DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rut and Adcy3

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_612178.2	Gene:	Adcy3 / 104111	MGIID:	99675	Length:	1145	Species:	Mus musculus

Alignment Length:	1227	Identity:	397/1227 - (32%)
Similarity:	595/1227 - (48%)	Gaps:	252/1227 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LRFENDELECLYQRYTLKLQRFSVLGVVALVFVL---CGVMAALSLTFNNAATFHNIFNAIVCGL 77
            |.|..:.||.|||.| .|.||...| :|.:||..   |.|:...::.|::    ..:...:|.|
Mouse    55 LTFVPESLENLYQTY-FKRQRHETL-LVLVVFAALFDCYVVVMCAVVFSS----DKLAPLMVAG- 112

  Fly    78 FAVVL-----VLLQCSVIKDH----HLPTLCYGILLFTASICVVSMPTLGSVFPVDTKEVMAEGV 133
            |.:||     ||.:..::.|.    .:|.|.:  ||.:|.|    ...||..|  ......::.|
Mouse   113 FGLVLDIILFVLCKKGLLPDRVSRKVVPYLLW--LLISAQI----FSYLGLNF--SRAHAASDTV 169

  Fly   134 -WQIVFVVFLAYAMMPLQIWEAVAFGIALPSVH---ISLTVYKIFTDALRYLE-YNQLIANIVIF 193
             || .|.||..:..:||.:...|...:....||   :.:||.:...|.|..:: ..:::||:.::
Mouse   170 GWQ-AFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQDELEGMQLLREILANVFLY 233

  Fly   194 IGVNVAGLVVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVA----MQMKND 254
            :...:.|::...|.:|..|:.||:.|..:..::.:::::::.|.|:||:||:|||    ..||.|
Mouse   234 LCAIIVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKD 298

  Fly   255 ILSPVAGQFHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRI 319
            .......||:.:|:.:|||||||||||||||.|||.|||||||:||||||.|||:||...|.|||
Mouse   299 ESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRI 363

  Fly   320 KILGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLR 384
            |||||||||:.|||:.|:|||.|::.|||.|::||:.|.|.|...::||||:|||.||.||||.:
Mouse   364 KILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQK 428

  Fly   385 KWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFFIV 449
            :||:||||.|||:||.||:||.|||||::::|:|.|.||::||.|.|..|..||.:.|::|:.|:
Mouse   429 RWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLDEKGIETYLII 493

  Fly   450 PPPHRRKPLMLNTLGVRSAIGSRRKLSFRNVSNVVMQLLHTIKFSEPVPFSNIATGSFPSAASAL 514
                                                                   .|.|......
Mouse   494 -------------------------------------------------------ASKPEVKKTA 503

  Fly   515 GGGVSVGGGGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYGSVVGSG 579
            ..|::        |..|..|:...:...:..:.|               |..|:|..:
Mouse   504 QNGLN--------GSAVPNGAPASSKPSSPALIE---------------TKEPNGSAH------- 538

  Fly   580 GGVDSGISGGGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRHNHKNNKSQSKVADKFKRPFR 644
                         .||..:.....|.....||             :..|.:.:.::.|...|
Mouse   539 -------------ASGSTSEEAEEQEAQADNP-------------SFPNPRRRLRLQDLADR--- 574

  Fly   645 KRHSVAAHHQPTNRVNRFLSQAINAR-SVDCDKSEHVDRLTLRFRQSDMEREYHKDFDLGFTTAM 708
                |....:..:.:|:.|::|:..| |....|..:...||:||...:||..|..:.:.....|.
Mouse   575 ----VVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLTMRFMDPEMETRYSVEKEKQSGAAF 635

  Fly   709 GCSLLLLILGAALQVTALPRTLILLLLFLFAFIWVSAILMLLLAV-------------------- 753
            .||.::|...|.:::...|..:...:.|:     |..:|:|:|.:
Mouse   636 SCSCVVLFCTAMVEILIDPWLMTNYVTFV-----VGEVLLLILTICSMAAIFPRSFPKKLVAFSS 695

  Fly   754 ---RLKWI--IWDISESFSLRMA-ITIFTVILIYSVGQVNVFTCVS-DHPCSGNGTTSFQNDSHR 811
               |.:|.  .|.:...|.|.|| :......|.|.:|..|:...:. |..|..|
Mouse   696 WIDRTRWARNTWAMLAIFILVMANVVDMLSCLQYYMGPYNMTAGMELDGGCMEN----------- 749

  Fly   812 KCSLPQY------VSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQNIFECYDNR 870
                |:|      :||.|....:.||..::|.::   |||.|..|...|:   :...:|:.||::
Mouse   750 ----PKYYNYVAVLSLIATIMLVQVSHMVKLTLM---LLVTGAVTALNLY---AWCPVFDEYDHK 804

  Fly   871 ----------------------VNAS------IPLHLISLARIAIFMIAILVHGRLVEGTARLDF 907
                                  :|.:      :|........:.:.|::.....|.||..||..|
Mouse   805 RFQEKDSPMVALEKMQVLATPGLNGTDSRLPLVPSKYSMTVMMFVMMLSFYYFSRHVEKLARTLF 869

  Fly   908 LWQLQASQEKKEMDVLQESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNF 972
            ||:::...:|:.:..::..|:.::.|:||.|||.|||.::.|:. |||.|||.::||:|||:|||
Mouse   870 LWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDE-ELYSQSYDEIGVMFASLPNF 933

  Fly   973 NEFYTEMDGSDQGLECLRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEYKIQPND 1037
            .:||||...::.|:||||.|||||:|||.||...:||.|.||||:||||||..|:.|:.......
Mouse   934 ADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFT 998

  Fly  1038 PNSVR--------RHMTALIEYVKAMRHSLQEINSHSYNNFMLRVGINIGPVVAGVIGARKPQYD 1094
            .:|..        :|:..|.::..||:.:|..||:.|:||||||:|:|.|.|:|||||||||.||
Mouse   999 SSSKEEKSDKERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYD 1063

  Fly  1095 IWGNTVNVASRMDSTGVPGYSQVTQEVVDSLVGSHFEFRCRGTIKVKGKGDMVTYFL 1151
            ||||||||||||:||||.|..||.:|....|....|.|..||.|.|||||:::|:||
Mouse  1064 IWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFL 1120

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	69/258 (27%)
		CYCc	230..425	CDD:214485	119/198 (60%)
		Guanylate_cyc	266..438	CDD:278633	110/171 (64%)
		DUF1053	624..696	CDD:283888	16/72 (22%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	38/211 (18%)
		CYCc	924..1134	CDD:214485	112/217 (52%)
		Guanylate_cyc	954..1151	CDD:278633	109/204 (53%)
Adcy3	NP_612178.2	AC_N	<44..303	CDD:318454	71/263 (27%)
		Guanylate_cyc	310..494	CDD:306677	115/238 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..564		14/115 (12%)
		Guanylate_cyc	915..1122	CDD:306677	111/206 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710