Protein Alignment rut and adcy8

DIOPT Version :9

• Sequence 1: NP_511156.2
• Gene: rut / 32406
• FlyBaseID: FBgn0003301
• Length: 2248
• Species: Drosophila melanogaster
• Sequence 2: NP_001137224.1
• Gene: adcy8 / 100148976
• ZFINID: ZDB-GENE-070912-197
• Length: 1225
• Species: Danio rerio
• Alignment Length: 1255
• Identity: 457/1255 - (36%)
• Similarity: 665/1255 - (52%)
• Gaps: 240/1255 - (19%)

  Fly     9 RGRPLNTLR--FENDELECLYQRYTLKLQRFSVLGVVALVFVLCGVMAALSLTFNNAATFHNIFN 71
            ||....|||  |::.:||.|||||.|..:|.||:.:..|..|....:..|.||.  |:|..:...
Zfish   124 RGVIFPTLRYAFKSRDLERLYQRYFLGQRRKSVVVMNILDVVTKLTLLVLHLTL--ASTPMDPIK 186

  Fly    72 AIVCGLFAVVLVLLQCSVI---KDHHLPTLCYGILLFTASICVVSMPT------LGSVFPVDTKE 127
            .::.|.|..:.|:: |:::   ||    |..:|.|.::.::..|:|.|      ||       ..
Zfish   187 GMLLGFFTGIEVVI-CALVVVRKD----TSSHGYLQYSGAVTWVAMATQILATGLG-------YG 239

  Fly   128 VMAEGVWQIVFVVFLAYAMMPLQIWEAVAFGIALPSVHISLTVYKIFTDALRYLEYNQLIANIVI 192
            ::.:|:..::|.:|..|:|:||.:..|:..|:...::||:|   ::.......:..|||:|.:::
Zfish   240 LLGDGIGYVLFTLFATYSMLPLPLTWAIVAGLLTSALHIAL---QLLVPPRAQISTNQLLAQVLL 301

  Fly   193 FIGVNVAGLVVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDILS 257
            |:.:|.||:.::.:.:||||:.||:||.||.:||.::.||::.|||:|||||:.|.::|.||:.:
Zfish   302 FLCINTAGMFISYLSDRAQRQAFLETRRCIEARLRLETENQRQERLVLSVLPRFVVLEMINDMTN 366

  Fly   258 ----PVAGQFHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLR 318
                .:..|||||||.::|||||||||:.|||.||:..|||||||:|||||.|||:|||::||||
Zfish   367 VEDETLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLR 431

  Fly   319 IKILGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGL 383
            ||||||||||||||||||.|||.|.|||||.||..|..|...|...::||:|||:|.||||||||
Zfish   432 IKILGDCYYCVSGLPEPRPDHAHCCVEMGLSMIKTIRYVRSRTKHDIDMRIGIHSGSVLCGVLGL 496

  Fly   384 RKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFFI 448
            |||||||||.||.:||.:||||.|||:|:::|.||.|:|:||||.|||.:|:.:||.|.::||.|
Zfish   497 RKWQFDVWSWDVDIANKLESGGIPGRIHISKAALDCLNGDYEVEEGHGKDRNDFLRRHNIETFLI 561

  Fly   449 VPPPHRRKPLMLNTLGVRSAIGSRRKLSFRNVSNVVMQLLHTIKFSE-----PVPFSNIATGSFP 508
            ..|......|..:.:              |:.:|..........|:|     .:||.||
Zfish   562 KQPEESLLTLPEDIM--------------RDSTNQSDHRTSNTSFTEGTWSPELPFHNI------ 606

  Fly   509 SAASALGGGVSVGGGGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYG 573
                                  |.:.:|..|.:.:
Zfish   607 ----------------------VGKQNTLAALTRH------------------------------ 619

  Fly   574 SVVGSGGGVDSGISGGGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRHNHKNNKSQSKVADK 638
                                            ::...||..|..:       |....||
Zfish   620 --------------------------------SINLLPNHLAQAL-------HVRAGSQ------ 639

  Fly   639 FKRPFRKRHSVAAHHQPTNRVNRFLSQAINARSVDCDKSEHVDRLTLRFRQSDMEREYHKDFDLG 703
                               .:|..:...|..||.|..:.||:...:|.||::.:|.:|.:..|..
Zfish   640 -------------------EINARMQSTIALRSGDKLRQEHISPFSLTFREALLEHKYSQMRDEV 685

