DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rut and adcy7

DIOPT Version :9

Sequence 1:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster
Sequence 2:	NP_001106549.1	Gene:	adcy7 / 100127741	XenbaseID:	XB-GENE-1005225	Length:	1061	Species:	Xenopus tropicalis

Alignment Length:	1211	Identity:	425/1211 - (35%)
Similarity:	614/1211 - (50%)	Gaps:	233/1211 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 FENDELE-----CLYQRYTLKLQRFSVLGVVALVFVL---CGVMAALSLTFNNAATFH-----NI 69
            |.||..:     .||::|....|.:.:|  :.|:||:   |..:..|..||:.....|     .:
Frog     8 FINDNEDWMISPSLYEKYQCISQHYPLL--LILLFVVGASCVTLIVLFFTFSQEPFRHLAFIITV 70

  Fly    70 FNAIV--CGLFAVVLVLLQCSVIKDHHLPTLCYGILLFTASICVVSMPTLGSVFPVDTKEVMAEG 132
            |.|:|  |.|:  :||..:..|.|...:    :.::::   ||::   |:|.|...|:..|.|
Frog    71 FVALVVFCALY--ILVYTESFVQKWLRV----FSLVIY---ICLL---TIGYVLTYDSSVVHA-- 121

  Fly   133 VWQ----IVFVVFLAYAMMPLQIWEAVAFGIALPSVH---ISLTVY--KIFTDALRYLEYNQLIA 188
             |.    .:|:.|..|.|:||.:...:...|.....|   ||:||.  ....||:.:    ||:|
Frog   122 -WDQVPFFLFITFSVYTMLPLGMQACLIVSIISGISHIIVISITVVLSSGSNDAIAF----QLMA 181

  Fly   189 NIVIFIGVNVAGLVVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMK- 252
            |.|||:..|:.|......|:.|.|..:..|..||..:::::.:..:.|.|||||||.:::|:||
Frog   182 NAVIFLCGNLMGAYHKYHMQDASRDLYSYTVKCIRIKMKLELKKRQQESLLLSVLPVYISMEMKL 246

  Fly   253 ---------NDILSPVAGQFHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFD 308
                     ||...| ...||.:|:::|:|||||:|||||||.|:|.||.:|||.:||||||:||
Frog   247 AIQDRLTETNDNRQP-DNNFHSLYVKRHQNVSILYADIVGFTRLASDCSPKELVVMLNELFGKFD 310

  Fly   309 QLAHDNHCLRIKILGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHT 373
            |:|.:|.|:||||||||||||||||....::||..|:||||:.:||..|.|||...:|||||:|:
Frog   311 QIAKENECMRIKILGDCYYCVSGLPVSLPNNAKNCVKMGLDICEAIKQVREATGADINMRVGVHS 375

  Fly   374 GRVLCGVLGLRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYL 438
            |.|||||:|||||||||||:||:|||.|||.|.|||||:|.|||..::|.|:||.|||:.|..||
Frog   376 GNVLCGVIGLRKWQFDVWSHDVSLANRMESAGLPGRVHITEATLKHMNGAYDVEEGHGELRDPYL 440

  Fly   439 RDHGVDTFFIVPPPHRRKPLMLNTL---------GVRSAIGSRRKLSFRNVSNVVMQLLHTIKFS 494
            ::..:.||.::.|..:...:..|.|         .||.::...|.|.               .:.
Frog   441 KEMNIKTFLVIDPRAKNSRVKNNHLTRHRVNDGIKVRPSVRMTRYLE---------------SWG 490

  Fly   495 EPVPFSNIATGSFPSAASALGGGVSVGGGGGGGGGGVARGSTCEANSGNV-QVSEKGSRKVIRLQ 558
            ...|||:.                                ...:|:|..| .|:.|...::
Frog   491 AARPFSHF--------------------------------DQTDASSTEVPTVNGKPKPEI---- 519

  Fly   559 KILHATPPPHGMGYGSVVGSGGGVDSGISGGGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHR 623
                   |..|||.                                 ||.|..|.
Frog   520 -------PLKGMGR---------------------------------TVKTERNV---------- 534

