DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rut and Adcy4

DIOPT Version :9

Sequence 1:NP_511156.2 Gene:rut / 32406 FlyBaseID:FBgn0003301 Length:2248 Species:Drosophila melanogaster
Sequence 2:NP_001348533.1 Gene:Adcy4 / 104110 MGIID:99674 Length:1077 Species:Mus musculus


Alignment Length:1211 Identity:414/1211 - (34%)
Similarity:587/1211 - (48%) Gaps:243/1211 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 ECLYQRYTLKLQRFSVLGVVALVFVLCGVMAALSLTF---NNAATFHNIFNAIVCGL--FAVVLV 83
            :..|:.|....|::.:| ::.||.|||.::|..::.:   ....:..:....::|.|  |:::|.
Mouse    14 DLFYETYYSLSQQYPLL-ILLLVIVLCALVALPAVAWASGRELTSDPSFLTTVLCALGGFSLLLG 77

  Fly    84 LLQCSVIKDHHLP---------------TLCYGILLFTASICVVSMPTLGSVFPVDTKEVMAEGV 133
            |..    ::..|.               .|.|| .|||..  |||.....|.|            
Mouse    78 LAS----REQQLQRWTRPLSGLIWVALLALGYG-FLFTGG--VVSAWDQVSFF------------ 123

  Fly   134 WQIVFVVFLAYAMMPLQIWEAVAFGIALPSVH-ISLTVYKIFTDALRYLEYNQLIANIVIFIGVN 197
               :|::|..|||:||.:.:|.|.|:.....| :.|.:|..:....:.....||.||.|:|:..|
Mouse   124 ---LFIIFTVYAMLPLGMRDAAAAGVISSLSHLLVLGLYLGWQPESQRALLPQLAANAVLFLCGN 185

  Fly   198 VAGLVVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDILSPV-AG 261
            |.|.....:||||.|.||.:..:.:.||..:..|.:..|.||||:||.::|.:||.:|::.: ||
Mouse   186 VVGAYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAG 250

  Fly   262 Q---------FHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCL 317
            |         ||.:|:::|:.||:|:|||||||.|:|:||.:|||.:||||||:|||:|.::.|:
Mouse   251 QRSRPENTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECM 315

  Fly   318 RIKILGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLG 382
            ||||||||||||||||....|||...|.|||||..||..:..||.|.:|||||:|:|.|||||:|
Mouse   316 RIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRVATGVDINMRVGVHSGSVLCGVIG 380

  Fly   383 LRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFF 447
            |:|||:||||:|||||||||:||.|||||:|.|||..|:|.|.||....:.|..|||:.|..|:.
Mouse   381 LQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVERADTEHRDPYLRELGEPTYL 445

  Fly   448 IVPPPHRRKPLMLNTLGVRSAI-GSRRKLSFRNVSNVVMQLLHTIKFSEPVPFSNIATGSFPSAA 511
            ::.|....:.......|:.|:: |...:.|       ::...:...:....||::::....|   
Mouse   446 VIDPRAEEEDEKGTAKGLLSSLEGHTMRPS-------LLMTRYLESWGAAKPFAHLSHLDSP--- 500

  Fly   512 SALGGGVSVGGGGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYGSVV 576
                                            |..|.....|....|..|..:..|.|:      
Mouse   501 --------------------------------VSTSTPLPEKAFSPQWSLDRSRTPRGL------ 527

  Fly   577 GSGGGVDSGISGGGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRHNHKNNKSQSKVADKFKR 641
                  |..:..|                        .|.....|.:.|.:....|||       
Mouse   528 ------DDELDTG------------------------DAKFFQVIEQLNSQKQWKQSK------- 555

  Fly   642 PFRKRHSVAAHHQPTNRVNRFLSQAINARSVDCDKSEHVDRLTLRFRQSDMEREYHKDFDLGFTT 706
                                                 ..:.|||.||:.:||::|.......|..
Mouse   556 -------------------------------------DFNLLTLYFREKEMEKQYRLSALPAFKY 583

  Fly   707 AMGCSLLLLILGAALQ--VTALPRTLIL------LLLFLFAFI------------------WVSA 745
            ...|:.|:.:....:|  ||..|..||:      ||.||..|:                  |:.|
Mouse   584 YAACTFLVFLSNFTIQMLVTTRPPALIITYSITFLLFFLLLFVCFSEHLTKCVQKGPKMLHWLPA 648

  Fly   746 ILMLLLAVRLKWIIWDISESFSLRMAITIFTVILIYSVGQVNVFTCVSDHPC----SGNGTTSFQ 806
             |.:|:|.|.           ..|:|:...|::|::::...::........|    |...:.:|.
Mouse   649 -LSVLVATRP-----------GFRVALGTATILLVFTMAIASLLFLPVSSDCLFLASNVSSVTFN 701

  Fly   807 NDSHRKCSLP---------QYVSLSAAFAFLSVSVFLRLPIIFK-SLLVLGMGTIYGLFIELSHQ 861
            .......|||         .|........|||.|:||.:....| .||:|.:.....||:. ||.
Mouse   702 ASWEMPGSLPLISIPLISIPYSMHCCVLGFLSCSLFLHMSFELKLLLLLLWLVASCSLFLH-SHA 765

  Fly   862 NIFECY---------DNRVNASIPLHLISLARIAIFMIAILVHGRLVEGTARLDFLWQLQASQEK 917
            .:.:|.         |:|........|:......||...:||..|..|...||||||:.:..||:
Mouse   766 WLSDCLIARLYQSPSDSRPGVLKEPKLMGAIYFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQER 830

  Fly   918 KEMDVLQESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYTEMDGS 982
            :|.:.::...:.:|.|:||||||..|: .|.|.|.:||||||..|.|:|||||:|.|||:|.:.:
Mouse   831 EETETMENLTRLLLENVLPAHVAPQFI-GQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNIN 894

  Fly   983 DQGLECLRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEYKIQPNDPNSVR--RHM 1045
            .:|||||||||||||||||||.:.:|.|::||||:||||||..|| .....|....:|.|  .|:
Mouse   895 HEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGL-NATSGQDTQQDSERSCSHL 958

  Fly  1046 TALIEYVKAMRHSLQEINSHSYNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTG 1110
            ..::|:..|:...|..||.||:|||.||||:|.||||||||||:|||||||||||||||||:|||
Mouse   959 GTMVEFAVALGSKLGVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTG 1023

  Fly  1111 VPGYSQVTQEVVDSLVGSHFEFRCRGTIKVKGKGDMVTYFL 1151
            |.|..|||:|...:|....:....||:|||||||::.||||
Mouse  1024 VLGKIQVTEETARALQSLGYTCYSRGSIKVKGKGELCTYFL 1064

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rutNP_511156.2 AC_N <17..255 CDD:292831 69/251 (27%)
CYCc 230..425 CDD:214485 120/204 (59%)
Guanylate_cyc 266..438 CDD:278633 107/171 (63%)
DUF1053 624..696 CDD:283888 11/71 (15%)
SLC5-6-like_sbd <742..>893 CDD:294310 37/173 (21%)
CYCc 924..1134 CDD:214485 119/211 (56%)
Guanylate_cyc 954..1151 CDD:278633 118/198 (60%)
Adcy4NP_001348533.1 AC_N <115..246 CDD:318454 46/145 (32%)
Guanylate_cyc 264..418 CDD:306677 101/153 (66%)
DUF1053 479..580 CDD:368844 26/215 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 502..524 4/21 (19%)
Guanylate_cyc 866..1065 CDD:306677 120/200 (60%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100296
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.710

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