  Fly   704 FTTAMGCSLLLL--------ILGAALQVTALPRTLILLLLFLFAFIWVSA----ILMLLLAVRLK 756
            |.:.:.|:.::|        :|.:|..||.|.:..:|:||.....:..:|    .|.|:|.....
Zfish   686 FKSNLVCAFIVLFFITGIQSLLPSARMVTMLIQFSVLILLHCCLVVVTTAEDYKCLPLVLRKACC 750

  Fly   757 WIIWDISESFSLRMAITIFTVILIYSVGQVNVFTCVSDHPCSGNGTTSFQNDSHRK-------CS 814
            |    ::|:::.|..:...::::.:....:|:..|  |...||    ||:|.:...       |.
Zfish   751 W----VNETYAARNVVIFLSILINFLAAMINILWC--DFDKSG----SFRNQTFNASASIPDICF 805

  Fly   815 LPQYVSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQNIFECYD----NRVNASI 875
            .|:|...:...|.::.:|||||..:.|..::|.|..||.:..|..:..:|..||    |:..:.:
Zfish   806 YPEYFVFTGVLAMVTCAVFLRLNSVLKLAILLIMIAIYAVLTEAFYTPLFIRYDTLTLNQSKSFL 870

  Fly   876 PLHLISLARIAIFMIAILVHGRLVEGTARLDFLWQLQASQEKKEMDVLQESNKRILHNLLPAHVA 940
            .....||..:|:|::|:..||:.:|.||||||||::||.:|..||..|:|.|:.:|.|:||:|||
Zfish   871 GTKETSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMRELREHNENMLRNILPSHVA 935

  Fly   941 AHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGLECLRLLNEIIADFDELLKE 1005
            .|||:.. |:|.|||.|||..|||:|||:|.|.:||::.:.::||:|||||||||||||||||.|
Zfish   936 RHFLEKD-RDNEELYSQSYDTVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGE 999

  Fly  1006 DRFRGIDKIKTVGSTYMAVVGLIPEYKIQPNDPNSVRRHMTALIEYVKAMRHSLQEINSHSYNNF 1070
            :||:.|:||||:|||||||.||.|| |.|..|...   |:.||.::..|:..|:||||.||:|||
Zfish  1000 ERFQDIEKIKTIGSTYMAVSGLSPE-KQQCEDKWG---HLCALADFAIALNESIQEINKHSFNNF 1060

  Fly  1071 MLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYSQVTQEVVDSLVGSHFEFRCR 1135
            .||:|:..|.||||||||:||||||||.|||:|||||||||.|..|:.:|....|....|.|..|
Zfish  1061 QLRIGMAHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGKIQLPEETYAILNERGFAFEYR 1125

  Fly  1136 GTIKVKG----KGDMVTYFLCD--------------SGNKSLNGEVRNAMSLPQSLHAPDYYMKV 1182
            |.|.|||    :|.:.|:|:..              :|..||...|   :.|.|||:
Zfish  1126 GEIYVKGISEQEGKIRTHFMIGRVQPNPLILQPRKLTGQYSLAAVV---LGLVQSLN-------- 1179

  Fly  1183 SQFPENRVNTDTYSKKENGH 1202
            .|..:..:|.:..|....||
Zfish  1180 RQKQKQILNENNNSGIMKGH 1199

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	79/248 (32%)
		CYCc	230..425	CDD:214485	129/198 (65%)
		Guanylate_cyc	266..438	CDD:278633	119/171 (70%)
		DUF1053	624..696	CDD:283888	14/71 (20%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	39/165 (24%)
		CYCc	924..1134	CDD:214485	123/209 (59%)
		Guanylate_cyc	954..1151	CDD:278633	116/200 (58%)
adcy8	NP_001137224.1	AC_N	<135..374	CDD:292831	79/255 (31%)
		CYCc	340..538	CDD:214485	129/197 (65%)
		Guanylate_cyc	379..563	CDD:278633	125/183 (68%)
		DUF1053	592..685	CDD:283888	28/214 (13%)
		CYCc	919..1123	CDD:214485	122/208 (59%)
		Guanylate_cyc	948..1147	CDD:278633	117/202 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810