YYM 1180
            .|:
Human  1108 QYL 1110

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	84/245 (34%)
		CYCc	230..425	CDD:214485	143/194 (74%)
		Guanylate_cyc	266..438	CDD:278633	130/171 (76%)
		DUF1053	624..696	CDD:283888	12/71 (17%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	39/167 (23%)
		CYCc	924..1134	CDD:214485	129/209 (62%)
		Guanylate_cyc	954..1151	CDD:278633	122/196 (62%)
ADCY1	NP_066939.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		1/5 (20%)
		AC_N	<161..292	CDD:292831	57/132 (43%)
		CYCc	258..453	CDD:214485	143/194 (74%)
		Guanylate_cyc	294..476	CDD:278633	134/181 (74%)
		Interaction with calmodulin. /evidence=ECO:0000250	493..520		8/26 (31%)
		CYCc	826..1037	CDD:214485	130/213 (61%)
		Guanylate_cyc	859..1056	CDD:278633	124/198 (63%)
		Interaction with calmodulin. /evidence=ECO:0000250	1024..1047		9/22 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	267	1.000	Domainoid score	I1882
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41419
Inparanoid	1	1.050	840	1.000	Inparanoid score	I449
Isobase	1	0.950	-	0	Normalized mean entropy	S11743
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D46761at33208
OrthoFinder	1	1.000	-	-		FOG0006927
OrthoInspector	1	1.000	-	-		oto90906
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	LDO	PTHR45627
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9671
SonicParanoid	1	1.000	-	-		X5020
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.810