DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rut and gucy1a2

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_001120379.1	Gene:	gucy1a2 / 100145454	XenbaseID:	XB-GENE-1011801	Length:	712	Species:	Xenopus tropicalis

Alignment Length:	399	Identity:	106/399 - (26%)
Similarity:	179/399 - (44%)	Gaps:	85/399 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 TFNNAATFHNIF--NAIVCGLFAVVLVLLQCSVIKDHHLPTLCYGILLFTASICVVSMPTLGSVF 121
            ||..|..||.:|  |.::..|...:..|::|.|.|          .:.|..|..:|| |.:...|
Frog   302 TFCRAFPFHLMFDPNMLILQLGEGLRKLIKCEVHK----------TMQFHDSFEIVS-PKISCTF 355

  Fly   122 --------------------PVDTKEVMAEGVWQIVFV------VFLAYAMMPLQIWEAVAFGIA 160
                                ..:.|:.:.|...|:::|      :||....:. ::.|.:..|:.
Frog   356 EQVLLRLSTPFVIRNKPDAPTFENKDKVMEVKGQMIYVPESSSILFLGSPRVD-KLDELMGRGLH 419

  Fly   161 LPSVHISLTVYKIFTDALRYLEYNQLIANIVIFIGVNVAGLVVNIMMERAQRRTFLDTR-NCIAS 224
            |..:.|.        ||.|          .||.:|            |:|:.:..|..| :.:.:
Frog   420 LSDIPIH--------DATR----------DVILVG------------EQAKAQDGLKKRMDKLKA 454

  Fly   225 RLE-----IQDENEKLERLLLSVLPQHVAMQMKNDILSPVAGQFHRIYIQKHENVSILFADIVGF 284
            .||     :::|.:|...||.|:.|..||.|:         .:...:..:|.::|::||:|||||
Frog   455 TLEKTHQALEEEKKKTVDLLYSIFPGDVAQQL---------WEGKSVQARKFDDVTMLFSDIVGF 510

  Fly   285 TVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYYCVSGLPEPRKDHAKCAVEMGLD 349
            |.:.:||:..:::.:||||:.|||.........:::.:||.|...:||......|||....|.|.
Frog   511 TAVCAQCTPMQVISMLNELYTRFDYQCGFLDIYKVETIGDAYCVAAGLLRQSNSHAKPIALMALK 575

  Fly   350 MIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDVTLANHMESGGEPGRVHVTR 414
            |::....|:......:.||:|||:|.||.||:|:|..::.::.|:||||:..|||..|.|::|:.
Frog   576 MMELSEEVLTPDGRPIKMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSP 640

  Fly   415 ATLDSLSGE 423
            .|...|..|
Frog   641 TTYQLLKDE 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	49/229 (21%)
		CYCc	230..425	CDD:214485	66/194 (34%)
		Guanylate_cyc	266..438	CDD:278633	57/158 (36%)
		DUF1053	624..696	CDD:283888
		SLC5-6-like_sbd	<742..>893	CDD:294310
		CYCc	924..1134	CDD:214485
		Guanylate_cyc	954..1151	CDD:278633
gucy1a2	NP_001120379.1	Pap_E4	30..>86	CDD:367150
		HNOB	<132..248	CDD:377902
		HNOBA	296..486	CDD:369471	48/225 (21%)
		Guanylate_cyc	492..679	CDD:306677	57/158 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910