  Fly   624 HNHKNNKSQSKVADKFKRPFRKRHSVAAHHQPTNRVNRFLSQAINARSVDCDKSEHVDRLTLRFR 688
             :.|.|:.:.                 .|.:..|.::     .:::......|::......|.|.
Frog   535 -SQKRNQEEE-----------------LHDRMMNTID-----GLSSAKPWFGKTDDFYGFLLFFT 576

  Fly   689 QSDMEREYHKDFDLG-FTTAMGCSLLLLILGAALQVTALPRTLILLLLF---LFAFIWVSAILML 749
            ...:|:|| :.|.:. ..:...|:.|:.:....:|:..:||:..|.:.|   ....:||..|..:
Frog   577 ADGLEKEY-RTFRIPCIQSYFLCASLIFLCIFLIQILVMPRSANLGISFGVVSVLILWVLLICYV 640

  Fly   750 LLAVR-----------LKWIIWDISESFSLRMAITIFTV--ILIYSVGQVNVFTCVSDHPCSGNG 801
            ....|           |..::..|....|||:.:...|:  :||.|:  ||:....:...|:
Frog   641 DKCARFCNENAPFSRFLCSLVEMIETRPSLRVPLVALTLGSLLIISI--VNLPLDQTLQTCN--- 700

  Fly   802 TTSFQNDSHRKC-SLPQYVSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQNIFE 865
            |:|...:|  :| |:|.|| .......::.|:|||:....|.||:....|.|.:.|..:|.:||.
Frog   701 TSSIATES--QCQSIPYYV-YCCILGLVACSMFLRMCFELKILLLTAAFTAYNVIIFHTHSSIFR 762

  Fly   866 CYDNRVNASI----PLHLISLARIAIFMIAILVHGRLVEGTARLDFLWQLQASQEKKEMDVLQES 926
               :.:|:||    ....:|...::::.:.:::..|.||..:|||.||:.:..:|.:|::.::..
Frog   763 ---SNLNSSIGVLEDFQKMSCFYLSLYYLTLVLLARQVEYYSRLDCLWKRKFRKEDEEIETMENL 824

  Fly   927 NKRILHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGLECLRL 991
            |:.:|.|:|||||||:|:|.. |:|.:||||||..|.|:|||||.|..||||.|.:.:|||||||
Frog   825 NQLLLENVLPAHVAAYFIDDN-RSNEDLYHQSYDCVCVMFASVPEFKVFYTECDVNKEGLECLRL 888

  Fly   992 LNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEYKIQPNDPNSVRRHMTALI----EYV 1052
            ||||||||||||.:.:|.|::||||:||||||..||    ...|...|..:....|||    ||.
Frog   889 LNEIIADFDELLMKPKFSGVEKIKTIGSTYMAATGL----TATPGQENQDQEKQHALIGITVEYA 949

  Fly  1053 KAMRHSLQEINSHSYNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYSQV 1117
            .|:...|..||.||:|||.||||||.|||:||||||:|||||||||||||||||:|||..|..||
Frog   950 MALMSKLDGINRHSFNNFRLRVGINHGPVIAGVIGAKKPQYDIWGNTVNVASRMESTGELGKIQV 1014

  Fly  1118 TQEVVDSLVGSHFEFRCRGTIKVKGKGDMVTYFLCDSGNKS 1158
            |:|....|.|..:...|||.|.|||||::.|||:|....||
Frog  1015 TEETCQILEGLGYSCECRGFINVKGKGELRTYFVCTDMAKS 1055

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rut	NP_511156.2	AC_N	<17..255	CDD:292831	75/270 (28%)
		CYCc	230..425	CDD:214485	120/204 (59%)
		Guanylate_cyc	266..438	CDD:278633	111/171 (65%)
		DUF1053	624..696	CDD:283888	8/71 (11%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	41/168 (24%)
		CYCc	924..1134	CDD:214485	124/213 (58%)
		Guanylate_cyc	954..1151	CDD:278633	121/200 (61%)
adcy7	NP_001106549.1	AC_N	<21..266	CDD:318454	74/266 (28%)
		Guanylate_cyc	268..418	CDD:306677	100/149 (67%)
		DUF1053	483..591	CDD:399378	29/232 (13%)
		Guanylate_cyc	851..1048	CDD:306677	121/200 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910