DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rut and gucy1a2

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	XP_009290254.2	Gene:	gucy1a2 / 100330875	ZFINID:	ZDB-GENE-121023-3	Length:	608	Species:	Danio rerio

Alignment Length:	438	Identity:	107/438 - (24%)
Similarity:	185/438 - (42%)	Gaps:	112/438 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 SLTFNNAATFHNIFNAIVCGLFAVVLVLLQCSVIKDHHLPTLCYGILLFTASICVVSMPTLGSVF 121
            :|||:|:              |.:|...:.||.          ..|||..::...:.....||
Zfish   232 TLTFSNS--------------FELVSPRIPCSF----------QNILLRLSTPFTIRTRPDGS-- 270

  Fly   122 PVDTKEVMAEGVWQIVF------VVFLAYAMMPLQIWEAVAFGIALPSVHISLTVYKIFTDALRY 180
            .:|.:|.:.|...|::.      ::||....:. ::.|.:..|:.|..:.|.        ||.|
Zfish   271 SLDCREKVMELKGQMLHLPESNSIMFLGSPRVD-RLEELMGRGLHLSDIPIH--------DATR- 325

  Fly   181 LEYNQLIANIVIFIGVNVAGLVVNIMMERAQRRTFLDTR-NCIASRLE-----IQDENEKLERLL 239
                     .||.:|            |:|:.:..|..| :.:.:.||     :::|..:...||
Zfish   326 ---------DVILVG------------EQAKAQDGLKKRMDKLKATLEKTHQALEEEKRRTVDLL 369

  Fly   240 LSVLPQHVAMQMKNDILSPVAGQFHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELF 304
            .|:.|..||.::...:  ||..       :|.::|::||:||||||.:.:||:..:::.:||||:
Zfish   370 YSIFPGDVAQRLWQGL--PVQA-------KKFDDVTMLFSDIVGFTAVCAQCTPMQVISMLNELY 425

  Fly   305 GRFDQLAHDNHCLRIKILGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRV 369
            .|||.........:|:.:||.|....||......|||....|.|.|::....|:......:.:|:
Zfish   426 TRFDYQCGILDVYKIETIGDAYCVAGGLHRKIDSHAKPIALMALKMMELSEEVLTPDGKPIKLRI 490

  Fly   370 GIHTGRVLCGVLGLRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDSLSGE----------- 423
            |||:|.||.||:|:...::.::.|:||||:..|||..|..::|:..|...|..:
Zfish   491 GIHSGSVLAGVVGVMMPRYCLFGNNVTLASKFESGSHPRCINVSPTTYQLLRDDRSFTFIPRSRQ 555

  Fly   424 --------------YEVEAGHGDE-------RSSYLR--DHGVDTFFI 448
                          |.:|||....       ||:.:|  .:.:.|.|:
Zfish   556 ELPDNFPKEIPGICYFLEAGKSQSHASLTSTRSAPIRKVSYNIGTMFL 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	42/209 (20%)
		CYCc	230..425	CDD:214485	63/219 (29%)
		Guanylate_cyc	266..438	CDD:278633	60/203 (30%)
		DUF1053	624..696	CDD:283888
		SLC5-6-like_sbd	<742..>893	CDD:294310
		CYCc	924..1134	CDD:214485
		Guanylate_cyc	954..1151	CDD:278633
gucy1a2	XP_009290254.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810